Assessment of drug permeability through an ex vivo porcine round window membrane model.
Drug delivery system
Health technology
Membranes
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
16 Jun 2023
16 Jun 2023
Historique:
received:
26
09
2022
revised:
16
03
2023
accepted:
26
04
2023
medline:
22
5
2023
pubmed:
22
5
2023
entrez:
22
5
2023
Statut:
epublish
Résumé
Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is challenging. Systemic delivery is not effective as only a small fraction of the therapeutic agent reaches the inner ear. Invasive surgeries to inject through the round window membrane (RWM) or cochleostomy may cause damage to the inner ear. An alternative approach is to administer drugs into the middle ear using an intratympanic injection, with the drugs primarily passing through the RWM to the inner ear. However, the RWM is a barrier, only permeable to a small number of molecules. To study and enhance the RWM permeability, we developed an
Identifiants
pubmed: 37213232
doi: 10.1016/j.isci.2023.106789
pii: S2589-0042(23)00866-0
pmc: PMC10197016
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106789Subventions
Organisme : NIDCD NIH HHS
ID : R21 DC020005
Pays : United States
Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests. The authors have assigned rights to a pending patent application to North Carolina State University.
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