COVID-19 Outcomes in Patients with Cancer Receiving Immune Checkpoint Inhibitors: A Systematic Review.

COVID-19 SARS-CoV-2 immune checkpoint inhibitors immune-related adverse events immunotherapy

Journal

Journal of immunotherapy and precision oncology
ISSN: 2590-017X
Titre abrégé: J Immunother Precis Oncol
Pays: United States
ID NLM: 101768397

Informations de publication

Date de publication:
May 2023
Historique:
received: 25 08 2022
revised: 16 12 2022
accepted: 21 12 2022
medline: 22 5 2023
pubmed: 22 5 2023
entrez: 22 5 2023
Statut: epublish

Résumé

Immune checkpoint inhibitors (ICIs) can cause inflammatory and immune-related adverse events (irAEs) that might worsen the course of COVID-19. We conducted a systematic review (PROSPERO ID: CRD42022307545) to evaluate the clinical course and complications of COVID-19 in patients with cancer receiving ICI. We searched Medline and Embase through January 5, 2022. We included studies evaluating patients with cancer who received ICI and developed COVID-19. Outcomes included mortality, severe COVID-19, intensive care unit (ICU) and hospital admissions, irAEs, and serious adverse events. We pooled data with random effects meta-analysis. Twenty-five studies met study eligibility ( Although current evidence is limited, COVID-19 clinical outcomes of patients with cancer receiving ICI therapy appear to be similar to those not receiving oncologic treatment or other cancer therapies.

Identifiants

pubmed: 37214207
doi: 10.36401/JIPO-22-24
pmc: PMC10195019
doi:

Types de publication

Journal Article

Langues

eng

Pagination

103-110

Subventions

Organisme : NCI NIH HHS
ID : K08 CA237619
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States

Déclaration de conflit d'intérêts

Conflict of interest: Dr. Suarez-Almazor has received consultant fees in the past 12 months from Pfizer, Eli Lilly, and Bristol Myers Squibb/Celgene, unrelated to this study.

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Auteurs

Juan I Ruiz (JI)

Health Services Research Department, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.

Maria A Lopez-Olivo (MA)

Health Services Research Department, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.

Yimin Geng (Y)

Research Medical Library, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.

Maria E Suarez-Almazor (ME)

Health Services Research Department, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.

Classifications MeSH