Surface modification strategies and the functional mechanisms of gold nanozyme in biosensing and bioassay.

Biosensing and bioassay Catalytic activity Gold nanozyme Surface modification

Journal

Materials today. Bio
ISSN: 2590-0064
Titre abrégé: Mater Today Bio
Pays: England
ID NLM: 101757228

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 06 02 2023
revised: 19 04 2023
accepted: 03 05 2023
medline: 22 5 2023
pubmed: 22 5 2023
entrez: 22 5 2023
Statut: epublish

Résumé

Gold nanozymes (GNZs) have been widely used in biosensing and bioassay due to their interesting catalytic activities that enable the substitution of natural enzyme. This review explains different catalytic activities of GNZs that can be achieved by applying different modifications to their surface. The role of Gold nanoparticles (GNPs) in mimicking oxidoreductase, helicase, phosphatase were introduced. Moreover, the effect of surface properties and modifications on each catalytic activity was thoroughly discussed. The application of GNZs in biosensing and bioassay was classified in five categories based on the combination of the enzyme like activities and enhancing/inhibition of the catalytic activities in presence of the target analyte/s that is realized by proper surface modification engineering. These categories include catalytic activity enhancer, reversible catalytic activity inhibitor, binding selectivity enhancer, agglomeration base, and multienzyme like activity, which are explained and exemplified in this review. It also gives examples of those modifications that enable the application of GNZs for

Identifiants

pubmed: 37214551
doi: 10.1016/j.mtbio.2023.100656
pii: S2590-0064(23)00116-3
pmc: PMC10199192
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

100656

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Sanam Garehbaghi (S)

Central European Institute of Technology, Brno University of Technology, Purkynova 123, Brno, CZ-612 00, Czech Republic.

Amir M Ashrafi (AM)

Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, Brno, CZ-613 00, Czech Republic.

Vojtěch Adam (V)

Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, Brno, CZ-613 00, Czech Republic.

Lukáš Richtera (L)

Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, Brno, CZ-613 00, Czech Republic.

Classifications MeSH