Prevalence of Bacterial Urinary Tract Infection, Associated Risk Factors, and Antimicrobial Resistance Pattern in Addis Ababa, Ethiopia: A Cross-Sectional Study.
antimicrobial resistance pattern
prevalence
urinary tract infection
uropathogen
Journal
Infection and drug resistance
ISSN: 1178-6973
Titre abrégé: Infect Drug Resist
Pays: New Zealand
ID NLM: 101550216
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
12
2022
accepted:
09
05
2023
medline:
22
5
2023
pubmed:
22
5
2023
entrez:
22
5
2023
Statut:
epublish
Résumé
Urinary tract infections (UTIs) brought a significant and serious health-related problem that may lead to the subsequent development of serious indications with the challenge of the emergence of antibiotic resistance. Therefore, the choice of antibiotics depends on the accuracy of the diagnostic tool of UTIs to minimize false results that may subject patients to wrong treatments. This study aimed to determine the prevalence of bacteriuria, associated factors, and AMR pattern of UTI-suspected patients. A cross-sectional study was conducted from March to May 2022, at Arsho Advanced Medical Laboratory (AAML), Addis Ababa, Ethiopia. Species identification and isolation from bacterial colonies were characterized by gram stain and biochemical properties followed by antibiotic susceptibility testing using the Kirby-Bauer method on Muller-Hinton agar. Logistic regression analysis was carried out to determine the association between the independent variables and significant bacterial growth to identify factors that affect the prevalence of UTI. A test is considered statistically significant that has a P value less than 0.05. Out of 141 (31.6%) which yielded significant bacteriuria, 16 different species of bacterial uropathogens were identified. A total of 105/446 (91 Gram-negative and 14 Gram-positive) of bacterial growth in the female gender and 36/446 (33 Gram-negative and 3 Gram positive) in male were observed with a P value of 0.03. The most predominant bacteria were Based on our study finding, the ordinarily used antibiotics seem to face emerging resistant strains, which needs considerable and due attention to the impact of UTI in developing countries including Ethiopia. History of previous UTIs and female gender were shown to be possible risk factors associated with UTIs.
Sections du résumé
Background
UNASSIGNED
Urinary tract infections (UTIs) brought a significant and serious health-related problem that may lead to the subsequent development of serious indications with the challenge of the emergence of antibiotic resistance. Therefore, the choice of antibiotics depends on the accuracy of the diagnostic tool of UTIs to minimize false results that may subject patients to wrong treatments. This study aimed to determine the prevalence of bacteriuria, associated factors, and AMR pattern of UTI-suspected patients.
Methods
UNASSIGNED
A cross-sectional study was conducted from March to May 2022, at Arsho Advanced Medical Laboratory (AAML), Addis Ababa, Ethiopia. Species identification and isolation from bacterial colonies were characterized by gram stain and biochemical properties followed by antibiotic susceptibility testing using the Kirby-Bauer method on Muller-Hinton agar. Logistic regression analysis was carried out to determine the association between the independent variables and significant bacterial growth to identify factors that affect the prevalence of UTI. A test is considered statistically significant that has a P value less than 0.05.
Results
UNASSIGNED
Out of 141 (31.6%) which yielded significant bacteriuria, 16 different species of bacterial uropathogens were identified. A total of 105/446 (91 Gram-negative and 14 Gram-positive) of bacterial growth in the female gender and 36/446 (33 Gram-negative and 3 Gram positive) in male were observed with a P value of 0.03. The most predominant bacteria were
Conclusion
UNASSIGNED
Based on our study finding, the ordinarily used antibiotics seem to face emerging resistant strains, which needs considerable and due attention to the impact of UTI in developing countries including Ethiopia. History of previous UTIs and female gender were shown to be possible risk factors associated with UTIs.
Identifiants
pubmed: 37215305
doi: 10.2147/IDR.S402279
pii: 402279
pmc: PMC10199700
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3041-3050Informations de copyright
© 2023 Gebretensaie et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Asian Pac J Trop Med. 2016 Aug;9(8):771-6
pubmed: 27569886
Int J Microbiol. 2018 Oct 02;2018:8492309
pubmed: 30386381
Clin Microbiol Rev. 1988 Jul;1(3):268-80
pubmed: 3058296
Curr Drug Targets. 2012 Oct;13(11):1386-99
pubmed: 22664092
N Am J Med Sci. 2012 Apr;4(4):163-9
pubmed: 22536558
Urologia. 2014 Oct-Dec;81(4):222-7
pubmed: 25451882
J Family Med Prim Care. 2015 Apr-Jun;4(2):265-8
pubmed: 25949979
Int J Microbiol. 2019 Feb 17;2019:4246780
pubmed: 30906323
Clin Infect Dis. 1993 Jun;16(6):785-91
pubmed: 7687152
Am Fam Physician. 2020 Sep 1;102(5):278-285
pubmed: 32866365
Int J Microbiol. 2020 Jul 28;2020:8896990
pubmed: 32774382
J Pediatr. 2020 Feb;217:110-117.e4
pubmed: 31787323
BMC Pregnancy Childbirth. 2021 Feb 23;21(1):159
pubmed: 33622283
Infect Dis Clin North Am. 2014 Mar;28(1):1-13
pubmed: 24484571
J Bras Nefrol. 2013 Apr-Jun;35(2):93-8
pubmed: 23812565
Ann Clin Microbiol Antimicrob. 2007 Mar 23;6:4
pubmed: 17378940
Int J Antimicrob Agents. 2018 Dec;52(6):771-782
pubmed: 30312654
BMC Infect Dis. 2018 Jan 10;18(1):30
pubmed: 29320984