A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment.
Biological sciences
Medicine
Molecular neuroscience
Neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
19 May 2023
19 May 2023
Historique:
received:
01
12
2022
revised:
27
02
2023
accepted:
13
04
2023
medline:
22
5
2023
pubmed:
22
5
2023
entrez:
22
5
2023
Statut:
epublish
Résumé
Inositol-requiring enzyme 1 (IRE1) is a major mediator of the unfolded protein response (UPR), which is activated upon endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse microenvironmental cues, a stress overcome by relying on IRE1 signaling as an adaptive mechanism. Herein, we report the discovery of structurally new IRE1 inhibitors identified through the structural exploration of its kinase domain. Characterization in
Identifiants
pubmed: 37216120
doi: 10.1016/j.isci.2023.106687
pii: S2589-0042(23)00764-2
pmc: PMC10192531
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106687Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
L.A.E. and E.C. are founders of Cell Stress Discoveries Ltd. A.C. is a founder of e-NIOS Applications PC (https://e-nios.com/). L.A.E. is founder of ANYO Labs (www.anyoloabs.com). E.C. is founder of Thabor therapeutics (https://www.thabor-tx.com/). A patent (PCT/EP2023/050228) cover the discovery in this work.
Références
Nat Immunol. 2019 Sep;20(9):1100-1109
pubmed: 31358997
Sci Rep. 2017 Mar 03;7:42717
pubmed: 28256516
Sci Signal. 2017 Mar 14;10(470):
pubmed: 28292956
Oncotarget. 2015 Dec 1;6(38):40692-703
pubmed: 26517687
Int J Cell Biol. 2010;2010:830307
pubmed: 20169136
Brain Pathol. 2012 Mar;22(2):159-74
pubmed: 21790828
J Cell Sci. 2012 Sep 15;125(Pt 18):4278-87
pubmed: 22718352
Nat Chem Biol. 2012 Dec;8(12):982-9
pubmed: 23086298
ACS Chem Biol. 2020 Dec 18;15(12):3106-3111
pubmed: 33290055
Oncotarget. 2015 Sep 22;6(28):24922-34
pubmed: 26325176
Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78
pubmed: 22315414
Nat Commun. 2019 Jan 24;10(1):323
pubmed: 30679434
Oncotarget. 2016 Apr 5;7(14):18736-49
pubmed: 26934650
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Blood. 2012 Aug 2;120(5):1027-38
pubmed: 22692508
J Med Chem. 2006 Oct 19;49(21):6177-96
pubmed: 17034125
Nat Rev Drug Discov. 2013 Sep;12(9):703-19
pubmed: 23989796
Trends Cancer. 2020 Dec;6(12):1018-1030
pubmed: 32861679
Drug Discov Today. 2006 Dec;11(23-24):1046-53
pubmed: 17129822
EMBO Mol Med. 2018 Mar;10(3):
pubmed: 29311133
Nat Chem Biol. 2019 Nov;15(11):1129
pubmed: 31439938
Methods Mol Biol. 2015;1292:177-94
pubmed: 25804756
J Neurooncol. 2021 Jan;151(1):41-53
pubmed: 32253714
Blood. 2012 Jun 14;119(24):5772-81
pubmed: 22538852
J Med Chem. 2021 Sep 23;64(18):13152-13173
pubmed: 34505508
Nat Commun. 2023 Jan 9;14(1):120
pubmed: 36624093
Nucleic Acids Res. 2021 Jan 8;49(D1):D325-D334
pubmed: 33290552
J Biol Chem. 2013 Nov 15;288(46):33272-82
pubmed: 24100031
SLAS Discov. 2017 Aug;22(7):787-800
pubmed: 28453376
Cancer Res. 2007 Jul 15;67(14):6700-7
pubmed: 17638880
Cells. 2020 Apr 16;9(4):
pubmed: 32316221
Nat Commun. 2018 Aug 15;9(1):3267
pubmed: 30111846
EMBO Mol Med. 2015 Apr 11;7(6):788-801
pubmed: 25864123
Blood Cancer J. 2012 Jul;2(7):e79
pubmed: 22852048
Nat Commun. 2014 Apr 07;5:3554
pubmed: 24704861
BMC Bioinformatics. 2006 Jan 10;7:11
pubmed: 16403211
Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15553-8
pubmed: 20702765
ChemMedChem. 2016 Jun 6;11(11):1117-21
pubmed: 27218427
Bioinformatics. 2006 Nov 15;22(22):2825-7
pubmed: 16982708
Cancer Res. 2020 Jun 1;80(11):2368-2379
pubmed: 32265225
Future Oncol. 2020 Oct;16(28):2251-2264
pubmed: 32744059
FEBS J. 2021 Feb;288(3):945-960
pubmed: 32446294
Mol Cancer Res. 2018 May;16(5):745-753
pubmed: 29440447
J Chem Inf Model. 2015 Nov 23;55(11):2324-37
pubmed: 26479676
J Comput Chem. 2005 Dec;26(16):1752-80
pubmed: 16211539
J Biol Chem. 2020 Nov 13;295(46):15692-15711
pubmed: 32887796
Ann Oncol. 2008 Jun;19(6):1160-5
pubmed: 18326520
Cancer Lett. 2020 Dec 1;494:73-83
pubmed: 32882336
Neurosurg Focus. 2021 Feb;50(2):E3
pubmed: 33524946
ACS Chem Biol. 2016 Aug 19;11(8):2195-205
pubmed: 27227314
Genes Dev. 1998 Jun 15;12(12):1812-24
pubmed: 9637683
Nat Commun. 2020 May 14;11(1):2401
pubmed: 32409639
N Engl J Med. 2005 Mar 10;352(10):987-96
pubmed: 15758009
Comput Struct Biotechnol J. 2022 Mar 29;20:1584-1592
pubmed: 35465159
Biochem J. 2021 Aug 13;478(15):2953-2975
pubmed: 34375386