A blood and bronchoalveolar lavage protein signature of rapid FEV

Humans Lung Disease Progression Pulmonary Disease, Chronic Obstructive Smoking / adverse effects Forced Expiratory Volume Bronchoalveolar Lavage Biomarkers

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
22 05 2023
Historique:
received: 31 08 2022
accepted: 24 03 2023
medline: 24 5 2023
pubmed: 23 5 2023
entrez: 22 5 2023
Statut: epublish

Résumé

Accelerated progression of chronic obstructive pulmonary disease (COPD) is associated with increased risks of hospitalization and death. Prognostic insights into mechanisms and markers of progression could facilitate development of disease-modifying therapies. Although individual biomarkers exhibit some predictive value, performance is modest and their univariate nature limits network-level insights. To overcome these limitations and gain insights into early pathways associated with rapid progression, we measured 1305 peripheral blood and 48 bronchoalveolar lavage proteins in individuals with COPD [n = 45, mean initial forced expiratory volume in one second (FEV

Identifiants

DOI: 10.1038/s41598-023-32216-0 PMID: 37217548 PMC: PMC10203309
pubmed: 37217548
doi: 10.1038/s41598-023-32216-0
pii: 10.1038/s41598-023-32216-0
pmc: PMC10203309
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8228

Subventions

Organisme : CSRD VA
ID : I01 CX001553
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005605
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Katarina M DiLillo (KM)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Katy C Norman (KC)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Christine M Freeman (CM)

Research Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Division of Pulmonary & Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA.

Stephanie A Christenson (SA)

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.

Neil E Alexis (NE)

Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Wayne H Anderson (WH)

Marsico Lung Institute/Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Igor Z Barjaktarevic (IZ)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

R Graham Barr (RG)

Department of Medicine, Columbia University Medical Center, New York, NY, USA.

Alejandro P Comellas (AP)

Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa, Iowa City, IA, USA.

Eugene R Bleecker (ER)

Division of Genetics, Genomics and Precision Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.

Richard C Boucher (RC)

Marsico Lung Institute/Cystic Fibrosis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

David J Couper (DJ)

Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Gerard J Criner (GJ)

Department of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, USA.

Claire M Doerschuk (CM)

Marsico Lung Institute/Cystic Fibrosis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

J Michael Wells (JM)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

MeiLan K Han (MK)

Division of Pulmonary & Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.

Eric A Hoffman (EA)

Department of Radiology, University of Iowa, Iowa City, IA, USA.

Nadia N Hansel (NN)

Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Annette T Hastie (AT)

Department of Internal Medicine, Wake Forest School of Medicine, Atrium Health, Wake Forest Baptist, Winston Salem, NC, USA.

Robert J Kaner (RJ)

Department of Medicine, Weill Cornell Medical Center, New York, NY, USA.

Jerry A Krishnan (JA)

Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL, USA.

Wassim W Labaki (WW)

Division of Pulmonary & Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.

Fernando J Martinez (FJ)

Department of Medicine, Weill Cornell Medical Center, New York, NY, USA.

Deborah A Meyers (DA)

Division of Genetics, Genomics and Precision Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.

Wanda K O'Neal (WK)

Marsico Lung Institute/Cystic Fibrosis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Victor E Ortega (VE)

Department of Internal Medicine, Division of Respiratory Medicine, Mayo Clinic, Scottsdale, AZ, USA.

Robert Paine (R)

Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City, UT, USA.

Stephen P Peters (SP)

Department of Internal Medicine, Wake Forest School of Medicine, Atrium Health, Wake Forest Baptist, Winston Salem, NC, USA.

Prescott G Woodruff (PG)

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.

Christopher B Cooper (CB)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Russell P Bowler (RP)

Division of Pulmonary and Critical Care, National Jewish Health, Denver, CO, USA.

Jeffrey L Curtis (JL)

Division of Pulmonary & Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA.
Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.

Kelly B Arnold (KB)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. kbarnold@umich.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A blood and bronchoalveolar lavage protein...
questionsmedicales.fr › Appareil respiratoire › Poumon › A blood and bronchoalveolar lavage protein...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › A blood and bronchoalveolar lavage protein...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Broncho-pneumopathie chronique obstructive › A blood and bronchoalveolar lavage protein...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Fumer › A blood and bronchoalveolar lavage protein...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Ventilation pulmonaire › Volume expiratoire maximal par seconde › A blood and bronchoalveolar lavage protein...
questionsmedicales.fr › Techniques d'investigation › Irrigation thérapeutique › Lavage bronchoalvéolaire › A blood and bronchoalveolar lavage protein...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › A blood and bronchoalveolar lavage protein...