Executive function mediates age-related variation in social integration in female vervet monkeys (Chlorocebus sabaeus).

Aging Cognition Nonhuman primates Physical function Social integration

Journal

GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284

Informations de publication

Date de publication:
23 May 2023
Historique:
received: 03 10 2022
accepted: 03 05 2023
medline: 23 5 2023
pubmed: 23 5 2023
entrez: 22 5 2023
Statut: aheadofprint

Résumé

In humans, social participation and integration wane with advanced age, a pattern hypothesized to stem from cognitive or physical decrements. Similar age-related decreases in social participation have been observed in several nonhuman primate species. Here, we investigated cross-sectional age-related associations between social interactions, activity patterns, and cognitive function in 25 group-living female vervets (a.k.a. African green monkeys, Chlorocebus sabaeus) aged 8-29 years. Time spent in affiliative behavior decreased with age, and time spent alone correspondingly increased. Furthermore, time spent grooming others decreased with age, but the amount of grooming received did not. The number of social partners to whom individuals directed grooming also decreased with age. Grooming patterns mirrored physical activity levels, which also decreased with age. The relationship between age and grooming time was mediated, in part, by cognitive performance. Specifically, executive function significantly mediated age's effect on time spent in grooming interactions. In contrast, we did not find evidence that physical performance mediated age-related variation in social participation. Taken together, our results suggest that aging female vervets were not socially excluded but decreasingly engaged in social behavior, and that cognitive deficits may underlie this relationship.

Identifiants

pubmed: 37217631
doi: 10.1007/s11357-023-00820-7
pii: 10.1007/s11357-023-00820-7
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIA NIH HHS
ID : RF1AG058829
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072947
Pays : United States
Organisme : NIA NIH HHS
ID : T32AG033534
Pays : United States
Organisme : NIA NIH HHS
ID : R24AG073199
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1TR001420
Pays : United States

Informations de copyright

© 2023. The Author(s), under exclusive licence to American Aging Association.

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Auteurs

Jacob D Negrey (JD)

Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157-1040, USA.

Brett M Frye (BM)

Department of Biology, Emory and Henry College, Emory, VA, USA.
Wake Forest Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Department of Internal Medicine/Gerontology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Suzanne Craft (S)

Wake Forest Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Department of Internal Medicine/Gerontology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Thomas C Register (TC)

Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157-1040, USA.
Wake Forest Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Mark G Baxter (MG)

Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157-1040, USA.
Department of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Matthew J Jorgensen (MJ)

Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157-1040, USA.

Carol A Shively (CA)

Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157-1040, USA. cshively@wakehealth.edu.
Wake Forest Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA. cshively@wakehealth.edu.

Classifications MeSH