Blockage of Osteopontin-Integrin β3 Signaling in Infrapatellar Fat Pad Attenuates Osteoarthritis in Mice.
infrapatellar fat pad
integrin β3
nanogel
osteoarthritis
osteopontin
siRNA
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
09
04
2023
received:
09
02
2023
medline:
7
8
2023
pubmed:
23
5
2023
entrez:
23
5
2023
Statut:
ppublish
Résumé
The knowledge of osteoarthritis (OA) has nowadays been extended from a focalized cartilage disorder to a multifactorial disease. Although recent investigations have reported that infrapatellar fat pad (IPFP) can trigger inflammation in the knee joint, the mechanisms behind the role of IPFP on knee OA progression remain to be defined. Here, dysregulated osteopontin (OPN) and integrin β3 signaling are found in the OA specimens of both human and mice. It is further demonstrated that IPFP-derived OPN participates in OA progression, including activated matrix metallopeptidase 9 in chondrocyte hypertrophy and integrin β3 in IPFP fibrosis. Motivated by these findings, an injectable nanogel is fabricated to provide sustained release of siRNA Cd61 (
Identifiants
pubmed: 37218542
doi: 10.1002/advs.202300897
pmc: PMC10401113
doi:
Substances chimiques
Integrin beta3
0
polyethylene glycol polyethyleneimine nanogel
0
Nanogels
0
Osteopontin
106441-73-0
RNA, Small Interfering
0
Oligopeptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300897Subventions
Organisme : Areas of Excellence
ID : AoE/M-402/20
Organisme : Health and Medical Research Fund of Hong Kong
ID : 18190481
Organisme : Direct Grant of the Chinese University of Hong Kong
ID : 2020.060
Organisme : Mainland-Hong Kong Joint Funding Scheme, Platform
ID : MHP/030/20
Informations de copyright
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Références
Ann Rheum Dis. 2016 Sep;75(9):1714-21
pubmed: 26470720
Artif Cells Nanomed Biotechnol. 2018 Mar;46(2):274-283
pubmed: 28423924
Osteoarthritis Cartilage. 2004;12 Suppl A:S20-30
pubmed: 14698637
Arthritis Rheumatol. 2016 Apr;68(4):826-36
pubmed: 26556499
Joint Bone Spine. 2016 Jul;83(4):389-93
pubmed: 27068617
J Orthop Translat. 2021 Feb 23;28:47-54
pubmed: 33717981
Ann Rheum Dis. 2004 Jul;63(7):881-3
pubmed: 15194590
Ann Rheum Dis. 2011 May;70(5):851-7
pubmed: 21242232
Mol Aspects Med. 2021 Oct;81:101003
pubmed: 34332771
Nat Rev Rheumatol. 2013 Jan;9(1):56-62
pubmed: 23090506
Ann Rheum Dis. 2016 Oct;75(10):1783-8
pubmed: 26612337
Osteoarthritis Cartilage. 2010 Apr;18(4):476-99
pubmed: 20170770
Acc Chem Res. 2012 Jul 17;45(7):985-93
pubmed: 22181582
RNA. 2007 Apr;13(4):431-56
pubmed: 17329355
Arthritis Rheumatol. 2014 Jul;66(7):1820-31
pubmed: 24740822
Sci Transl Med. 2021 Jan 13;13(576):
pubmed: 33441426
J Orthop Res. 2018 Feb 17;:
pubmed: 29453795
J Clin Invest. 2005 Apr;115(4):1060-7
pubmed: 15761492
Elife. 2020 May 22;9:
pubmed: 32441256
Cell Metab. 2020 Nov 3;32(5):801-813.e6
pubmed: 33027637
Arthritis Rheum. 2009 Nov;60(11):3374-7
pubmed: 19877065
Drugs. 2018 Oct;78(15):1625-1631
pubmed: 30251172
Arthritis Res Ther. 2013 Jan 08;15(1):R5
pubmed: 23298463
Nat Rev Drug Discov. 2009 Feb;8(2):129-38
pubmed: 19180106
Nat Rev Rheumatol. 2019 Feb;15(2):77-90
pubmed: 30498258
Nat Commun. 2022 Jan 20;13(1):427
pubmed: 35058428
Adv Drug Deliv Rev. 2006 May 20;58(2):226-42
pubmed: 16574267
Nat Med. 2016 Oct;22(10):1160-1169
pubmed: 27571347
Aging Dis. 2020 Oct 1;11(5):1317-1328
pubmed: 33014539
Mol Diagn Ther. 2020 Feb;24(1):61-68
pubmed: 31792921
Nat Commun. 2015 Aug 14;6:8026
pubmed: 26272817
Exp Mol Med. 2021 Nov;53(11):1689-1696
pubmed: 34848838
Mol Ther. 2020 Mar 4;28(3):723-746
pubmed: 31972133
N Engl J Med. 2017 Aug 31;377(9):819-828
pubmed: 28691885
Osteoarthritis Cartilage. 2008 Jun;16(6):733-9
pubmed: 18077189
Arthritis Care Res (Hoboken). 2012 Apr;64(4):465-74
pubmed: 22563589
Rheumatology (Oxford). 2008 Dec;47(12):1775-9
pubmed: 18854347
Front Bioeng Biotechnol. 2021 Jan 13;8:618399
pubmed: 33520968
Kidney Int. 2009 Jul;76(1):32-43
pubmed: 19357716
Front Med (Lausanne). 2021 May 10;8:661403
pubmed: 34041253
Arthritis Rheumatol. 2021 Dec;73(12):2249-2260
pubmed: 33982891
Adv Sci (Weinh). 2023 Aug;10(22):e2300897
pubmed: 37218542
Osteoarthritis Cartilage. 1999 May;7(3):333
pubmed: 10329320
Cell. 1998 May 1;93(3):411-22
pubmed: 9590175
Osteoarthritis Cartilage. 2021 Feb;29(2):280-289
pubmed: 33246160
Rheumatology (Oxford). 2017 Oct 1;56(10):1784-1793
pubmed: 28957567
Front Cell Dev Biol. 2021 Jun 18;9:693484
pubmed: 34222261
Elife. 2019 Feb 20;8:
pubmed: 30785394
Int J Mol Sci. 2020 Aug 21;21(17):
pubmed: 32825633
Ann Rheum Dis. 2019 Apr;78(4):551-561
pubmed: 30745310
Ann Rheum Dis. 2017 Jun;76(6):1142-1148
pubmed: 28298375
Bioconjug Chem. 2009 May 20;20(5):960-8
pubmed: 19341276
Osteoarthritis Cartilage. 2021 Mar;29(3):380-388
pubmed: 33388431
JCI Insight. 2019 Sep 19;4(18):
pubmed: 31534047
Ann Rheum Dis. 2003 Feb;62(2):108-12
pubmed: 12525378
Ann Rheum Dis. 2016 Feb;75(2):390-5
pubmed: 25488799
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4556-61
pubmed: 11930008
Osteoarthritis Cartilage. 2018 Jul;26(7):864-871
pubmed: 29578044
Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S17-23
pubmed: 20864019
J Clin Invest. 2007 Oct;117(10):2877-88
pubmed: 17823662
Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620964864
pubmed: 33350314
Histopathology. 2006 Oct;49(4):358-64
pubmed: 16978198
Histol Histopathol. 2014 May;29(5):609-18
pubmed: 24135912
Chem Commun (Camb). 2015 Jun 7;51(45):9358-61
pubmed: 25958787
Best Pract Res Clin Rheumatol. 2011 Dec;25(6):751-66
pubmed: 22265258
Expert Opin Investig Drugs. 2018 Apr;27(4):421-426
pubmed: 29569947
Osteoarthritis Cartilage. 2009 Jun;17(6):805-12
pubmed: 19114312
Biomedicines. 2022 Jun 09;10(6):
pubmed: 35740391
Nat Rev Dis Primers. 2016 Oct 13;2:16072
pubmed: 27734845