Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.
breast cancer
circular RNA
drugs
Journal
Non-coding RNA
ISSN: 2311-553X
Titre abrégé: Noncoding RNA
Pays: Switzerland
ID NLM: 101652294
Informations de publication
Date de publication:
19 May 2023
19 May 2023
Historique:
received:
19
01
2023
revised:
02
05
2023
accepted:
16
05
2023
medline:
23
5
2023
pubmed:
23
5
2023
entrez:
23
5
2023
Statut:
epublish
Résumé
Altered expression of circular RNAs (circRNAs) has previously been investigated in breast cancer. However, little is known about the effects of drugs on their regulation and relationship with the cognate linear transcript (linRNA). We analyzed the dysregulation of both 12 cancer-related circRNAs and their linRNAs in two breast cancer cell lines undergoing various treatments. We selected 14 well-known anticancer agents affecting different cellular pathways and examined their impact. Upon drug exposure circRNA/linRNA expression ratios increased, as a result of the downregulation of linRNA and upregulation of circRNA within the same gene. In this study, we highlighted the relevance of identifying the drug-regulated circ/linRNAs according to their oncogenic or anticancer role. Interestingly,
Identifiants
pubmed: 37218992
pii: ncrna9030032
doi: 10.3390/ncrna9030032
pmc: PMC10204552
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : FAR2021
ID : FAR2120348
Organisme : FIR2021
ID : FIR2120538
Références
Cancer Sci. 2019 Jul;110(7):2180-2188
pubmed: 31046163
Anticancer Drugs. 2023 Jan 1;34(1):44-56
pubmed: 36066401
Int J Oncol. 2018 Mar;52(3):743-754
pubmed: 29431182
Environ Toxicol. 2022 Jul;37(7):1597-1607
pubmed: 35234341
Oncogene. 2004 Nov 25;23(55):8950-8
pubmed: 15378002
J Biol Chem. 2004 Jun 25;279(26):27458-65
pubmed: 15105425
Stem Cell Reports. 2018 Mar 13;10(3):1131-1145
pubmed: 29503088
PLoS One. 2021 Nov 9;16(11):e0259669
pubmed: 34752497
Cancer Lett. 2021 Apr 10;503:117-128
pubmed: 33516791
Onco Targets Ther. 2021 Jun 09;14:3671-3685
pubmed: 34135597
PLoS One. 2018 Sep 4;13(9):e0203397
pubmed: 30180179
Mol Cancer Ther. 2012 Apr;11(4):873-87
pubmed: 22294718
Med Sci Monit. 2020 Feb 18;26:e921502
pubmed: 32066649
Mol Biol Cell. 2006 May;17(5):2451-64
pubmed: 16495336
Oncotarget. 2018 Feb 19;9(18):14580-14596
pubmed: 29581865
Epigenomics. 2019 Feb;11(3):297-321
pubmed: 30417652
Cell Death Dis. 2019 Jan 22;10(2):55
pubmed: 30670688
PLoS One. 2015 Aug 25;10(8):e0135410
pubmed: 26305327
Int J Biol Sci. 2021 Jul 22;17(12):3104-3117
pubmed: 34421353
BMC Bioinformatics. 2018 Aug 3;19(1):292
pubmed: 30075703
Drug Discov Today. 2015 Sep;20(9):1152-8
pubmed: 26136161
J Cancer. 2022 Nov 28;13(15):3674-3686
pubmed: 36606192
Front Pharmacol. 2021 Mar 15;12:628690
pubmed: 33790792
Oncotarget. 2016 Dec 6;7(49):80967-80979
pubmed: 27829232
Oncotarget. 2017 Sep 23;8(56):95704-95718
pubmed: 29221160
Autophagy. 2020 Apr;16(4):659-671
pubmed: 31232177
Open Life Sci. 2020 Sep 06;15(1):683-695
pubmed: 33817257
Front Genet. 2018 May 18;9:174
pubmed: 29868122
Mol Cancer. 2020 Sep 11;19(1):142
pubmed: 32917240
Aging (Albany NY). 2021 Mar 3;13(6):8115-8126
pubmed: 33686957
Cancer Manag Res. 2021 Jul 12;13:5573-5585
pubmed: 34285578
Breast Cancer Res Treat. 2021 Jun;187(2):339-347
pubmed: 33844099
Mol Cancer. 2019 Aug 30;18(1):131
pubmed: 31470874
Oncogene. 2000 Jul 27;19(32):3656-64
pubmed: 10951572
Cell. 2019 Feb 7;176(4):869-881.e13
pubmed: 30735636
Pathol Res Pract. 2021 Jul;223:153496
pubmed: 34052769
Mol Cancer. 2021 Jul 29;20(1):98
pubmed: 34325714
J Clin Lab Anal. 2020 Jan;34(1):e22980
pubmed: 31970831
Cancers (Basel). 2020 Oct 15;12(10):
pubmed: 33076429
Onco Targets Ther. 2020 Jan 20;13:549-558
pubmed: 32021297
J Clin Lab Anal. 2021 Jan;35(1):e23575
pubmed: 33159705
Int J Cancer. 2010 Mar 1;126(5):1121-31
pubmed: 19685490
J Drug Target. 2021 Nov;29(9):1004-1015
pubmed: 33775192
Mol Cancer. 2018 Aug 15;17(1):123
pubmed: 30111313
Biochem Biophys Res Commun. 2023 Feb 19;645:61-70
pubmed: 36680938
Clin Cancer Res. 2005 Mar 15;11(6):2169-74
pubmed: 15788663
J Exp Clin Cancer Res. 2017 Oct 16;36(1):145
pubmed: 29037220
Cell Cycle. 2021 Jul;20(13):1320-1333
pubmed: 34152928
Biomedicines. 2022 Mar 21;10(3):
pubmed: 35327527
Biosci Rep. 2019 Jun 25;39(6):
pubmed: 31160488
J Cell Biol. 2020 Jan 6;219(1):
pubmed: 31820782
BMC Cancer. 2019 Jun 10;19(1):555
pubmed: 31182056
Mol Ther Nucleic Acids. 2021 Jul 02;26:63-80
pubmed: 34513294
Cancer Biother Radiopharm. 2021 Sep;36(7):556-567
pubmed: 32833501