Glycolipids in Parkinson's disease: beyond neuronal function.
Parkinson's
central nervous system
glycolipids
immune system
inflammation
intestine
Journal
FEBS open bio
ISSN: 2211-5463
Titre abrégé: FEBS Open Bio
Pays: England
ID NLM: 101580716
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
10
05
2023
received:
13
03
2023
accepted:
22
05
2023
medline:
5
9
2023
pubmed:
23
5
2023
entrez:
23
5
2023
Statut:
ppublish
Résumé
Glycolipid balance is key to normal body function, and its alteration can lead to a variety of diseases involving multiple organs and tissues. Glycolipid disturbances are also involved in Parkinson's disease (PD) pathogenesis and aging. Increasing evidence suggests that glycolipids affect cellular functions beyond the brain, including the peripheral immune system, intestinal barrier, and immunity. Hence, the interplay between aging, genetic predisposition, and environmental exposures could initiate systemic and local glycolipid changes that lead to inflammatory reactions and neuronal dysfunction. In this review, we discuss recent advances in the link between glycolipid metabolism and immune function and how these metabolic changes can exacerbate immunological contributions to neurodegenerative diseases, with a focus on PD. Further understanding of the cellular and molecular mechanisms that control glycolipid pathways and their impact on both peripheral tissues and the brain will help unravel how glycolipids shape immune and nervous system communication and the development of novel drugs to prevent PD and promote healthy aging.
Identifiants
pubmed: 37219461
doi: 10.1002/2211-5463.13651
pmc: PMC10476577
doi:
Substances chimiques
Glycolipids
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1558-1579Informations de copyright
© 2023 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
Références
Eur J Immunol. 2007 Jun;37(6):1431-41
pubmed: 17492806
Orphanet J Rare Dis. 2013 Sep 11;8:140
pubmed: 24020503
Proc Natl Acad Sci U S A. 1995 May 23;92(11):5087-91
pubmed: 7539142
ACS Chem Neurosci. 2019 Oct 16;10(10):4430-4439
pubmed: 31584793
J Biol Chem. 1999 Jul 23;274(30):20916-24
pubmed: 10409636
Arch Pharm Res. 2013 Sep;36(9):1039-50
pubmed: 23771498
J Parkinsons Dis. 2021;11(1):45-60
pubmed: 33074190
Nature. 2014 Jun 5;510(7503):58-67
pubmed: 24899305
Cell Death Dis. 2018 Feb 7;9(2):173
pubmed: 29415989
Cell. 1992 Nov 27;71(5):765-76
pubmed: 1330325
Front Immunol. 2017 Jul 25;8:861
pubmed: 28791019
Korean J Physiol Pharmacol. 2011 Oct;15(5):251-8
pubmed: 22128256
Biomolecules. 2021 Jun 25;11(7):
pubmed: 34202192
J Biol Chem. 2012 Jun 15;287(25):21384-95
pubmed: 22532571
Hum Mol Genet. 2005 Aug 15;14(16):2387-98
pubmed: 16000318
Immunity. 2021 Jan 12;54(1):132-150.e9
pubmed: 33271119
Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23671-23681
pubmed: 31690657
Br J Pharmacol. 2010 Feb 1;159(3):586-603
pubmed: 20067473
Biochemistry. 2007 Feb 20;46(7):1868-77
pubmed: 17253773
Brain. 2012 Jun;135(Pt 6):1724-35
pubmed: 22566609
Front Immunol. 2019 Jan 29;10:90
pubmed: 30761148
Curr Opin Microbiol. 2018 Jun;43:92-99
pubmed: 29328957
Folia Neuropathol. 2014;52(3):260-9
pubmed: 25310737
Neurology. 2012 Feb 7;78(6):417-20
pubmed: 22282650
Front Aging Neurosci. 2020 Mar 10;12:60
pubmed: 32210791
PLoS Biol. 2013;11(3):e1001506
pubmed: 23554574
Front Pharmacol. 2021 Apr 28;12:653842
pubmed: 33995070
J Biol Chem. 2008 Feb 29;283(9):5677-84
pubmed: 18165233
J Exp Med. 2007 Apr 16;204(4):841-52
pubmed: 17389239
Nat Commun. 2020 May 18;11(1):2471
pubmed: 32424203
Cell Rep. 2023 Feb 13;42(2):112104
pubmed: 36787220
J Neurochem. 2017 Dec;143(5):534-550
pubmed: 28940479
Hum Mol Genet. 2011 Aug 1;20(15):3067-78
pubmed: 21558425
Front Pharmacol. 2019 Nov 22;10:1251
pubmed: 31824303
FASEB J. 2020 Dec;34(12):15922-15945
pubmed: 33047400
Neurochem Res. 2017 Feb;42(2):686-696
pubmed: 27943027
Sci Rep. 2019 Dec 18;9(1):19330
pubmed: 31852959
Mol Neurobiol. 2019 Aug;56(8):5436-5455
pubmed: 30612333
J Immunol. 2006 Jul 1;177(1):246-54
pubmed: 16785520
Immunity. 2023 Feb 14;56(2):307-319.e8
pubmed: 36736320
Neuroreport. 1999 Nov 26;10(17):3567-72
pubmed: 10619645
Cell. 2011 Jul 8;146(1):37-52
pubmed: 21700325
Genomics Proteomics Bioinformatics. 2019 Feb;17(1):64-75
pubmed: 31026583
Front Neurosci. 2020 Oct 06;14:572965
pubmed: 33117120
Int J Dev Neurosci. 2013 Dec;31(8):783-9
pubmed: 24113259
N Engl J Med. 2009 Oct 22;361(17):1651-61
pubmed: 19846850
Mol Genet Metab. 2013 Apr;108(4):241-8
pubmed: 23433711
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27646-27654
pubmed: 33060302
Neurochem Res. 2021 Mar;46(3):425-438
pubmed: 33400024
Mol Neurodegener. 2019 Nov 8;14(1):40
pubmed: 31703585
Mol Genet Metab. 2004 Jan;81(1):70-3
pubmed: 14728994
J Neuroinflammation. 2017 Aug 2;14(1):154
pubmed: 28768533
J Mol Biol. 2016 Aug 14;428(16):3325-3336
pubmed: 27261254
Nat Immunol. 2005 Aug;6(8):819-26
pubmed: 16007090
Mov Disord. 2014 Apr;29(4):518-26
pubmed: 24822250
Acta Neuropathol. 1988;75(4):385-90
pubmed: 3364161
J Exp Med. 2006 Oct 2;203(10):2293-303
pubmed: 16982810
Trends Immunol. 2018 May;39(5):380-392
pubmed: 29478771
Arch Immunol Ther Exp (Warsz). 2017 Jun;65(3):263-269
pubmed: 27638481
Int J Mol Sci. 2020 Apr 19;21(8):
pubmed: 32325905
Cell Host Microbe. 2019 May 8;25(5):668-680.e7
pubmed: 31071294
J Neurochem. 2016 Jan;136 Suppl 1:74-80
pubmed: 25946402
Mol Genet Metab. 2012 May;106(1):83-91
pubmed: 22425450
PLoS One. 2021 Oct 25;16(10):e0247211
pubmed: 34695170
Biochim Biophys Acta. 2013 Jun;1831(6):1016-26
pubmed: 23384839
Nat Rev Drug Discov. 2010 Nov;9(11):883-97
pubmed: 21031003
Ann Neurol. 2005 Feb;57(2):176-9
pubmed: 15668963
Biochim Biophys Acta Mol Cell Res. 2021 Feb;1868(2):118915
pubmed: 33271273
Glia. 2019 Oct;67(10):1859-1872
pubmed: 31231866
Front Immunol. 2019 Jun 04;10:1264
pubmed: 31214199
J Neurol Sci. 2013 Jan 15;324(1-2):140-8
pubmed: 23199590
J Neurosci Res. 2012 Oct;90(10):1997-2008
pubmed: 22714832
QJM. 1997 Jan;90(1):19-25
pubmed: 9093585
J Immunol. 2006 Jul 1;177(1):26-30
pubmed: 16785493
J Inherit Metab Dis. 2010 Apr;33(2):167-73
pubmed: 20177787
Mol Neurobiol. 2018 Jan;55(1):763-775
pubmed: 28058580
Bull Exp Biol Med. 2017 Apr;162(6):734-737
pubmed: 28429209
J Oleo Sci. 2011;60(10):537-44
pubmed: 21937853
PLoS One. 2015 Mar 16;10(3):e0120194
pubmed: 25775479
J Neurochem. 2010 May;113(4):904-18
pubmed: 20202085
Int J Mol Sci. 2023 Jan 20;24(3):
pubmed: 36768367
Sci Rep. 2019 Jun 10;9(1):8362
pubmed: 31182727
Int J Mol Sci. 2020 Jan 29;21(3):
pubmed: 32013258
Mol Neurodegener. 2019 Aug 29;14(1):36
pubmed: 31464647
Lancet. 2021 Jun 12;397(10291):2284-2303
pubmed: 33848468
Acta Neuropathol. 2012 Sep;124(3):397-410
pubmed: 22810490
Mediators Inflamm. 2015;2015:509306
pubmed: 26609198
Adv Exp Med Biol. 2010;688:1-23
pubmed: 20919643
Neurobiol Aging. 2018 Jul;67:67-74
pubmed: 29649746
Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3285-E3294
pubmed: 28373578
Nat Commun. 2014 Jun 06;5:4028
pubmed: 24905578
NPJ Parkinsons Dis. 2021 Nov 22;7(1):102
pubmed: 34811369
J Neurochem. 2013 Oct;127(2):245-58
pubmed: 23919525
Nat Immunol. 2005 Aug;6(8):810-8
pubmed: 16007091
Acta Neuropathol Commun. 2020 Nov 9;8(1):189
pubmed: 33168089
Sci Rep. 2016 Mar 31;6:23795
pubmed: 27029648
Biochim Biophys Acta. 1989 Sep 25;1005(2):109-17
pubmed: 2775765
J Clin Invest. 2009 Jan;119(1):182-92
pubmed: 19104149
Antioxid Redox Signal. 2015 Aug 20;23(6):550-64
pubmed: 26094487
Nature. 1994 Dec 15;372(6507):691-4
pubmed: 7527500
BMB Rep. 2020 Jan;53(1):28-34
pubmed: 31818364
J Immunol. 2015 Jun 1;194(11):5437-45
pubmed: 25911753
Am J Pathol. 2011 Aug;179(2):954-63
pubmed: 21801874
Adv Exp Med Biol. 2014;817:39-71
pubmed: 24997029
Cold Spring Harb Perspect Biol. 2015 Jan 05;7(1):a020412
pubmed: 25561720
J Neuroinflammation. 2018 Mar 8;15(1):73
pubmed: 29519253
Neurobiol Dis. 2020 Apr;137:104782
pubmed: 31991247
P T. 2015 Aug;40(8):504-32
pubmed: 26236139
Neuroscience. 2015 Apr 2;290:636-48
pubmed: 25637806
Front Mol Neurosci. 2022 Jan 21;14:744942
pubmed: 35126050
Hum Mol Genet. 2017 Nov 15;26(22):4441-4450
pubmed: 28973645
Nat Cell Biol. 2011 Sep 18;13(10):1189-201
pubmed: 21926990
Neuropharmacology. 2018 Jun;135:139-150
pubmed: 29481916
Nat Commun. 2021 Oct 15;12(1):6021
pubmed: 34654818
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2012-2017
pubmed: 28167760
Curr Neurol Neurosci Rep. 2018 Jun 8;18(8):44
pubmed: 29884970
Sci China Life Sci. 2017 Nov;60(11):1223-1233
pubmed: 28536926
Brain Behav Immun. 2004 Nov;18(6):487-94
pubmed: 15331118
Glia. 2003 Sep;43(3):254-64
pubmed: 12898704
Glia. 2002 Apr 1;38(1):15-23
pubmed: 11921200
Mol Cell Neurosci. 2022 May;120:103729
pubmed: 35447351
J Immunol. 1990 Oct 15;145(8):2616-25
pubmed: 1976699
Nat Immunol. 2019 Dec;20(12):1644-1655
pubmed: 31636468
Brain Res Bull. 1990 Jan;24(1):131-41
pubmed: 2178726
Mol Genet Genomic Med. 2020 Apr;8(4):e1189
pubmed: 32077254
Front Cell Dev Biol. 2020 May 19;8:271
pubmed: 32509770
FASEB J. 2017 Jan;31(1):172-179
pubmed: 27671228
Glia. 2013 Mar;61(3):349-60
pubmed: 23108585
Eur J Immunol. 2012 Jul;42(7):1886-92
pubmed: 22585405
Am J Transl Res. 2020 Mar 15;12(3):1123-1135
pubmed: 32269739
Biomolecules. 2022 Jan 21;12(2):
pubmed: 35204675
Toxicon. 2001 Nov;39(11):1737-46
pubmed: 11595636
J Neuroinflammation. 2022 Jan 6;19(1):9
pubmed: 34991625
Science. 2004 Dec 3;306(5702):1786-9
pubmed: 15539565
J Biol Chem. 2016 Jan 29;291(5):2422-34
pubmed: 26553872
Nat Commun. 2018 Apr 16;9(1):1479
pubmed: 29662056
J Biol Chem. 2016 Sep 23;291(39):20811-21
pubmed: 27528608
QJM. 1996 Sep;89(9):691-4
pubmed: 8917744
Sci Rep. 2019 Aug 20;9(1):12106
pubmed: 31431671
J Med Genet. 2020 Feb;57(2):73-81
pubmed: 31484719
Glia. 2006 Apr 15;53(6):621-30
pubmed: 16470810
PLoS One. 2016 Jan 15;11(1):e0147208
pubmed: 26771826
Mol Ther. 2017 Oct 4;25(10):2404-2414
pubmed: 28927576
J Leukoc Biol. 2008 Mar;83(3):728-41
pubmed: 18055569
J Biol Chem. 1994 Jan 21;269(3):1959-65
pubmed: 7507488
Front Aging Neurosci. 2021 Feb 09;13:605970
pubmed: 33633562
Neurology. 2011 Jun 7;76(23):2002-9
pubmed: 21646627
Sci Rep. 2022 Mar 23;12(1):4977
pubmed: 35323826
Aliment Pharmacol Ther. 2022 Feb;55(3):277-291
pubmed: 34932238
Biochimie. 2011 Jan;93(1):46-51
pubmed: 20868723
Front Neurosci. 2021 Apr 30;15:660379
pubmed: 33994934
Glycoconj J. 2022 Feb;39(1):39-53
pubmed: 34757540
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):751-6
pubmed: 21177428
Dialogues Clin Neurosci. 2009;11(3):281-95
pubmed: 19877496
Oncotarget. 2015 Nov 10;6(35):37043-53
pubmed: 26497684
J Neurol Sci. 2011 Nov 15;310(1-2):12-6
pubmed: 21621226
Nature. 2006 Aug 24;442(7105):916-9
pubmed: 16862116
Glia. 2023 Apr;71(4):1120-1141
pubmed: 36583573
ASN Neuro. 2018 Jan-Dec;10:1759091418781889
pubmed: 29932343
Brain. 2003 Apr;126(Pt 4):974-87
pubmed: 12615653
J Neurol Sci. 2010 May 15;292(1-2):45-51
pubmed: 20206941
J Neurochem. 1966 Apr;13(4):213-22
pubmed: 5937889
Stem Cell Reports. 2016 Mar 8;6(3):342-56
pubmed: 26905200
Int J Mol Sci. 2015 Dec 28;17(1):
pubmed: 26729092
Front Physiol. 2020 Dec 22;11:593026
pubmed: 33414722
Clin Immunol. 2010 Mar;134(3):277-88
pubmed: 19900843
Arch Med Res. 2014 Nov;45(8):687-97
pubmed: 25431839
Transl Neurodegener. 2015 Nov 03;4:21
pubmed: 26535116
Blood Cells Mol Dis. 2018 Feb;68:47-53
pubmed: 28003098
Nat Commun. 2022 May 3;13(1):2406
pubmed: 35504893
J Neural Transm (Vienna). 2017 Aug;124(8):901-905
pubmed: 28150045
Vascul Pharmacol. 2002 Jun;38(6):315-22
pubmed: 12529926
Cell Rep. 2018 Jun 5;23(10):2976-2988
pubmed: 29874584
Eur J Biochem. 1997 Oct 1;249(1):239-47
pubmed: 9363775
J Immunol. 2012 Sep 15;189(6):3007-17
pubmed: 22875802
Clin Genet. 1985 May;27(5):443-50
pubmed: 3924448
Biochem Biophys Res Commun. 2020 Sep 3;529(4):1137-1144
pubmed: 32819577
J Neuroinflammation. 2013 Jun 21;10:75
pubmed: 23786632
J Neurol Sci. 2013 Dec 15;335(1-2):219-20
pubmed: 24035292
J Neurosci. 2004 Jun 30;24(26):5942-54
pubmed: 15229242
Ann Neurol. 2012 Sep;72(3):455-63
pubmed: 23034917
Mediators Inflamm. 2016;2016:9890141
pubmed: 27656050
Neurobiol Dis. 2018 Dec;120:1-11
pubmed: 30149180
J Neurol Neurosurg Psychiatry. 2018 Jul;89(7):702-709
pubmed: 29378790
FEBS Open Bio. 2016 Jul 30;6(9):902-13
pubmed: 27642553
Nat Immunol. 2017 Jun 20;18(7):716-724
pubmed: 28632714
J Clin Invest. 2018 Jul 2;128(7):2702-2712
pubmed: 30108193
J Neuropathol Exp Neurol. 2004 Apr;63(4):323-8
pubmed: 15099022
Ann Neurol. 2021 Mar;89(3):546-559
pubmed: 33274480
Mov Disord. 2021 May;36(5):1216-1228
pubmed: 33547828
Nature. 2017 Mar 2;543(7643):108-112
pubmed: 28225753
J Parkinsons Dis. 2021;11(1):221-232
pubmed: 33216044
Inflammation. 2019 Aug;42(4):1170-1178
pubmed: 30793225
Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1573-1582
pubmed: 28315304
Cell Stem Cell. 2018 Jul 05;23(1):123-131.e6
pubmed: 29979986
Science. 1997 Jul 18;277(5324):339-45
pubmed: 9219685
Blood. 2015 Feb 19;125(8):1256-71
pubmed: 25499455
Mol Neurodegener. 2020 Oct 17;15(1):59
pubmed: 33069254