Acquired idiopathic isolated ACTH deficiency with associated autoimmune thyroiditis in pediatrics: case report and review of the literature.
adrenal insufficiency
autoimmune thyroiditis
hypoglycemia
idiopathic isolated ACTH deficiency
Journal
Journal of pediatric endocrinology & metabolism : JPEM
ISSN: 2191-0251
Titre abrégé: J Pediatr Endocrinol Metab
Pays: Germany
ID NLM: 9508900
Informations de publication
Date de publication:
26 Jul 2023
26 Jul 2023
Historique:
received:
24
02
2023
accepted:
14
05
2023
medline:
10
7
2023
pubmed:
24
5
2023
entrez:
24
5
2023
Statut:
epublish
Résumé
Isolated ACTH deficiency (IAD) is defined as an impaired secretion of ACTH from the pituitary gland without any other anterior pituitary hormonal deficits. The idiopathic form of IAD has been described mainly in adults and is thought to be caused by an autoimmune mechanism. Herein, we present an 11-year-old _prepubertal previously healthy boy, who suffered a severe hypoglycemic episode short after the initiation of thyroxine for autoimmune thyroiditis and was finally diagnosed with secondary adrenal failure due to idiopathic IAD, after all other etiologies were excluded, thought an extensive diagnostic work-up. Idiopathic IAD is a rare entity of adrenal insufficiency in pediatrics that should be considered as an etiology of secondary adrenal failure in children, when clinical signs of glucocorticoid deficiency are present and other causes are excluded.
Identifiants
pubmed: 37222702
pii: jpem-2023-0080
doi: 10.1515/jpem-2023-0080
doi:
Substances chimiques
Adrenocorticotropic Hormone
9002-60-2
Types de publication
Review
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
700-703Informations de copyright
© 2023 Walter de Gruyter GmbH, Berlin/Boston.
Références
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