SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19.
Journal
Research (Washington, D.C.)
ISSN: 2639-5274
Titre abrégé: Research (Wash D C)
Pays: United States
ID NLM: 101747148
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
12
2022
accepted:
28
03
2023
medline:
24
5
2023
pubmed:
24
5
2023
entrez:
24
5
2023
Statut:
epublish
Résumé
The COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health burden. Severe cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic-thrombocytopenia (VITT) are both associated with thrombosis and thrombocytopenia; however, the underlying mechanisms remain inadequately understood. Both infection and vaccination utilize the spike protein receptor-binding domain (RBD) of SARS-CoV-2. We found that intravenous injection of recombinant RBD caused significant platelet clearance in mice. Further investigation revealed the RBD could bind platelets, cause platelet activation, and potentiate platelet aggregation, which was exacerbated in the Delta and Kappa variants. The RBD-platelet interaction was partially dependent on the β3 integrin as binding was significantly reduced in β3
Identifiants
pubmed: 37223472
doi: 10.34133/research.0124
pii: 0124
pmc: PMC10202384
doi:
Types de publication
Journal Article
Langues
eng
Pagination
0124Informations de copyright
Copyright © 2023 Xiaoying Ma et al.
Références
Blood. 2017 Mar 30;129(13):1840-1854
pubmed: 28122739
J Thromb Haemost. 2020 Jun;18(6):1469-1472
pubmed: 32302435
Nat Commun. 2015 Jul 17;6:7737
pubmed: 26185093
JACC Basic Transl Sci. 2021 Jan;6(1):1-8
pubmed: 33102950
Lancet. 2021 Jun 26;397(10293):2461-2462
pubmed: 34139198
Cardiovasc Hematol Disord Drug Targets. 2020;20(4):260-273
pubmed: 33001021
Viruses. 2021 Jan 20;13(2):
pubmed: 33498225
Curr Opin Hematol. 2015 Sep;22(5):445-51
pubmed: 26154508
Blood. 2014 Jul 31;124(5):791-802
pubmed: 24755410
Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1635-1650
pubmed: 32434410
Talanta. 2020 Sep 1;217:121022
pubmed: 32498850
Blood. 2018 Feb 15;131(7):787-796
pubmed: 29203584
Nat Commun. 2018 Sep 6;9(1):3608
pubmed: 30190457
Nature. 2021 Jul;595(7865):17-18
pubmed: 34158664
Cell Death Differ. 2021 Nov;28(11):3009-3021
pubmed: 33993195
Transfus Apher Sci. 2003 Jun;28(3):257-64
pubmed: 12725952
Hepatology. 2022 Dec;76(6):1576-1586
pubmed: 35567545
Exp Hematol. 2016 Oct;44(10):924-930.e1
pubmed: 27417974
Nat Immunol. 2021 Nov;22(11):1352-1353
pubmed: 34686863
J Biol Chem. 2022 Mar;298(3):101710
pubmed: 35150743
J Biomed Res. 2015 Oct 30;29:
pubmed: 26541706
Curr Opin Hematol. 2018 Sep;25(5):373-381
pubmed: 30015642
J Hematol Oncol. 2017 May 11;10(1):104
pubmed: 28494777
PLoS One. 2012;7(5):e37323
pubmed: 22624015
Nat Med. 2011 Nov 07;17(11):1423-36
pubmed: 22064432
Thromb J. 2023 Feb 13;21(1):18
pubmed: 36782235
Thromb J. 2021 Aug 23;19(1):59
pubmed: 34425822
Blood. 2006 Apr 1;107(7):2976-83
pubmed: 16317099
Circ Res. 2020 Sep 17;:
pubmed: 32938299
Ann Vasc Surg Brief Rep Innov. 2022 Sep;2(3):100101
pubmed: 35784811
Food Funct. 2020 Jan 29;11(1):139-152
pubmed: 31755492
J Thromb Haemost. 2021 Jan;19(1):46-50
pubmed: 33119197
J Clin Invest. 2011 Nov;121(11):4537-47
pubmed: 22019589
BMJ. 2021 Oct 14;375:n2400
pubmed: 34649864
Intensive Care Med. 2020 Apr;46(4):586-590
pubmed: 32125455
Clin Neuroradiol. 2021 Jun;31(2):511-514
pubmed: 33512534
Lancet Haematol. 2020 Sep;7(9):e671-e678
pubmed: 32659214
J Hepatol. 2020 Nov;73(5):1231-1240
pubmed: 32553666
Transfusion. 2012 Jul;52(7):1446-57
pubmed: 22251227
JAMA Netw Open. 2020 Jul 1;3(7):e2015957
pubmed: 32697325
Biochem Biophys Res Commun. 2022 Jan 29;590:34-41
pubmed: 34968782
Blood. 2006 Aug 1;108(3):943-6
pubmed: 16861348
Front Pharmacol. 2021 Jul 05;12:708665
pubmed: 34290613
Pediatr Blood Cancer. 2022 Aug;69(8):e29721
pubmed: 35441478
Blood. 2020 Sep 10;136(11):1330-1341
pubmed: 32678428
N Engl J Med. 2021 Jun 10;384(23):2202-2211
pubmed: 33861525
Pathobiology. 2021;88(1):15-27
pubmed: 33049751
Intensive Care Med. 2020 Jun;46(6):1089-1098
pubmed: 32367170
Emerg Infect Dis. 2020 Sep;26(9):2054-2063
pubmed: 32558639
J Clin Invest. 2014 Oct;124(10):4281-93
pubmed: 25180602
J Hematol Oncol. 2020 Sep 4;13(1):120
pubmed: 32887634
Nat Rev Immunol. 2011 Apr;11(4):264-74
pubmed: 21436837
Blood. 2018 Aug 9;132(6):622-634
pubmed: 29794068
Blood. 2020 Sep 10;136(11):1317-1329
pubmed: 32573711
Semin Thromb Hemost. 2006 Apr;32 Suppl 1:32-8
pubmed: 16673264
Cell. 2002 Sep 20;110(6):673-87
pubmed: 12297042
Mol Nutr Food Res. 2019 Dec;63(23):e1900662
pubmed: 31512815
Antiviral Res. 2020 May;177:104759
pubmed: 32130973
J Thromb Haemost. 2006 Oct;4(10):2230-7
pubmed: 16824188
Thromb J. 2016 Oct 4;14(Suppl 1):29
pubmed: 27766055
Emerg Microbes Infect. 2020 Dec;9(1):601-604
pubmed: 32178593
J Hematol Oncol. 2021 Apr 29;14(1):72
pubmed: 33926500
Crit Care Resusc. 2020 Apr 15;22(2):95-97
pubmed: 32294809
Euro Surveill. 2021 Apr;26(16):
pubmed: 33890566
Am J Blood Res. 2022 Apr 15;12(2):60-63
pubmed: 35603125
Signal Transduct Target Ther. 2020 Dec 4;5(1):283
pubmed: 33277466
Nature. 2021 Aug;596(7873):565-569
pubmed: 34233346
Thromb Haemost. 2013 Dec;110(6):1250-8
pubmed: 24067944
N Engl J Med. 2021 Jun 3;384(22):2092-2101
pubmed: 33835769
Nat Rev Cardiol. 2021 Mar;18(3):194-209
pubmed: 33214651
J Hepatol. 2021 Sep;75(3):647-658
pubmed: 33991637
Front Immunol. 2020 Aug 07;11:1962
pubmed: 32849656
Cell. 1992 Apr 3;69(1):11-25
pubmed: 1555235
Blood. 2020 Aug 20;136(8):974-988
pubmed: 32584951
J Hematol Oncol. 2017 Feb 8;10(1):46
pubmed: 28179000
J Hematol Oncol. 2020 Dec 1;13(1):161
pubmed: 33261634
Blood. 2009 Jul 9;114(2):425-36
pubmed: 19332769
N Engl J Med. 2021 Jun 3;384(22):2124-2130
pubmed: 33835768
Sci Rep. 2021 Jun 3;11(1):11663
pubmed: 34083615
Blood. 2015 Jul 9;126(2):247-56
pubmed: 26036802
Res Pract Thromb Haemost. 2021 May 03;5(4):e12506
pubmed: 33977209
Arch Virol. 2015 Nov;160(11):2669-81
pubmed: 26321473
Crit Rev Clin Lab Sci. 2016 Dec;53(6):409-30
pubmed: 27282765
Circ Res. 2022 Jan 21;130(2):288-308
pubmed: 35050690
Haematologica. 2014 Apr;99(4):e61-3
pubmed: 24532041
Nat Rev Immunol. 2021 Dec;21(12):753-755
pubmed: 34663971
J Vasc Surg. 2022 Nov;76(5):1374-1382.e1
pubmed: 35700857
J Exp Med. 2020 Apr 6;217(4):
pubmed: 31978220
Blood. 2009 Feb 19;113(8):1809-17
pubmed: 19036705
Circulation. 2020 Nov 24;142(21):2080-2082
pubmed: 33054349
Viruses. 2022 Mar 29;14(4):
pubmed: 35458435
Circ Res. 2021 Sep 3;129(6):631-646
pubmed: 34293929
Mol Biol Cell. 2022 Dec 1;33(14):ar147
pubmed: 36287912
J Biol Chem. 2023 Mar;299(3):102922
pubmed: 36669646