Tocilizumab in the Treatment of Eosinophilic Fasciitis: A Case Study and Review of Literature.
Shulman’s disease
eosinophilic fasciitis
tocilizumab
Journal
Mediterranean journal of rheumatology
ISSN: 2529-198X
Titre abrégé: Mediterr J Rheumatol
Pays: Greece
ID NLM: 101730166
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
25
07
2022
revised:
21
10
2022
accepted:
25
10
2022
medline:
24
5
2023
pubmed:
24
5
2023
entrez:
24
5
2023
Statut:
epublish
Résumé
Eosinophilic fasciitis (EF) is a rare connective-tissue disorder that is characterised by subacute onset of erythema, oedema, and induration of the skin and soft tissues of the limbs and trunk. Although several triggers have been hypothesised to be associated with EF, the aetiology of eosinophilic fasciitis (EF) is still unclear, and several treatment regimens have been proposed to treat this disease. In this article, we report a case of a 72-year-old gentleman with multiple comorbidities who presented to the clinic for diffuse skin thickening present on his forearms, thighs, legs bilaterally, and over the pelvis. The patient was diagnosed with EF and failed multiple treatment regimens including prednisone, methotrexate, rituximab, but finally responded and was maintained on tocilizumab. In this article, we will review the current understanding of EF, diagnostic approach, popular treatments and review other cases of EF in which tocilizumab was used.
Identifiants
pubmed: 37223590
doi: 10.31138/mjr.34.1.78
pii: MJR-34-1-78
pmc: PMC10201092
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
78-85Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2023 The Mediterranean Journal of Rheumatology (MJR).
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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