An archaeal Cas3 protein facilitates rapid recovery from DNA damage.
CRISPR
Cas3
DNA-repair
archaea
haloferax
recombination
Journal
microLife
ISSN: 2633-6693
Titre abrégé: Microlife
Pays: England
ID NLM: 9918227365406676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
12
2022
accepted:
08
02
2023
medline:
24
5
2023
pubmed:
24
5
2023
entrez:
24
5
2023
Statut:
epublish
Résumé
CRISPR-Cas systems provide heritable acquired immunity against viruses to archaea and bacteria. Cas3 is a CRISPR-associated protein that is common to all Type I systems, possesses both nuclease and helicase activities, and is responsible for degradation of invading DNA. Involvement of Cas3 in DNA repair had been suggested in the past, but then set aside when the role of CRISPR-Cas as an adaptive immune system was realized. Here we show that in the model archaeon
Identifiants
pubmed: 37223740
doi: 10.1093/femsml/uqad007
pii: uqad007
pmc: PMC10117719
doi:
Types de publication
Journal Article
Langues
eng
Pagination
uqad007Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of FEMS.
Déclaration de conflit d'intérêts
None declared.
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