Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation.

Phosphorylation Ryanodine Receptor Calcium Release Channel Cryoelectron Microscopy Cyclic AMP-Dependent Protein Kinases Scorpion Venoms / pharmacology

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
24 05 2023
Historique:
medline: 26 5 2023
pubmed: 24 5 2023
entrez: 24 5 2023
Statut: ppublish

Résumé

Calcins are peptides from scorpion venom with the unique ability to cross cell membranes, gaining access to intracellular targets. Ryanodine Receptors (RyR) are intracellular ion channels that control release of Ca

Identifiants

DOI: 10.1126/sciadv.adf4936 PMID: 37224245 PMC: PMC10208580
pubmed: 37224245
doi: 10.1126/sciadv.adf4936
pmc: PMC10208580
doi:

Substances chimiques

Ryanodine Receptor Calcium Release Channel 0
Cyclic AMP-Dependent Protein Kinases EC 2.7.11.11
Scorpion Venoms 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadf4936

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL167195
Pays : United States

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Auteurs

Omid Haji-Ghassemi (O)

Department of Biochemistry and Molecular Biology, Life Sciences Centre, University of British Columbia, Vancouver, BC, Canada.
ORCID: 0000-0003-0116-005X

Yu Seby Chen (YS)

Department of Biochemistry and Molecular Biology, Life Sciences Centre, University of British Columbia, Vancouver, BC, Canada.
ORCID: 0000-0002-0793-2391

Kellie Woll (K)

Department of Biochemistry and Molecular Biology, Life Sciences Centre, University of British Columbia, Vancouver, BC, Canada.

Georgina B Gurrola (GB)

Universidad Nacional Autónoma de México, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotechnología, Cuaernavaca, Morelos 62271, Mexico.
ORCID: 0000-0002-8107-4145

Carmen R Valdivia (CR)

Department of Medicine and Cardiovascular Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
ORCID: 0000-0003-1224-3088

Wenxuan Cai (W)

Department of Medicine and Cardiovascular Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.

Songhua Li (S)

Department of Cardiology, Changhai Hospital, Naval Medical University, Shanghai, China.

Hector H Valdivia (HH)

Department of Medicine and Cardiovascular Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
ORCID: 0000-0003-1231-6267

Filip Van Petegem (F)

Department of Biochemistry and Molecular Biology, Life Sciences Centre, University of British Columbia, Vancouver, BC, Canada.
ORCID: 0000-0003-2728-8537

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Phosphorylation › Cryo-EM analysis of scorpion toxin binding to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canal de libération du calcium du récepteur à la ryanodine › Cryo-EM analysis of scorpion toxin binding to...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Cryo-EM analysis of scorpion toxin binding to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Cyclic Nucleotide-Regulated Protein Kinases › Cyclic AMP-Dependent Protein Kinases › Cryo-EM analysis of scorpion toxin binding to...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins d'arthropode › Venins de scorpion › Cryo-EM analysis of scorpion toxin binding to...