A Liquid Biopsy-Based Approach to Isolate and Characterize Adipose Tissue-Derived Extracellular Vesicles from Blood.

adipose tissue amino acid metabolism extracellular vesicles inflammation liquid biopsies microRNA obesity

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
13 06 2023
Historique:
pmc-release: 13 06 2024
medline: 15 6 2023
pubmed: 24 5 2023
entrez: 24 5 2023
Statut: ppublish

Résumé

Obesity is a major risk factor for multiple chronic diseases. Anthropometric and imaging approaches are primarily used to assess adiposity, and there is a dearth of techniques to determine the changes in adipose tissue (AT) at the molecular level. Extracellular vesicles (EVs) have emerged as a novel and less invasive source of biomarkers for various pathologies. Furthermore, the possibility of enriching cell or tissue-specific EVs from the biofluids based on their unique surface markers has led to classifying these vesicles as "liquid biopsies", offering valuable molecular information on hard-to-access tissues. Here, we isolated small EVs from AT (sEV

Identifiants

pubmed: 37224410
doi: 10.1021/acsnano.3c00422
pmc: PMC10713009
mid: NIHMS1914072
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

10252-10268

Subventions

Organisme : NIA NIH HHS
ID : R01 AG061805
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA012197
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG070371
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG075611
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG021332
Pays : United States

Références

Endocrinology. 2018 Sep 1;159(9):3259-3267
pubmed: 30016424
Diabetes. 2020 Sep;69(9):1903-1916
pubmed: 32586980
Cell Metab. 2011 Jan 5;13(1):11-22
pubmed: 21195345
Diabetologia. 2006 Nov;49(11):2599-603
pubmed: 16969645
Crit Rev Clin Lab Sci. 2001 Aug;38(4):263-355
pubmed: 11563810
Aging (Albany NY). 2020 Dec 3;13(1):1357-1368
pubmed: 33293478
Mol Cell Endocrinol. 2021 Jun 1;529:111256
pubmed: 33798634
Nat Rev Drug Discov. 2008 Jun;7(6):489-503
pubmed: 18511927
Oncotarget. 2015 Sep 8;6(26):22836-56
pubmed: 26087400
Circ Res. 2005 May 13;96(9):939-49
pubmed: 15890981
Nat Med. 2005 Feb;11(2):183-90
pubmed: 15685173
Br J Nutr. 2007 Oct;98 Suppl 1:S121-6
pubmed: 17922949
Oncotarget. 2017 Feb 7;8(6):9899-9910
pubmed: 28038441
Int J Obes (Lond). 2022 Nov;46(11):1939-1947
pubmed: 35986215
Circ Res. 2016 May 27;118(11):1786-807
pubmed: 27230642
J Extracell Vesicles. 2012 Apr 16;1:
pubmed: 24009886
BMC Genomics. 2010 May 23;11:320
pubmed: 20492721
J Histochem Cytochem. 2002 Jul;50(7):877-84
pubmed: 12070266
Diabetes. 2018 Sep;67(9):1748-1760
pubmed: 29773555
Methods. 2015 Oct 1;87:31-45
pubmed: 25916618
Int J Obes (Lond). 2019 Nov;43(11):2200-2209
pubmed: 30622308
Mol Metab. 2021 Nov;53:101300
pubmed: 34303021
Obesity (Silver Spring). 2017 Jan;25(1):102-110
pubmed: 27883272
Front Physiol. 2020 Jan 29;10:1607
pubmed: 32063863
Gastroenterology. 2002 Sep;123(3):882-932
pubmed: 12198715
J Clin Endocrinol Metab. 2011 Nov;96(11):E1816-25
pubmed: 21849520
Mo Med. 2014 Jan-Feb;111(1):65-72
pubmed: 24645302
JCI Insight. 2021 Mar 8;6(5):
pubmed: 33539327
Nature. 2011 Jun 08;474(7353):649-53
pubmed: 21654750
Cancer Med. 2019 Mar;8(3):1110-1123
pubmed: 30623593
J Diabetes Res. 2020 Mar 19;2020:6894684
pubmed: 32258168
Obes Rev. 2019 May;20(5):701-712
pubmed: 30828970
Brain Commun. 2022 Oct 19;4(6):fcac262
pubmed: 36337342
J Med Genet. 1994 Nov;31(11):875-9
pubmed: 7853374
Int J Mol Sci. 2017 Jun 21;18(6):
pubmed: 28635626
Cell Metab. 2013 Dec 3;18(6):803-15
pubmed: 24268736
Mol Psychiatry. 2021 Dec;26(12):7417-7424
pubmed: 34385599
Anal Biochem. 2011 Jul 15;414(2):208-14
pubmed: 21447318
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2889-94
pubmed: 18287052
Protein Sci. 2018 Jan;27(1):233-244
pubmed: 28940711
Am J Physiol Cell Physiol. 2021 Mar 1;320(3):C375-C391
pubmed: 33356944
J Am Coll Cardiol. 2008 May 6;51(18):1775-83
pubmed: 18452784
Int J Endocrinol. 2018 Mar 12;2018:7351902
pubmed: 29721017
J Intern Med. 2007 Oct;262(4):408-14
pubmed: 17875176
J Clin Endocrinol Metab. 2010 Apr;95(4):1777-85
pubmed: 20130075
Mol Cell Biol. 2009 Aug;29(16):4467-83
pubmed: 19546236
Alzheimers Dement. 2021 Jan;17(1):49-60
pubmed: 32776690
J Diabetes Metab Disord. 2019 May 09;18(1):173-179
pubmed: 31275888
Biochem Biophys Res Commun. 2009 Dec 11;390(2):247-51
pubmed: 19800867
Cell Mol Life Sci. 2021 Mar;78(6):2987-3003
pubmed: 33206203
PLoS One. 2014 Sep 08;9(9):e103483
pubmed: 25198730
EBioMedicine. 2021 Jan;63:103192
pubmed: 33418508
Pharmacol Rev. 2012 Jul;64(3):676-705
pubmed: 22722893
Cancers (Basel). 2019 Jan 29;11(2):
pubmed: 30699970
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Apr;1866(4):158887
pubmed: 33454435
Am J Physiol. 1993 Jul;265(1 Pt 1):C234-43
pubmed: 8338133
Med Clin North Am. 2018 Jan;102(1):13-33
pubmed: 29156181
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Biochem Pharmacol. 2004 May 1;67(9):1667-75
pubmed: 15081866
Mol Carcinog. 2015 Jul;54(7):554-65
pubmed: 24347249
FEBS J. 2009 Apr;276(8):2348-58
pubmed: 19348006
J Diabetes Complications. 2016 Nov - Dec;30(8):1585-1592
pubmed: 27475263
Nutr Res. 2019 Jun;66:22-31
pubmed: 31051319
Mol Cell Endocrinol. 2016 Dec 5;437:213-223
pubmed: 27568466
Alzheimers Dement. 2015 Jun;11(6):600-7.e1
pubmed: 25130657
PLoS One. 2013 Jul 10;8(7):e68249
pubmed: 23874564
Mol Cell Biol. 2011 Feb;31(4):626-38
pubmed: 21135128
PLoS One. 2014 Jan 24;9(1):e86800
pubmed: 24475180
Cell Metab. 2012 May 2;15(5):739-51
pubmed: 22503562
PLoS One. 2009;4(3):e4699
pubmed: 19259271
Nutr Metab Cardiovasc Dis. 2015 Mar;25(3):295-304
pubmed: 25315666
Methods Enzymol. 2014;538:49-65
pubmed: 24529433
Eur Heart J. 2007 Apr;28(7):850-6
pubmed: 17403720
Alzheimers Dement (Amst). 2016 May 07;3:63-72
pubmed: 27408937
Alzheimers Dement. 2023 Nov;19(11):4952-4966
pubmed: 37071449
Neuropsychopharmacology. 2023 Jan;48(2):410-417
pubmed: 36100655

Auteurs

Shalini Mishra (S)

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Ashish Kumar (A)

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Susy Kim (S)

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Yixin Su (Y)

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Sangeeta Singh (S)

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Mitu Sharma (M)

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Sameh Almousa (S)

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Hilal A Rather (HA)

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Heetanshi Jain (H)

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Jingyun Lee (J)

Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina 27157, United States.

Cristina M Furdui (CM)

Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina 27157, United States.
Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Sarfaraz Ahmad (S)

Laboratory of Translational Hypertension, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Carlos M Ferrario (CM)

Laboratory of Translational Hypertension, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Henry A Punzi (HA)

Punzi Medical Center, Punzi Institute of Medicine, Carrollton, Texas 75006, United States.
UT Southwestern Medical Center, Dallas, Texas, 75390, United States.

Chia-Chi Chuang (CC)

Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Martin Wabitsch (M)

Department of Pediatrics and Adolescent Medicine, Center for Rare Endocrine Diseases, Ulm University Medical Centre, Ulm 89069, Germany.

Stephen B Kritchevsky (SB)

Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Thomas C Register (TC)

Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Gagan Deep (G)

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina 27157, United States.
Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH