Macular Neovascularization in a Case of Late-Onset Retinal Degeneration Treated with Aflibercept.

To describe the outcomes from treatment of macular neovascularization (MNV) in a eye affected by Late Onset Retinal Degeneration (L-ORD). A 72-year-old female patient presented with a history of decreased vision since several years. The patient was previously diagnosed with age-related macular degeneration and treated with anti-VEGFs. Clinical examination of the retina and ultra-widefield color fundus photographs showed extensive atrophy in both eyes. The left eye (OS) showed macular neovascularization (MNV) on fluorescein angiography (FA), subretinal fluid (SRF) on optical coherence tomography (OCT), and correspondent hemorrhages on the color fundus photography. Aflibercept anti-vascular endothelial factor treatment was used to treat the MNV in OS. We report a case of genetically confirmed L-ORD (heterozygous pathogenic mutation p.Ser163Arg in one C1QTN5 allele) with advanced degeneration of the retina complicated by MNV, which responded well to treatment with a single aflibercept injection.