Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits.
Autoresuscitation
Cardiac and respiratory coupling
Gasping
Hypotension
Olivocerebellar pathways
Ventral medulla
Journal
Journal of neuropathology and experimental neurology
ISSN: 1554-6578
Titre abrégé: J Neuropathol Exp Neurol
Pays: England
ID NLM: 2985192R
Informations de publication
Date de publication:
25 05 2023
25 05 2023
Historique:
pmc-release:
25
05
2024
medline:
26
5
2023
pubmed:
25
5
2023
entrez:
25
5
2023
Statut:
ppublish
Résumé
The sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality in the United States, is typically associated with a sleep period. Previously, we showed evidence of serotonergic abnormalities in the medulla (e.g. altered serotonin (5-HT)1A receptor binding), in SIDS cases. In rodents, 5-HT2A/C receptor signaling contributes to arousal and autoresuscitation, protecting brain oxygen status during sleep. Nonetheless, the role of 5-HT2A/C receptors in the pathophysiology of SIDS is unclear. We hypothesize that in SIDS, 5-HT2A/C receptor binding is altered in medullary nuclei that are key for arousal and autoresuscitation. Here, we report altered 5-HT2A/C binding in several key medullary nuclei in SIDS cases (n = 58) compared to controls (n = 12). In some nuclei the reduced 5-HT2A/C and 5-HT1A binding overlapped, suggesting abnormal 5-HT receptor interactions. The data presented here (Part 1) suggest that a subset of SIDS is due in part to abnormal 5-HT2A/C and 5-HT1A signaling across multiple medullary nuclei vital for arousal and autoresuscitation. In Part II to follow, we highlight 8 medullary subnetworks with altered 5-HT receptor binding in SIDS. We propose the existence of an integrative brainstem network that fails to facilitate arousal and/or autoresuscitation in SIDS cases.
Identifiants
pubmed: 37226597
pii: 7177600
doi: 10.1093/jnen/nlad030
pmc: PMC10209647
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
467-482Subventions
Organisme : NICHD NIH HHS
ID : P01 HD036379
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : NICHD NIH HHS
ID : R01HD090064
Pays : United States
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of American Association of Neuropathologists, Inc. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Références
J Physiol. 2000 May 1;524 Pt 3:833-51
pubmed: 10790162
Life (Basel). 2021 Feb 26;11(3):
pubmed: 33652660
Brain Res Bull. 1984 Jan;12(1):105-13
pubmed: 6201239
Exp Neurol. 2020 Apr;326:113165
pubmed: 31887304
Respir Physiol Neurobiol. 2013 Apr 1;186(2):214-20
pubmed: 23454177
Am J Respir Crit Care Med. 2003 Feb 15;167(4):563-9
pubmed: 12406845
J Neurophysiol. 2021 May 1;125(5):1543-1551
pubmed: 33760672
J Neurosci. 2009 Aug 19;29(33):10341-9
pubmed: 19692608
J Comp Neurol. 1995 Jan 2;351(1):5-26
pubmed: 7534775
Pediatrics. 1998 Feb;101(2):285-8
pubmed: 9445505
EMBO Rep. 2008 Feb;9(2):114-8
pubmed: 18246101
Front Neurol. 2018 Sep 10;9:752
pubmed: 30250449
Respir Physiol Neurobiol. 2002 Jun;130(3):253-63
pubmed: 12093622
J Neurophysiol. 2010 Aug;104(2):685-94
pubmed: 20484535
Neurosci Lett. 1984 Jan 27;44(1):105-11
pubmed: 6717845
Sleep Med Rev. 2002 Feb;6(1):55-69
pubmed: 12531142
J Appl Physiol (1985). 2016 Mar 1;120(5):514-25
pubmed: 26702023
J Appl Physiol (1985). 2001 Apr;90(4):1247-57
pubmed: 11247921
Brain Res Bull. 1983 Feb;10(2):171-284
pubmed: 6839182
J Neuropathol Exp Neurol. 2017 Oct 1;76(10):864-873
pubmed: 28922849
J Appl Physiol (1985). 2004 Dec;97(6):2303-9
pubmed: 15322068
Am J Respir Crit Care Med. 2003 Dec 1;168(11):1298-303
pubmed: 12917226
J Appl Physiol (1985). 2004 Dec;97(6):2236-47
pubmed: 15322066
Pulm Pharmacol Ther. 2015 Dec;35:105-10
pubmed: 26549786
BMJ Open. 2013 May 28;3(5):
pubmed: 23793691
J Physiol. 2005 Jul 15;566(Pt 2):543-57
pubmed: 15878953
J Neuropathol Exp Neurol. 2019 Sep 1;78(9):765-779
pubmed: 31397480
Pediatrics. 2017 Jul;140(1):
pubmed: 28759397
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):133-43
pubmed: 19481178
Pediatrics. 2022 Jul 1;150(1):
pubmed: 35921639
Sleep Med Rev. 2011 Aug;15(4):269-81
pubmed: 21459634
J Appl Physiol (1985). 2010 May;108(5):1425-32
pubmed: 20133432
J Cell Sci. 2012 May 15;125(Pt 10):2486-99
pubmed: 22357950
PLoS One. 2021 Sep 10;16(9):e0256197
pubmed: 34506527
Neurology. 2014 Sep 16;83(12):1104-11
pubmed: 25107878
Curr Opin Neurobiol. 2017 Jun;44:186-192
pubmed: 28577468
J Neurol Sci. 2022 Mar 15;434:120091
pubmed: 34979371
J Appl Physiol (1985). 2017 Oct 1;123(4):825-834
pubmed: 28775068
Cell Rep. 2014 Dec 24;9(6):2152-65
pubmed: 25497093
Adv Neurol. 1986;43:407-68
pubmed: 2418648
Am J Physiol Regul Integr Comp Physiol. 2018 Feb 1;314(2):R313-R321
pubmed: 29046318
Respir Physiol Neurobiol. 2005 Nov 15;149(1-3):257-71
pubmed: 15876558
Biol Neonate. 1994;65(3-4):194-7
pubmed: 8038282
Auton Neurosci. 2007 Mar 30;132(1-2):81-102
pubmed: 17236817
Rev Neurosci. 2016 Jan;27(1):1-25
pubmed: 26418645
Dialogues Clin Neurosci. 2010;12(4):471-87
pubmed: 21319493
Int J Mol Sci. 2021 Feb 15;22(4):
pubmed: 33672070
J Appl Physiol (1985). 2009 Jun;106(6):1785-92
pubmed: 19213929
Biol Neonate. 1994;65(3-4):189-93
pubmed: 7913630
Acta Neuropathol. 2004 Oct;108(4):309-18
pubmed: 15300449
J Physiol Pharmacol. 2002 Sep;53(3):395-407
pubmed: 12369737
Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):222-32
pubmed: 18595785
J Neurosci. 2005 Sep 7;25(36):8322-32
pubmed: 16148240
Int Rev Neurobiol. 2007;77:31-56
pubmed: 17178471
J Appl Physiol (1985). 2006 Aug;101(2):549-55
pubmed: 16690795
Neurosci Lett. 1992 Aug 31;143(1-2):91-5
pubmed: 1436685
Forensic Sci Med Pathol. 2019 Dec;15(4):622-628
pubmed: 31502215
Acta Physiol Scand Suppl. 1964;:SUPPL 232:1-55
pubmed: 14229500
Physiol Res. 2011;60(1):15-25
pubmed: 20945968
Acta Paediatr. 2021 Jan;110(1):174-183
pubmed: 32304589
N Engl J Med. 2022 May 19;386(20):1873-1875
pubmed: 35551514
Front Neurosci. 2018 Aug 07;12:535
pubmed: 30131671
J Biol Chem. 2002 May 3;277(18):15482-5
pubmed: 11854302
Auton Neurosci. 2003 May 30;105(2):131-44
pubmed: 12798209
Cells. 2021 Jul 27;10(8):
pubmed: 34440670
Ann N Y Acad Sci. 1990;600:9-34; discussion 34-5
pubmed: 2252340
J Neurosci. 2009 Mar 25;29(12):3720-37
pubmed: 19321769
J Appl Physiol (1985). 2013 Jun 15;114(12):1668-76
pubmed: 23558391
Exp Brain Res. 1995;106(1):79-92
pubmed: 8542980
Neuroscience. 2010 Jan 13;165(1):61-78
pubmed: 19800944
Physiol Rev. 1992 Jan;72(1):165-229
pubmed: 1731370
Neuroscience. 1997 Dec;81(3):873-85
pubmed: 9316035
Auton Neurosci. 2009 May 11;147(1-2):48-55
pubmed: 19213611
J Neuropathol Exp Neurol. 2000 May;59(5):377-84
pubmed: 10888367
Front Neurol. 2021 Mar 10;12:636668
pubmed: 33776893
J Physiol. 2001 Apr 15;532(Pt 2):467-81
pubmed: 11306665
Auton Neurosci. 2001 Jun 20;89(1-2):110-24
pubmed: 11474639
Front Physiol. 2018 Jul 10;9:832
pubmed: 30050449
J Neurosci. 2012 May 2;32(18):6295-303
pubmed: 22553035
Brain Res. 1981 Oct 5;222(1):129-33
pubmed: 6170384
Trends Neurosci. 2019 Nov;42(11):807-824
pubmed: 31635852
J Epidemiol Community Health. 1992 Feb;46(1):33-7
pubmed: 1573357
Elife. 2018 Oct 23;7:
pubmed: 30350782
Prog Neurobiol. 1994 Oct;44(2):197-219
pubmed: 7831477
J Appl Physiol (1985). 2005 Apr;98(4):1234-42
pubmed: 15579571
J Neurosci. 2005 Dec 7;25(49):11231-8
pubmed: 16339018
Pediatrics. 2004 Jul;114(1):234-8
pubmed: 15231934
Brain Commun. 2021 Jul 09;3(3):fcab149
pubmed: 34396109
Pharmacol Res. 2019 Feb;140:100-114
pubmed: 29953943
Acta Neuropathol. 2009 Mar;117(3):257-65
pubmed: 19052756
J Neuropathol Exp Neurol. 2001 Mar;60(3):228-47
pubmed: 11245208
Neurology. 2017 Mar 21;88(12):1187-1196
pubmed: 28202704
Chronobiol Int. 2006;23(5):935-61
pubmed: 17050210
J Neurosci. 2011 Feb 9;31(6):1981-90
pubmed: 21307236
Neuropharmacology. 2013 Jul;70:19-26
pubmed: 23321054
JAMA. 2010 Feb 3;303(5):430-7
pubmed: 20124538
J Appl Physiol (1985). 2008 Jun;104(6):1801-8
pubmed: 18420721
EBioMedicine. 2022 Jun;80:104041
pubmed: 35533499
Paediatr Respir Rev. 2014 Dec;15(4):293-300
pubmed: 25304427
J Neurosci. 2008 Mar 5;28(10):2495-505
pubmed: 18322094
Pflugers Arch. 2011 Sep;462(3):407-18
pubmed: 21739157
J Pediatr. 1989 Apr;114(4 Pt 1):561-7
pubmed: 2926568
Neurosci Biobehav Rev. 2017 Mar;74(Pt B):366-375
pubmed: 27208411
Science. 1991 Nov 1;254(5032):726-9
pubmed: 1683005
Nat Rev Neurosci. 2019 Jul;20(7):397-424
pubmed: 30948838
ACS Chem Neurosci. 2013 Jan 16;4(1):48-63
pubmed: 23336044
J Neurocytol. 2002 Sep-Nov;31(8-9):667-79
pubmed: 14501206
Neuropediatrics. 2002 Jun;33(3):142-9
pubmed: 12200744
Science. 2011 Jul 29;333(6042):637-42
pubmed: 21798952
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):59-68
pubmed: 19712903
Dev Neurosci. 1995;17(4):236-45
pubmed: 8575343
J Matern Fetal Neonatal Med. 2022 Dec;35(26):10444-10450
pubmed: 36195459
Front Physiol. 2014 Jun 25;5:238
pubmed: 25009507
Front Behav Neurosci. 2014 Sep 12;8:318
pubmed: 25309369
J Appl Physiol (1985). 2004 May;96(5):1815-24
pubmed: 14672965
Pharmacol Rev. 2012 Apr;64(2):359-88
pubmed: 22407614
Virchows Arch. 2006 Dec;449(6):697-706
pubmed: 17091255
Front Neurosci. 2013 Mar 27;7:36
pubmed: 23543912
ACS Omega. 2017 Aug 31;2(8):4779-4789
pubmed: 28920103
J Neurophysiol. 2015 Jul;114(1):233-43
pubmed: 25925320
Am J Respir Crit Care Med. 2005 Nov 15;172(10):1322-30
pubmed: 16100007
Respir Physiol Neurobiol. 2010 Nov 30;174(1-2):76-88
pubmed: 20801236
Cell Mol Neurobiol. 2012 Jul;32(5):695-708
pubmed: 22484834
J Comp Neurol. 1995 Dec 25;363(4):563-580
pubmed: 8847418
J Appl Physiol (1985). 2004 Feb;96(2):693-703
pubmed: 14565965
Cell Metab. 2018 Oct 2;28(4):619-630.e5
pubmed: 30146485
J Neurosci. 2009 May 6;29(18):5806-19
pubmed: 19420248
J Epidemiol Community Health. 1989 Jun;43(2):133-9
pubmed: 2592901
Biomedicines. 2021 Oct 26;9(11):
pubmed: 34829763
Brain Res Bull. 2018 Mar;137:319-328
pubmed: 29331576
Brain Connect. 2016 Apr;6(3):187-200
pubmed: 26530629
J Neurosci Res. 2002 Jan 1;67(1):69-85
pubmed: 11754082
J Appl Physiol (1985). 2013 Dec;115(12):1733-41
pubmed: 24136109
Pediatr Dev Pathol. 2018 Nov-Dec;21(6):515-521
pubmed: 29759045
J Comp Neurol. 1988 Jul 8;273(2):224-40
pubmed: 2901439
Am J Physiol Regul Integr Comp Physiol. 2003 Mar;284(3):R782-91
pubmed: 12611395
Naunyn Schmiedebergs Arch Pharmacol. 1994 May;349(5):447-54
pubmed: 8065458
Respir Physiol Neurobiol. 2010 Oct 31;173(3):256-63
pubmed: 20226279
J Neuropathol Exp Neurol. 2011 Sep;70(9):799-810
pubmed: 21865888
Exp Physiol. 2016 Jul 1;101(7):946-61
pubmed: 27121960