Pathogenesis of endometrium-related diseases based on genomic alterations in normal uterine endometrium.
3D structure
cancer-associated gene mutation
endometriosis
endometrium
rhizome
Journal
The journal of obstetrics and gynaecology research
ISSN: 1447-0756
Titre abrégé: J Obstet Gynaecol Res
Pays: Australia
ID NLM: 9612761
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
05
05
2023
accepted:
08
05
2023
medline:
3
8
2023
pubmed:
25
5
2023
entrez:
25
5
2023
Statut:
ppublish
Résumé
The human endometrium is a dynamically remodeling tissue that undergoes more than 400 cycles of regeneration, differentiation, shedding, and rapid healing during a woman's reproductive years. The endometrium is also the origin of various gynecologic diseases, such as endometriosis, adenomyosis, and uterine corpus cancer. Cancer-associated gene mutations are detected in endometriosis, adenomyosis, and normal endometrium. Some reports have demonstrated that the accumulation of genomic alterations is a critical carcinogenic mechanism in the progression from normal endometrium to ovarian clear cell carcinoma via endometriosis. In this review, we discuss the clinical importance of genomic alterations in the normal endometrium, contributing to the elucidation of the pathogenesis of endometrium-related diseases.
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2023-2030Informations de copyright
© 2023 Japan Society of Obstetrics and Gynecology.
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