FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice.
ILEI/FAM3C
inflammation
keratinocyte differentiation
psoriasis
uPA/PLAU
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
10 07 2023
10 07 2023
Historique:
revised:
06
05
2023
received:
17
08
2022
accepted:
08
05
2023
medline:
11
7
2023
pubmed:
25
5
2023
entrez:
25
5
2023
Statut:
ppublish
Résumé
FAM3C/ILEI is an important cytokine for tumor progression and metastasis. However, its involvement in inflammation remains elusive. Here, we show that ILEI protein is highly expressed in psoriatic lesions. Inducible keratinocyte-specific ILEI overexpression in mice (K5-ILEI
Identifiants
pubmed: 37226685
doi: 10.15252/emmm.202216758
pmc: PMC10331587
doi:
Substances chimiques
Urokinase-Type Plasminogen Activator
EC 3.4.21.73
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e16758Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
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