Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2.
BMP
C2C12 myoblasts
KCP (kielim/chordin-like protein)
osteoarthritis
osteoblasts
Journal
FEBS open bio
ISSN: 2211-5463
Titre abrégé: FEBS Open Bio
Pays: England
ID NLM: 101580716
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
11
05
2023
received:
22
03
2023
accepted:
24
05
2023
medline:
4
7
2023
pubmed:
25
5
2023
entrez:
25
5
2023
Statut:
ppublish
Résumé
Bone morphogenetic proteins (BMPs) play a key role in embryonic differentiation for osteoblast and bone formation. Kielin/chordin-like protein (Kcp) is known to enhance the effects of BMP signaling. Here, we present ALP activity, gene expression, and calcification data demonstrating that Kcp affects the differentiation of C2C12 myoblasts into osteoblasts. We report that the presence of Kcp enhances the ability of BMP-2 to induce the differentiation of C2C12 myoblasts into osteoblasts. Additionally, BMP-2-mediated stimulation of phosphorylated Smad1/5 was apparently enhanced in the presence of Kcp. The present findings may contribute to progression toward the clinical use of BMPs for treatment of bone fracture, osteoarthritis, and other similar conditions.
Identifiants
pubmed: 37226930
doi: 10.1002/2211-5463.13652
pmc: PMC10315795
doi:
Substances chimiques
chordin
93586-27-7
Bone Morphogenetic Proteins
0
Glycoproteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1357-1364Informations de copyright
© 2023 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
Références
Exp Mol Med. 2009 Feb 28;41(2):116-25
pubmed: 19287192
Science. 1996 Jan 19;271(5247):360-2
pubmed: 8553073
Hum Reprod Update. 2014 Nov-Dec;20(6):869-83
pubmed: 24980253
Int J Biol Sci. 2012;8(2):272-88
pubmed: 22298955
Leukemia. 2011 Sep;25(9):1379-88
pubmed: 21566654
Nat Med. 2005 Apr;11(4):387-93
pubmed: 15793581
Mol Cell Biol. 2006 Jun;26(12):4577-85
pubmed: 16738323
Gene. 2002 Apr 3;287(1-2):39-47
pubmed: 11992721
J Biol Chem. 2006 Aug 11;281(32):23246-53
pubmed: 16754660
J Diabetes Res. 2021 Jun 23;2021:6707464
pubmed: 34258293
J Mol Endocrinol. 2018 Oct 1;:
pubmed: 30400042
Biochim Biophys Acta Gen Subj. 2021 Feb;1865(2):129799
pubmed: 33232799