Individualized targeting is warranted in subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression: A tractography analysis.
deep brain stimulation
segmentation
subcallosal cingulate gyrus
tractography
treatment-resistant depression
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 08 2023
01 08 2023
Historique:
revised:
27
04
2023
received:
08
08
2022
accepted:
01
05
2023
medline:
5
7
2023
pubmed:
25
5
2023
entrez:
25
5
2023
Statut:
ppublish
Résumé
Subcallosal cingulate gyrus (SCG) is a target of deep brain stimulation (DBS) for treatment-resistant depression. However, previous randomized controlled trials report that approximately 42% of patients are responders to this therapy of last resort, and suboptimal targeting of SCG is a potential underlying factor to this unsatisfactory efficacy. Tractography has been proposed as a supplementary method to enhance targeting strategy. We performed a connectivity-based segmentation in the SCG region via probabilistic tractography in 100 healthy volunteers from the Human Connectome Project. The SCG voxels with maximum connectivity to brain regions implicated in depression, including Brodmann Area 10 (BA10), cingulate cortex, thalamus, and nucleus accumbens were identified, and the conjunctions were deemed as tractography-based targets. We then performed deterministic tractography using these targets in additional 100 volunteers to calculate streamline counts compassing to relevant brain regions and fibers. We also evaluated the intra- and inter-subject variance using test-retest dataset. Two tractography-based targets were identified. Tractography-based target-1 had the highest streamline counts to right BA10 and bilateral cingulate cortex, while tractography-based target-2 had the highest streamline counts to bilateral nucleus accumbens and uncinate fasciculus. The mean linear distance from individual tractography-based target to anatomy-based target was 3.2 ± 1.8 mm and 2.5 ± 1.4 mm in left and right hemispheres. The mean ± SD of targets between intra- and inter-subjects were 2.2 ± 1.2 and 2.9 ± 1.4 in left hemisphere, and 2.3 ± 1.4 and 3.1 ± 1.7 in right hemisphere, respectively. Individual heterogeneity as well as inherent variability from diffusion imaging should be taken into account during SCG-DBS target planning procedure.
Identifiants
pubmed: 37227015
doi: 10.1002/hbm.26339
pmc: PMC10318244
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4200-4210Subventions
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Informations de copyright
© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Neurosurgery. 2016 Sep;79(3):465-72
pubmed: 27327267
Lancet Psychiatry. 2017 Nov;4(11):839-849
pubmed: 28988904
Hum Brain Mapp. 2019 Feb 15;40(3):889-903
pubmed: 30311317
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Med Image Anal. 2019 Feb;52:56-67
pubmed: 30471463
Mol Psychiatry. 2018 Apr;23(4):843-849
pubmed: 28397839
Brain Stimul. 2020 Jul - Aug;13(4):1094-1101
pubmed: 32417668
J Mol Neurosci. 2008;34(1):51-61
pubmed: 18157658
Hum Brain Mapp. 2023 Aug 1;44(11):4200-4210
pubmed: 37227015
Am J Psychiatry. 2019 Nov 1;176(11):949-956
pubmed: 31581800
Mol Psychiatry. 2018 May;23(5):1094-1112
pubmed: 29483673
Brain Stimul. 2021 Sep-Oct;14(5):1226-1233
pubmed: 34400379
Biol Psychiatry. 2000 Oct 15;48(8):830-43
pubmed: 11063978
Neuroimage. 2019 Nov 1;201:116026
pubmed: 31326569
Biol Psychiatry. 2014 Dec 15;76(12):963-9
pubmed: 24832866
AJNR Am J Neuroradiol. 2012 Jun;33(6):1072-80
pubmed: 22300931
Neuroimage. 2017 Jan 1;144(Pt A):83-91
pubmed: 27646126
Stereotact Funct Neurosurg. 2012;90(4):225-32
pubmed: 22699718
NMR Biomed. 2015 Apr;28(4):423-31
pubmed: 25703088
J Neurosurg. 2009 Dec;111(6):1209-15
pubmed: 19480538
Biol Psychiatry. 2009 Feb 15;65(4):276-82
pubmed: 19013554
Magn Reson Med. 2017 Feb;77(2):603-612
pubmed: 26843524
Biol Psychiatry. 2011 Feb 15;69(4):301-8
pubmed: 21145043
Neuroimage. 2013 Oct 15;80:105-24
pubmed: 23668970
J Neurosurg. 2012 Feb;116(2):315-22
pubmed: 22098195
J Affect Disord. 2018 Feb;227:521-529
pubmed: 29161674
Neuroimage. 2013 Oct 15;80:62-79
pubmed: 23684880
Neuroimage. 2010 Aug 1;52(1):69-85
pubmed: 20398772
Neuron. 2005 Mar 3;45(5):651-60
pubmed: 15748841
Neuroimage. 2022 Jul 1;254:119138
pubmed: 35339687
Biol Psychiatry. 2010 Jan 15;67(2):110-6
pubmed: 19914605
IEEE Trans Med Imaging. 2010 Sep;29(9):1626-35
pubmed: 20304721
Cereb Cortex. 2016 Aug;26(8):3508-26
pubmed: 27230218
Am J Psychiatry. 2011 May;168(5):502-10
pubmed: 21285143
Biol Psychiatry. 2008 Sep 15;64(6):461-7
pubmed: 18639234
Hum Brain Mapp. 2019 Jul;40(10):3041-3057
pubmed: 30875144
Neuroimage. 2008 Jan 1;39(1):336-47
pubmed: 17931890