Case report of Usutu virus infection in an immunocompromised patient in Italy, 2022.
Arbovirus
Endemic
Flavivirus
Human case
Italy
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
01
03
2023
accepted:
03
05
2023
revised:
26
04
2023
medline:
7
8
2023
pubmed:
25
5
2023
entrez:
25
5
2023
Statut:
ppublish
Résumé
Usutu virus (USUV) is an arthropod-borne flavivirus emerged in Africa in 1950s and in Eruope in 1990s causing a massive number of birds' deaths. The role of USUV as human pathogen has been only recently hypothesized and cases of USUV infection in humans remain limited and often related to immunocompromised subjects. Herein, we report a case of USUV meningoencephalitis infection in an immunocompromised patient with no history of previous flavivirus infection. The infection due to USUV evolved rapidly since hospital admission thus resulting fatal in few days after symptoms onset and, although not proven, a suspected bacteria co-infection has been hypothesized. Based on these findings, we suggested that when USUV meningoencephalitis is suspected in countries endemic, careful attention should be applied to neurological syndromes during summer months especially among immunocompromised patients.
Identifiants
pubmed: 37227671
doi: 10.1007/s13365-023-01148-w
pii: 10.1007/s13365-023-01148-w
pmc: PMC10211289
doi:
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
364-366Informations de copyright
© 2023. The Author(s) under exclusive licence to The Journal of NeuroVirology, Inc.
Références
Ashraf U, Ye J, Ruan X, Wan S et al (2015) Usutu virus: an emerging flavivirus in Europe. Viruses 7:219–238
doi: 10.3390/v7010219
pubmed: 25606971
pmcid: 4306835
Cavrini F, Della Pepa ME, Gaibani P et al (2011) A rapid and specific real-time RT-PCR assay to identify Usutu virus in human plasma, serum, and cerebrospinal fluid. J Clin Virol 50:221–223
doi: 10.1016/j.jcv.2010.11.008
pubmed: 21156352
Clé M, Beck C, Salinas S et al (2019) Usutu virus: a new threat? Epidemiol Infect 147:e232
doi: 10.1017/S0950268819001213
pubmed: 31364580
pmcid: 6625183
Gaibani P, Pierro A, Alicino R et al (2012) Detection of Usutu-virus-specific IgG in blood donors from northern Italy. Vector Borne Zoonotic Dis 1:431–433
doi: 10.1089/vbz.2011.0813
Gaibani P, Rossini G (2017) An overview of Usutu virus. Microbes Infect 19:382–387
doi: 10.1016/j.micinf.2017.05.003
pubmed: 28602915
Pacenti M, Sinigaglia A, Martello T et al (2019) Clinical and virological findings in patients with Usutu virus infection, northern Italy, 2018. Euro Surveill 24:1900180
doi: 10.2807/1560-7917.ES.2019.24.47.1900180
pubmed: 31771697
pmcid: 6885746
Roesch F, Fajardo A, Moratorio G et al (2019) Usutu virus: an arbovirus on the rise. Viruses 11:640
doi: 10.3390/v11070640
pubmed: 31336826
pmcid: 6669749
Vilibic-Cavlek T, Petrovic T, Savic V et al (2020) Epidemiology of Usutu virus: the European scenario. Pathogens 9:699
doi: 10.3390/pathogens9090699
pubmed: 32858963
pmcid: 7560012