Plasma virome dynamics in chronic hepatitis B virus infected patients.

anellovirus blood hepatitis B virus metagenomic pegivirus plasma virome

Journal

Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977

Informations de publication

Date de publication:
2023
Historique:
received: 23 02 2023
accepted: 19 04 2023
medline: 25 5 2023
pubmed: 25 5 2023
entrez: 25 5 2023
Statut: epublish

Résumé

The virome remains an understudied domain of the human microbiome. The role of commensal viruses on the outcome of infections with known pathogens is not well characterized. In this study we aimed to characterize the longitudinal plasma virome dynamics in chronic hepatitis B virus (HBV) infected patients. Eighty-five longitudinal plasma samples were collected from 12 chronic HBV infected individuals that were classified in the four stages of HBV infection. The virome was characterized with an optimized viral extraction protocol and deep-sequenced on a NextSeq 2500 platform. The plasma virome was primarily composed of members of the

Identifiants

pubmed: 37228370
doi: 10.3389/fmicb.2023.1172574
pmc: PMC10203228
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1172574

Informations de copyright

Copyright © 2023 Thijssen, Tacke, Van Espen, Cassiman, Naser Aldine, Nevens, Van Ranst, Matthijnssens and Pourkarim.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Marijn Thijssen (M)

Laboratory for Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.

Frank Tacke (F)

Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Lore Van Espen (L)

Laboratory of Viral Metagenomics, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.

David Cassiman (D)

Department of Gastroenterology and Hepatology, University Hospital Leuven, Leuven, Belgium.

Mahmoud Naser Aldine (M)

Laboratory for Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.

Frederik Nevens (F)

Department of Gastroenterology and Hepatology, University Hospital Leuven, Leuven, Belgium.

Marc Van Ranst (M)

Laboratory for Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.

Jelle Matthijnssens (J)

Laboratory of Viral Metagenomics, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.

Mahmoud Reza Pourkarim (MR)

Laboratory for Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Health Policy Research Centre, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.

Classifications MeSH