A Recombinant Parathyroid Hormone-Related Peptide Locally Applied in Osteoporotic Bone Defect.
bioactive scaffold
bone remodeling
osteoblasts
osteoclasts
osteoporotic bone defect
parathyroid hormone-related peptide
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
20
03
2023
received:
24
01
2023
medline:
7
8
2023
pubmed:
25
5
2023
entrez:
25
5
2023
Statut:
ppublish
Résumé
The local application of drug-loaded bioactive scaffold materials is one of the important directions to solve the clinical problem of osteoporotic (OP) bone defects. This study retains the advantages of drug loading and mechanical properties of natural 3D bioactive scaffolds. The scaffolds are functionally modified through chemical and self-assembly approaches with application of polydopamine (PDA) nanoparticles and parathyroid hormone-related peptide-1 (PTHrP-1) for efficient local drug loading. This study investigates the effects of the novel bioactive scaffolds on ossification, osteoclastogenesis, and macrophage polarization. This work elucidates the effects of the scaffolds in regulating osteoclastic activity and new bone formation in vitro. Further studies on the establishment and repair of OP bone defects in small animals are conducted, and the potential of natural bioactive porous scaffold materials to promote the repair of OP bone defects is initially verified. The preparation of safe and economical anti-OP bone repair material provides a theoretical basis for clinical translational applications.
Identifiants
pubmed: 37229774
doi: 10.1002/advs.202300516
pmc: PMC10401080
doi:
Substances chimiques
Parathyroid Hormone-Related Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300516Subventions
Organisme : National Natural Science Foundation of China
ID : 81871752
Organisme : National Natural Science Foundation of China
ID : 81870162
Organisme : Key Research and Development Program of Hubei Province
ID : 2022BCA052
Organisme : Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University
ID : ZNJC202014
Informations de copyright
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Références
J Clin Med. 2022 Dec 16;11(24):
pubmed: 36556093
Biomaterials. 2021 Jul;274:120841
pubmed: 33984633
ACS Appl Mater Interfaces. 2020 Jun 24;12(25):27889-27904
pubmed: 32130854
ACS Appl Mater Interfaces. 2018 Dec 19;10(50):44080-44091
pubmed: 30475576
ACS Appl Mater Interfaces. 2021 Nov 3;13(43):50836-50850
pubmed: 34689546
J Biomed Mater Res A. 2020 Jan;108(1):166-177
pubmed: 31581365
Sci Adv. 2021 Dec 10;7(50):eabj1083
pubmed: 34878837
Pharmacol Res. 2023 Jan;187:106635
pubmed: 36581167
ACS Nano. 2019 Aug 27;13(8):9595-9606
pubmed: 31381856
Bioact Mater. 2020 Aug 11;6(1):91-105
pubmed: 32817917
Bioact Mater. 2021 Sep 22;10:236-246
pubmed: 34901542
Chem Soc Rev. 2011 Jul;40(7):4244-58
pubmed: 21603689
ACS Nano. 2019 Aug 27;13(8):8537-8565
pubmed: 31369230
Pharmacol Ther. 2022 Sep;237:108168
pubmed: 35283172
Small. 2022 Sep;18(38):e2202691
pubmed: 35986434
Tissue Eng Regen Med. 2021 Dec;18(6):1021-1033
pubmed: 34427911
Biomaterials. 2012 Jul;33(20):5076-84
pubmed: 22504017
Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:1246-1262
pubmed: 28575964
Mater Today Bio. 2022 Oct 10;17:100458
pubmed: 36278143
Biomaterials. 2019 Jan;190-191:97-110
pubmed: 30415019
Ann Intern Med. 2023 Feb;176(2):224-238
pubmed: 36592456
Adv Mater. 2022 Sep;34(36):e2202044
pubmed: 35785450
Adv Sci (Weinh). 2022 Apr;9(11):e2103820
pubmed: 35128831
Acta Biomater. 2023 Feb;157:609-624
pubmed: 36526242
J Adv Res. 2023 Jan 8;:
pubmed: 36632888
Adv Sci (Weinh). 2022 May;9(13):e2103317
pubmed: 35266637
Biomaterials. 2021 Feb;269:120534
pubmed: 33243425
Adv Sci (Weinh). 2023 Aug;10(22):e2300516
pubmed: 37229774
Asian J Pharm Sci. 2023 Jan;18(1):100774
pubmed: 36751654
Bone. 2022 Jul;160:116417
pubmed: 35398589
Cell Biosci. 2022 May 26;12(1):70
pubmed: 35619122
J Endod. 2016 Aug;42(8):1226-32
pubmed: 27377439
Sci Rep. 2016 Jun 09;6:27521
pubmed: 27279629
Carbohydr Polym. 2023 Feb 15;302:120349
pubmed: 36604043
Biofabrication. 2020 Jun 12;12(3):035020
pubmed: 32369796
Chem Soc Rev. 2021 Oct 18;50(20):11668-11683
pubmed: 34477190
Adv Sci (Weinh). 2022 Nov 17;:e2204234
pubmed: 36394157
Bone Joint Res. 2020 Jul 31;9(7):368-385
pubmed: 32793332
Mater Horiz. 2021 Jun 1;8(6):1618-1633
pubmed: 34846495
Bioact Mater. 2021 Aug 20;9:446-460
pubmed: 34820582
Biochem Pharmacol. 2021 Oct;192:114669
pubmed: 34224692
Small. 2020 Feb;16(6):e1905876
pubmed: 31962381
Bioact Mater. 2020 Aug 29;6(2):346-360
pubmed: 32954053