Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population.
Alzheimer’s disease
Arterial spin labeling (ASL)
cerebral blood flow (CBF)
twin analysis
white matter hyperintensities
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
medline:
23
10
2023
pubmed:
26
5
2023
entrez:
26
5
2023
Statut:
ppublish
Résumé
Aging-related cognitive decline can be accelerated by a combination of genetic factors, cardiovascular and cerebrovascular dysfunction, and amyloid-β burden. Whereas cerebral blood flow (CBF) has been studied as a potential early biomarker of cognitive decline, its normal variability in healthy elderly is less known. In this study, we investigated the contribution of genetic, vascular, and amyloid-β components of CBF in a cognitively unimpaired (CU) population of monozygotic older twins. We included 134 participants who underwent arterial spin labeling (ASL) MRI and [
Identifiants
pubmed: 37231665
doi: 10.1177/0271678X231178993
pmc: PMC10581242
doi:
Substances chimiques
Amyloid beta-Peptides
0
Amyloid
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1726-1736Subventions
Organisme : Department of Health
Pays : United Kingdom
Déclaration de conflit d'intérêts
Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: BP, LL, DVG, EC, SI, JT, QD, MS, EJCdG, EvG, MK, JP, AdB, and HM have no conflicts of interest related to the current work.
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