Fungal Drug Response and Antimicrobial Resistance.
antifungal drugs
antifungal resistance
multidrug efflux
pathogenic fungi
pleiotropic drug response
Journal
Journal of fungi (Basel, Switzerland)
ISSN: 2309-608X
Titre abrégé: J Fungi (Basel)
Pays: Switzerland
ID NLM: 101671827
Informations de publication
Date de publication:
12 May 2023
12 May 2023
Historique:
received:
23
03
2023
revised:
27
04
2023
accepted:
12
05
2023
medline:
26
5
2023
pubmed:
26
5
2023
entrez:
26
5
2023
Statut:
epublish
Résumé
Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals. The limited number of antifungal agents and the emergence of resistance have led to a critical need to understand the mechanisms of antifungal drug resistance. This review provides an overview of the importance of antifungal resistance, the classes of antifungal agents, and their mode of action. It highlights the molecular mechanisms of antifungal drug resistance, including alterations in drug modification, activation, and availability. In addition, the review discusses the response to drugs via the regulation of multidrug efflux systems and antifungal drug-target interactions. We emphasize the importance of understanding the molecular mechanisms of antifungal drug resistance to develop effective strategies to combat the emergence of resistance and highlight the need for continued research to identify new targets for antifungal drug development and explore alternative therapeutic options to overcome resistance. Overall, an understanding of antifungal drug resistance and its mechanisms will be indispensable for the field of antifungal drug development and clinical management of fungal infections.
Identifiants
pubmed: 37233275
pii: jof9050565
doi: 10.3390/jof9050565
pmc: PMC10219139
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : PID2019-104214RB-I00
Organisme : Agencia Valenciana de la Innovación
ID : INNEST/2021/266
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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