Bone Metabolite Profile Differs between Normal and Femur Head Necrosis (FHN/BCO)-Affected Broilers: Implications for Dysregulated Metabolic Cascades in FHN Pathophysiology.
bacterial chondronecrosis with osteomyelitis
broiler
femur head necrosis
metabolome
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
16 May 2023
16 May 2023
Historique:
received:
11
04
2023
revised:
28
04
2023
accepted:
30
04
2023
medline:
26
5
2023
pubmed:
26
5
2023
entrez:
26
5
2023
Statut:
epublish
Résumé
Femur head necrosis (FHN), also known as bacterial chondronecrosis with osteomyelitis (BCO), has remained an animal welfare and production concern for modern broilers regardless of efforts to select against it in primary breeder flocks. Characterized by the bacterial infection of weak bone, FHN has been found in birds without clinical lameness and remains only detectable via necropsy. This presents an opportunity to utilize untargeted metabolomics to elucidate potential non-invasive biomarkers and key causative pathways involved in FHN pathology. The current study used ultra-performance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-HRMS) and identified a total of 152 metabolites. Mean intensity differences at
Identifiants
pubmed: 37233703
pii: metabo13050662
doi: 10.3390/metabo13050662
pmc: PMC10223080
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Cobb-Vantress, Inc
ID : RAC
Références
Nat Biotechnol. 2012 Oct;30(10):918-20
pubmed: 23051804
Curr Protoc Bioinformatics. 2012 Mar;Chapter 14:Unit14.11
pubmed: 22389014
Osteoporos Int. 2011 May;22(5):1451-8
pubmed: 20577873
Poult Sci. 2021 Mar;100(3):100808
pubmed: 33518301
Nat Protoc. 2008;3(6):1101-8
pubmed: 18546601
Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361
pubmed: 27899662
Anal Chem. 2010 Apr 15;82(8):3212-21
pubmed: 20349993
Stem Cell Res Ther. 2022 Feb 22;13(1):77
pubmed: 35193674
J Physiol. 1929 Nov 25;68(3):213-37
pubmed: 16994064
Cells. 2021 Nov 15;10(11):
pubmed: 34831397
Biomark Insights. 2016 Apr 27;11:55-62
pubmed: 27147818
BMC Genomics. 2019 Dec 30;20(1):1031
pubmed: 31888477
J Bone Miner Res. 2010 Nov;25(11):2460-9
pubmed: 20533376
NPJ Aging Mech Dis. 2021 Apr 1;7(1):8
pubmed: 33795658
Avian Pathol. 2017 Dec;46(6):683-694
pubmed: 28669198
BMC Genet. 2020 Jun 3;21(1):58
pubmed: 32493207
Inflamm Res. 2014 Mar;63(3):239-47
pubmed: 24316866
Front Vet Sci. 2020 Aug 04;7:458
pubmed: 32851035
Vet J. 2013 Dec;198(3):616-9
pubmed: 24129110
Postepy Hig Med Dosw (Online). 2013 Aug 26;67:887-95
pubmed: 24018454
Sci Rep. 2016 Mar 01;6:22511
pubmed: 26928655
J Toxicol Sci. 2007 Dec;32(5):555-64
pubmed: 18198485
Sci Rep. 2016 May 13;6:25882
pubmed: 27174843
Exp Mol Med. 2016 Apr 01;48:e224
pubmed: 27034026
Sci Rep. 2020 Nov 5;10(1):19191
pubmed: 33154530
Nucleic Acids Res. 2016 Jan 4;44(D1):D1214-9
pubmed: 26467479
Lipids Health Dis. 2022 Jan 7;21(1):5
pubmed: 34996476
J Cell Physiol. 2018 Aug;233(8):6241-6249
pubmed: 29345324
Menopause. 2018 Nov;25(11):1339-1353
pubmed: 30358731
J Cell Physiol. 2018 Mar;233(3):2279-2291
pubmed: 28708257
Vet Rec. 1999 Jun 12;144(24):668-71
pubmed: 10404606
J Bone Miner Res. 2015 Nov;30(11):1945-55
pubmed: 26358868
PLoS One. 2015 Nov 16;10(11):e0142319
pubmed: 26569484
Front Vet Sci. 2021 Feb 01;8:640901
pubmed: 33634182
Animal. 2019 Oct;13(10):2365-2372
pubmed: 30894238
Front Endocrinol (Lausanne). 2020 Sep 23;11:578194
pubmed: 33071983
Poult Sci. 2012 Apr;91(4):870-83
pubmed: 22399726
Sci Rep. 2019 Dec 17;9(1):19265
pubmed: 31848455
Nucleic Acids Res. 2021 Jul 2;49(W1):W388-W396
pubmed: 34019663
Biol Cell. 2009 Mar;101(3):133-40
pubmed: 18666888
Calcif Tissue Int. 2012 May;90(5):404-10
pubmed: 22434366
Biochem Pharmacol. 2021 May;187:114425
pubmed: 33482152
mBio. 2019 Mar 19;10(2):
pubmed: 30890614
Endocrinology. 1998 Jan;139(1):51-6
pubmed: 9421397
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617
pubmed: 29140435
Biotechnol Appl Biochem. 2017 Nov;64(6):836-842
pubmed: 28791738
Poult Sci. 2013 Nov;92(11):2811-26
pubmed: 24135583
J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):393-7
pubmed: 14623536
Poult Sci. 2017 May 1;96(5):1033-1040
pubmed: 27965410
Poult Sci. 2016 Feb;95(2):325-44
pubmed: 26527707
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13816-9
pubmed: 9391110
Poult Sci. 2020 Nov;99(11):5422-5429
pubmed: 33142459
Avian Dis. 2009 Mar;53(1):21-5
pubmed: 19431999
J Leukoc Biol. 2005 Mar;77(3):388-99
pubmed: 15591425
Animals (Basel). 2022 May 24;12(11):
pubmed: 35681802
Microb Cell. 2017 Nov 22;5(2):74-87
pubmed: 29417056
Int J Mol Sci. 2018 Jan 04;19(1):
pubmed: 29300344
J Steroid Biochem Mol Biol. 2011 May;125(1-2):57-65
pubmed: 20736065
Malays J Med Sci. 2008 Jan;15(1):4-12
pubmed: 22589609
Trends Pharmacol Sci. 2003 Jun;24(6):290-7
pubmed: 12823955
Front Physiol. 2022 Aug 08;13:941134
pubmed: 36003650
Immunol Rev. 2009 May;229(1):152-72
pubmed: 19426221
Front Endocrinol (Lausanne). 2013 Jan 22;3:183
pubmed: 23346077
Poult Sci. 2022 May;101(5):101750
pubmed: 35278754
Biochem Biophys Res Commun. 2019 Nov 12;519(3):445-452
pubmed: 31526569
IUBMB Life. 2019 Dec;71(12):1916-1928
pubmed: 31317664
Geroscience. 2021 Apr;43(2):859-868
pubmed: 32789662
Cardiovasc Res. 2014 Dec 1;104(3):477-88
pubmed: 25341895
Biomed Res Int. 2015;2015:421746
pubmed: 26247020
Bioinformatics. 2008 Nov 1;24(21):2534-6
pubmed: 18606607
Autoimmunity. 2005 Aug;38(5):369-75
pubmed: 16227152