Deciphering the tumour immune microenvironment cell by cell.
immune checkpoint inhibitors
single-cell analysis
tumour microenvironment
Journal
Immuno-oncology technology
ISSN: 2590-0188
Titre abrégé: Immunooncol Technol
Pays: England
ID NLM: 9918281581106676
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
medline:
26
5
2023
pubmed:
26
5
2023
entrez:
26
5
2023
Statut:
epublish
Résumé
Immune checkpoint inhibitors (ICIs) have rejuvenated therapeutic approaches in oncology. Although responses tend to be durable, response rates vary in many cancer types. Thus, the identification and validation of predictive biomarkers is a key clinical priority, the answer to which is likely to lie in the tumour microenvironment (TME). A wealth of data demonstrates the huge impact of the TME on ICI response and resistance. However, these data also reveal the complexity of the TME composition including the spatiotemporal interactions between different cell types and their dynamic changes in response to ICIs. Here, we briefly review some of the modalities that sculpt the TME, in particular the metabolic milieu, hypoxia and the role of cancer-associated fibroblasts. We then discuss recent approaches to dissect the TME with a focus on single-cell RNA sequencing, spatial transcriptomics and spatial proteomics. We also discuss some of the clinically relevant findings these multi-modal analyses have yielded.
Identifiants
pubmed: 37234284
doi: 10.1016/j.iotech.2023.100383
pii: S2590-0188(23)00011-4
pmc: PMC10206805
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100383Informations de copyright
© 2023 The Author(s).
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