Blood-brain barrier remodeling in an organ-on-a-chip device shows Dkk1 to be a regulator of early metastasis.

blood brain barrier cancer dkk-1 metabolites metastasis microenvironment microfluidic secretions secretome

Journal

Advanced nanobiomed research
ISSN: 2699-9307
Titre abrégé: Adv Nanobiomed Res
Pays: Germany
ID NLM: 101773117

Informations de publication

Date de publication:
Apr 2023
Historique:
pmc-release: 01 04 2024
medline: 26 5 2023
pubmed: 26 5 2023
entrez: 26 5 2023
Statut: ppublish

Résumé

Brain metastases are the most lethal progression event, in part because the biological processes underpinning brain metastases are poorly understood. There is a paucity of realistic models of metastasis, as current

Identifiants

pubmed: 37234365
doi: 10.1002/anbr.202200036
pmc: PMC10208594
mid: NIHMS1872784
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : R33 CA261696
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046592
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI116482
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009676
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002240
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA245597
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA196018
Pays : United States

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Auteurs

Trisha M Westerhof (TM)

Michigan Medicine, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Benjamin A Yang (BA)

School of Engineering, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Nathan M Merill (NM)

Michigan Medicine, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Joel A Yates (JA)

Michigan Medicine, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Megan Altemus (M)

Michigan Medicine, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Liam Russell (L)

School of Engineering, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Anna J Miller (AJ)

School of Engineering, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Liwei Bao (L)

Michigan Medicine, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Zhifen Wu (Z)

Michigan Medicine, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Peter J Ulintz (PJ)

Michigan Medicine, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Carlos A Aguilar (CA)

School of Engineering, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Aki Morikawa (A)

Michigan Medicine, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Maria G Castro (MG)

Michigan Medicine, Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Michigan Medicine, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.

Sofia D Merajver (SD)

Michigan Medicine, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Christopher R Oliver (CR)

Michigan Medicine, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Classifications MeSH