COVID-19 vaccination in adults with inflammatory bowel disease.
COVID-19
Crohn’s disease
inflammatory bowel disease
ulcerative colitis
vaccine
Journal
Therapeutic advances in gastroenterology
ISSN: 1756-283X
Titre abrégé: Therap Adv Gastroenterol
Pays: England
ID NLM: 101478893
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
12
2022
accepted:
16
04
2023
medline:
26
5
2023
pubmed:
26
5
2023
entrez:
26
5
2023
Statut:
epublish
Résumé
Patients with inflammatory bowel disease (IBD) are not at increased risk of SARS-CoV-2 infection compared to the general population, and most are not at increased risk for severe disease. COVID-19 is nonetheless common, and vaccination is critical. Four safe and efficacious vaccines are now available for the prevention of COVID-19, with most data available for mRNA vaccines. Patients with IBD have a robust humoral response to vaccination with rates of seroconversion exceeding 95% following a two-dose mRNA vaccine series and 99% following a three-dose mRNA series, although those on certain therapies including anti-tumor necrosis factor α agents may have lower antibody concentrations and waning of antibodies over time. Additionally, rates of cell-mediated immune response, even in those patients with IBD who did not have evidence of humoral immunity, are high. Vaccines are safe and have not been associated with flares in disease activity. Gastroenterology providers should take an active role in ensuring patients with IBD are appropriately vaccinated against COVID-19.
Identifiants
pubmed: 37234702
doi: 10.1177/17562848231173130
pii: 10.1177_17562848231173130
pmc: PMC10203854
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
17562848231173130Informations de copyright
© The Author(s), 2023.
Déclaration de conflit d'intérêts
FC has received research support from Takeda Pharmaceuticals and Sanofi. He has been a consultant for Takeda, Arena Pharmaceuticals, GSK, and Celgene. Other authors disclose no conflicts of interest.
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