Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar.
Pashtun population
bioinformatics
risk variants
type 2 diabetes
whole exome sequencing
Journal
Journal of the ASEAN Federation of Endocrine Societies
ISSN: 2308-118X
Titre abrégé: J ASEAN Fed Endocr Soc
Pays: Philippines
ID NLM: 8608483
Informations de publication
Date de publication:
2023
2023
Historique:
received:
03
06
2021
accepted:
18
09
2021
medline:
29
5
2023
pubmed:
26
5
2023
entrez:
26
5
2023
Statut:
ppublish
Résumé
To investigate the association between the single nucleotide polymorphism (SNP) rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes mellitus (T2DM) and to examine the impact of this variant on pancreatic beta-cell function in the Myanmar population. A case-control study was undertaken in 100 subjects with T2DM and 113 controls. The SNP rs7903146 was genotyped using the allele-specific polymerase chain reaction method. Plasma glucose and serum insulin levels were determined using the enzymatic colorimetric method and ELISA respectively. Beta-cell function was calculated by the HOMA-β formula. The frequencies of carrier genotypes (CT and TT) were higher in subjects with T2DM than in controls. The minor T alleles of rs7903146 were found to statistically increase type 2 diabetes risk than the C allele with an allelic odds ratio of 2.07 (95% CI 1.39-3.09, p=0.0004). The mean HOMA-β level of the group with non-carrier genotype (CC) was significantly higher than that of the groups with carrier genotypes (CT and TT) in subjects with T2DM and controls with a p-value of 0.0003 and less than 0.0001, respectively. The rs7903146 variant of the TCF7L2 gene was found to be associated with T2DM and low β-cell function among Myanmar subjects.
Identifiants
pubmed: 37234929
doi: 10.15605/jafes.037.S2
pii: JAFES-38-S1-41
pmc: PMC10207866
doi:
Substances chimiques
T Cell Transcription Factor 1
0
Transcription Factor 7-Like 2 Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-47Informations de copyright
© 2022 Journal of the ASEAN Federation of Endocrine Societies.
Déclaration de conflit d'intérêts
The authors declared no conflict of interest.
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