Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes.

Human Genetics Molecular genetics

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
16 Jun 2023
Historique:
received: 13 12 2022
revised: 20 03 2023
accepted: 02 05 2023
medline: 26 5 2023
pubmed: 26 5 2023
entrez: 26 5 2023
Statut: epublish

Résumé

Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive disease characterized by severe and childhood onset organ-specific autoimmunity caused by mutations in the autoimmune regulator (

Identifiants

pubmed: 37235056
doi: 10.1016/j.isci.2023.106818
pii: S2589-0042(23)00895-7
pmc: PMC10206195
doi:

Types de publication

Journal Article

Langues

eng

Pagination

106818

Informations de copyright

© 2023 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Références

Nat Genet. 1997 Dec;17(4):393-8
pubmed: 9398839
J Clin Immunol. 2012 Apr;32(2):230-7
pubmed: 22127461
Hepatology. 2021 Mar;73(3):1088-1104
pubmed: 32557834
Virchows Arch. 2018 Jul;473(1):121-125
pubmed: 29374317
J Endocrinol Invest. 2021 Nov;44(11):2493-2510
pubmed: 34003463
Hum Mutat. 2001 Sep;18(3):205-11
pubmed: 11524731
N Engl J Med. 2018 Mar 22;378(12):1132-1141
pubmed: 29562162
J Med Genet. 1992 Nov;29(11):824-6
pubmed: 1453436
J Clin Endocrinol Metab. 2007 Feb;92(2):595-603
pubmed: 17118990
Cell Mol Immunol. 2021 May;18(5):1122-1140
pubmed: 33795850
J Allergy Clin Immunol. 2014 Dec;134(6):1354-1364.e6
pubmed: 25174867
J Clin Immunol. 2022 May;42(4):904-906
pubmed: 35312911
J Clin Endocrinol Metab. 2000 Aug;85(8):2944-50
pubmed: 10946908
JCI Insight. 2016 Aug 18;1(13):
pubmed: 27588307
Blood. 1994 Jun 1;83(11):3245-54
pubmed: 7514905
J Clin Endocrinol Metab. 2008 Nov;93(11):4389-97
pubmed: 18728167
N Engl J Med. 1990 Jun 28;322(26):1829-36
pubmed: 2348835
Endocr Connect. 2017 Jul;6(5):289-296
pubmed: 28446514
J Clin Endocrinol Metab. 2016 Aug;101(8):2975-83
pubmed: 27253668
Science. 2013 Mar 8;339(6124):1219-24
pubmed: 23471412
Nat Commun. 2021 Feb 11;12(1):959
pubmed: 33574239
Sci Transl Med. 2015 Jun 17;7(292):292ra101
pubmed: 26084804
Nature. 2021 Jun;594(7863):398-402
pubmed: 34012112
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15878-83
pubmed: 18840680
Clin J Gastroenterol. 2022 Feb;15(1):112-116
pubmed: 34676508
Autoimmunity. 2010 Aug;43(5-6):413-27
pubmed: 20380583
Nat Commun. 2021 Jun 18;12(1):3761
pubmed: 34145262
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4396-401
pubmed: 19251657
Br J Cancer. 2008 Jan 29;98(2):474-9
pubmed: 18087273
Immunity. 2015 Jun 16;42(6):1185-96
pubmed: 26084028
J Exp Med. 2021 Nov 1;218(11):
pubmed: 34477806
Am J Hum Genet. 1998 Dec;63(6):1675-84
pubmed: 9837820
J Exp Med. 2007 Mar 19;204(3):475-80
pubmed: 17353370
Immunity. 2005 Aug;23(2):227-39
pubmed: 16111640
Clin Exp Immunol. 2003 Apr;132(1):128-36
pubmed: 12653847
Hum Genet. 1998 Oct;103(4):428-34
pubmed: 9856486
Immunity. 2016 May 17;44(5):1102-13
pubmed: 27130899
Nucleic Acids Res. 2012 Dec;40(22):11756-68
pubmed: 23074189
Atherosclerosis. 2011 Oct;218(2):423-30
pubmed: 21868016
Front Immunol. 2021 Mar 18;12:655354
pubmed: 33815417

Auteurs

Bergithe E Oftedal (BE)

Department of Clinical Science, University of Bergen and Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Kristian Assing (K)

Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.

Safa Baris (S)

Marmara University, Faculty of Medicine, Pediatric Allergy and Immunology, Istanbul, Turkey.
Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.

Stephanie L Safgren (SL)

Center for Individualized Medicine, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Isik S Johansen (IS)

Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.

Marianne Antonius Jakobsen (MA)

Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.

Dusica Babovic-Vuksanovic (D)

Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.

Katherine Agre (K)

Invitae, San Francisco, CA, USA.

Eric W Klee (EW)

Mayo Clinic, Department of Quantitative Health Sciences, Rochester, MN, USA.

Emina Majcic (E)

Department of Clinical Science, University of Bergen and Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Elise M N Ferré (EMN)

Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

Monica M Schmitt (MM)

Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

Tom DiMaggio (T)

Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

Lindsey B Rosen (LB)

Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

Muhammad Obaidur Rahman (MO)

Department of Clinical Science, University of Bergen and Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Dionisios Chrysis (D)

Department of Pediatrics, Division of Pediatric Endocrinology, Medical School, University of Patras, Rion, Greece.

Aristeidis Giannakopoulos (A)

Department of Pediatrics, Division of Pediatric Endocrinology, Medical School, University of Patras, Rion, Greece.

Maria Tallon Garcia (MT)

Pediatric Hematology and Oncology Department, Hospital Álvaro Cunqueiro, Vigo, Spain.

Luis Ignacio González-Granado (LI)

Unidad de Inmunodeficiencias, Pediatría, Instituto de Investigación Hospital 12 de Octubre, Facultad de Medicina, Universidad Complutense, Madrid, Spain.

Katherine Stanley (K)

Mid-Atlantic Permanente Medical Group, Kaiser Permanente MidAtlantic, Rockville, MD, USA.

Jessica Galant-Swafford (J)

Division of Allergy & Clinical Immunology, National Jewish Health, Denver, CO, USA.

Pim Suwannarat (P)

Mid-Atlantic Permanente Medical Group, Kaiser Permanente MidAtlantic, Rockville, MD, USA.

Isabelle Meyts (I)

Department of Pediatrics, University Hospital Leuven, Laboratory for Inborn Errors of Immunity, Department of Microbiology Immunology and Transplantation, KU Leuven, Leuven, Belgium.

Michail S Lionakis (MS)

Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

Eystein S Husebye (ES)

Department of Clinical Science, University of Bergen and Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Classifications MeSH