Vitamin B
Journal
Cell reports. Physical science
ISSN: 2666-3864
Titre abrégé: Cell Rep Phys Sci
Pays: United States
ID NLM: 101769239
Informations de publication
Date de publication:
19 Apr 2023
19 Apr 2023
Historique:
medline:
26
5
2023
pubmed:
26
5
2023
entrez:
26
5
2023
Statut:
ppublish
Résumé
Epoxide ring-opening reactions have long been utilized to furnish alcohol products that are valuable in many subfields of chemistry. While many epoxide-opening reactions are known, the hydrogenative opening of epoxides via ionic means remains challenging because of harsh conditions and reactive hydride nucleophiles. Recent progress has shown that radical chemistry can achieve hydrogenative epoxide ring opening under relatively mild conditions; however, these methods invariably require oxophilic metal catalysts and sensitive reagents. In response to these challenges, we report a new approach to epoxide ring-opening hydrogenation using bio-inspired Earth-abundant vitamin B
Identifiants
pubmed: 37235063
doi: 10.1016/j.xcrp.2023.101372
pmc: PMC10210593
mid: NIHMS1894097
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM142738
Pays : United States
Déclaration de conflit d'intérêts
DECLARATION OF INTERESTS The authors declare no competing interests.
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