Biological Activity of Naphthoquinones Derivatives in the Search of Anticancer Lead Compounds.
cytotoxic activity
flow cytometry
juglone
lawsone
naphthoquinones
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
20 05 2023
20 05 2023
Historique:
received:
27
04
2023
revised:
15
05
2023
accepted:
18
05
2023
medline:
29
5
2023
pubmed:
26
5
2023
entrez:
26
5
2023
Statut:
epublish
Résumé
Naphthoquinones are a valuable source of secondary metabolites that are well known for their dye properties since ancient times. A wide range of biological activities have been described highlighting their cytotoxic activity, gaining the attention of researchers in recent years. In addition, it is also worth mentioning that many anticancer drugs possess a naphthoquinone backbone in their structure. Considering this background, the work described herein reports the evaluation of the cytotoxicity of different acyl and alkyl derivatives from juglone and lawsone that showed the best activity results from a etiolated wheat coleoptile bioassay. This bioassay is rapid, highly sensitive to a wide spectrum of activities, and is a powerful tool for detecting biologically active natural products. A preliminary cell viability bioassay was performed on cervix carcinoma (HeLa) cells for 24 h. The most promising compounds were further tested for apoptosis on different tumoral (IGROV-1 and SK-MEL-28) and non-tumoral (HEK-293) cell lines by flow cytometry. Results reveal that derivatives from lawsone (particularly derivative
Identifiants
pubmed: 37235382
pii: toxins15050348
doi: 10.3390/toxins15050348
pmc: PMC10222971
pii:
doi:
Substances chimiques
lawsone
TLH4A6LV1W
Naphthoquinones
0
Antineoplastic Agents
0
Etoposide
6PLQ3CP4P3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Cancer Lett. 2015 Feb 1;357(1):8-42
pubmed: 25444899
J Nat Prod. 2022 Jun 24;85(6):1503-1513
pubmed: 35687347
Chem Biol Interact. 2020 Aug 25;327:109142
pubmed: 32610056
Biochem J. 1997 Aug 15;326 ( Pt 1):1-16
pubmed: 9337844
Adv Drug Deliv Rev. 2020 Jan 1;153:54-64
pubmed: 31705912
Chin Clin Oncol. 2020 Aug;9(4):47
pubmed: 32648448
Chem Pharm Bull (Tokyo). 2020;68(1):46-57
pubmed: 31902901
Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 15;139:477-87
pubmed: 25576946
ChemMedChem. 2019 Mar 5;14(5):532-544
pubmed: 30600915
J Immunol Methods. 1995 Jul 17;184(1):39-51
pubmed: 7622868
Int J Cancer. 2022 Nov 1;151(9):1535-1541
pubmed: 35322413
Pest Manag Sci. 2018 Mar;74(3):682-694
pubmed: 29024464
Bioorg Med Chem Lett. 2021 Jun 1;41:127976
pubmed: 33766765
Molecules. 2019 Nov 18;24(22):
pubmed: 31752252
Int J Nanomedicine. 2021 Feb 03;16:753-761
pubmed: 33568905
Cell Immunol. 2010;261(1):1-8
pubmed: 19969290
Cancer Cell Int. 2019 Aug 2;19:207
pubmed: 31388334
Chem Biol Interact. 2022 Dec 1;368:110198
pubmed: 36179774
Chem Biol Drug Des. 2021 Jul;98(1):144-165
pubmed: 33963665
Molecules. 2020 Oct 21;25(20):
pubmed: 33096836
Planta Med. 2011 Dec;77(18):2003-12
pubmed: 21800278
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Curr Drug Targets. 2012 Dec;13(14):1777-98
pubmed: 23140289
Anticancer Agents Med Chem. 2006 Sep;6(5):489-99
pubmed: 17017857
Biologicals. 2008 Jul;36(4):263-8
pubmed: 18378163
Expert Opin Ther Pat. 2013 Sep;23(9):1087-108
pubmed: 23651032
Molecules. 2015 Nov 06;20(11):20079-106
pubmed: 26561798
Curr Protoc Immunol. 2015 Nov 02;111:A3.B.1-A3.B.3
pubmed: 26529666
Cancers (Basel). 2022 Apr 29;14(9):
pubmed: 35565359
JAAD Int. 2021 Jan 04;2:98-108
pubmed: 34409358
J Adv Res. 2021 Jun 16;36:223-247
pubmed: 35127174
Antioxidants (Basel). 2022 Mar 30;11(4):
pubmed: 35453348
Chem Biol Interact. 2010 Mar 30;184(3):439-48
pubmed: 20138029
Chem Biol Drug Des. 2018 Mar;91(3):681-690
pubmed: 29130595
Apoptosis. 2019 Feb;24(1-2):184-197
pubmed: 30498998
Molecules. 2015 Jun 30;20(7):11994-2015
pubmed: 26133763
Pharmaceuticals (Basel). 2022 Apr 27;15(5):
pubmed: 35631366
Bioorg Med Chem. 2013 Aug 1;21(15):4662-9
pubmed: 23791367