Generating parallel representations of position and identity in the olfactory system.
connectomics
neural circuits
pheromones
sensory physiology
sexual dimorphism
social behavior
stereo smell
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
08 06 2023
08 06 2023
Historique:
received:
27
05
2022
revised:
07
12
2022
accepted:
28
04
2023
medline:
12
6
2023
pubmed:
27
5
2023
entrez:
26
5
2023
Statut:
ppublish
Résumé
In Drosophila, a dedicated olfactory channel senses a male pheromone, cis-vaccenyl acetate (cVA), promoting female courtship while repelling males. Here, we show that separate cVA-processing streams extract qualitative and positional information. cVA sensory neurons respond to concentration differences in a 5-mm range around a male. Second-order projection neurons encode the angular position of a male by detecting inter-antennal differences in cVA concentration, which are amplified through contralateral inhibition. At the third circuit layer, we identify 47 cell types with diverse input-output connectivity. One population responds tonically to male flies, a second is tuned to olfactory looming, while a third integrates cVA and taste to coincidentally promote female mating. The separation of olfactory features resembles the mammalian what and where visual streams; together with multisensory integration, this enables behavioral responses appropriate to specific ethological contexts.
Identifiants
pubmed: 37236194
pii: S0092-8674(23)00472-5
doi: 10.1016/j.cell.2023.04.038
pmc: PMC10403364
pii:
doi:
Substances chimiques
Drosophila Proteins
0
Receptors, Odorant
0
cis-vaccenyl acetate
0
Pheromones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2556-2573.e22Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC-U105188491
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203261/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 110232/Z/15/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2023 MRC Laboratory of Molecular Biology. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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