Duchenne Muscular Dystrophy Fatigue Trajectories.
Journal
Neuropediatrics
ISSN: 1439-1899
Titre abrégé: Neuropediatrics
Pays: Germany
ID NLM: 8101187
Informations de publication
Date de publication:
04 Jul 2023
04 Jul 2023
Historique:
pubmed:
27
5
2023
medline:
27
5
2023
entrez:
26
5
2023
Statut:
aheadofprint
Résumé
Children with Duchenne muscular dystrophy (DMD) are at risk of experiencing fatigue that negatively impacts their health-related quality of life (HRQoL). This study aimed to assess the association between fatigue and HRQoL, by examining fatigue trajectories over 48 weeks, and assessing factors associated with these fatigue trajectories. The study sample consisted of 173 DMD subjects enrolled in a 48-week-long phase 2 clinical trial (NCT00592553) for a novel therapeutic who were between the ages of 5 and 16 years. The results of regression modeling show baseline fatigue and baseline HRQoL ( This study identified fatigue trajectories and risk factors associated with greater fatigue, helping clinicians and researchers identify the profile of fatigue in DMD children.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : PTC Therapeutics
ID : Investigator initiated grant
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
None declared.