From in vivo to in vitro: exploring the key molecular and cellular aspects of human female gametogenesis.
Artificial gametes
Female germ cells
Granulosa cells
Human oogenesis
Ovarian somatic cells
Primordial germ cells
Journal
Human cell
ISSN: 1749-0774
Titre abrégé: Hum Cell
Pays: Japan
ID NLM: 8912329
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
20
03
2023
accepted:
17
05
2023
medline:
23
6
2023
pubmed:
27
5
2023
entrez:
26
5
2023
Statut:
ppublish
Résumé
Human oogenesis is a highly complex and not yet fully understood process due to ethical and technological barriers that limit studies in the field. In this context, replicating female gametogenesis in vitro would not only provide a solution for some infertility problems, but also be an excellent study model to better understand the biological mechanisms that determine the formation of the female germline. In this review, we explore the main cellular and molecular aspects involved in human oogenesis and folliculogenesis in vivo, from the specification of primordial germ cells (PGCs) to the formation of the mature oocyte. We also sought to describe the important bidirectional relationship between the germ cell and the follicular somatic cells. Finally, we address the main advances and different methodologies used in the search for obtaining cells of the female germline in vitro.
Identifiants
pubmed: 37237248
doi: 10.1007/s13577-023-00921-7
pii: 10.1007/s13577-023-00921-7
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1283-1311Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de Minas Gerais
ID : RED-00079-22
Organisme : Fundação de Amparo à Pesquisa do Estado de Minas Gerais
ID : RED-00135-22
Informations de copyright
© 2023. The Author(s) under exclusive licence to Japan Human Cell Society.
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