Correlation Between PAPP-A Levels Determined During the First Trimester and Birth Weight at Full-Term.
First-trimester combined screening (FTCS)
Intrauterine restricted growth (IURG)
Large for gestational age (LGE)
Percentile (p)
Pregnancy-associated plasma protein-A (PAPP-a)
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
29
01
2023
accepted:
10
05
2023
medline:
15
11
2023
pubmed:
27
5
2023
entrez:
26
5
2023
Statut:
ppublish
Résumé
Foetal birth weight is an important determinant of perinatal health. For this reason, various methods have been investigated for estimating this weight during pregnancy. The aim of this study is to evaluate the possible relationship between full-term birth weight and pregnancy-associated plasma protein-A (PAPP-A) levels determined during the first trimester as part of combined screening for aneuploidy carried out in pregnant women. We carried out a single-centre study including pregnant women who were being followed up by the Obstetrics Service Care Units of the XXI de Santiago de Compostela e Barbanza Foundation, who gave birth from March 1, 2015, to March 1, 2017, and who had undergone their first-trimester combined chromosomopathy screening. The sample included a total of 2794 women. We found a significant correlation between MoM PAPP-A and foetal birth weight. When MoM PAPP-A was measured at extremely low levels (< 0.3) during the first trimester, the OR for giving birth to a foetus with weight < p10, adjusting for gestational age and sex, was 2.74. For low levels of MoM PAPP-A (0.3-0.44), the OR was 1.52. With regard to the value of MOM PAPP-A levels as a predictor of foetal macrosomia, a correlation could be observed with elevated levels, although this was not statistically significant. PAPP-A determined during the first trimester acts as a predictor of foetal weight at term as well as for foetal growth disorders.
Identifiants
pubmed: 37237249
doi: 10.1007/s43032-023-01270-4
pii: 10.1007/s43032-023-01270-4
pmc: PMC10643350
doi:
Substances chimiques
Pregnancy-Associated Plasma Protein-A
EC 3.4.24.-
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3235-3242Informations de copyright
© 2023. The Author(s).
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