Natural exosome-like nanoparticles derived from ancient medicinal insect Periplaneta americana L. as a novel diabetic wound healing accelerator.
Autophagy
Exosome-like nanoparticles
Periplaneta americana (L.)
Proteomics
Small RNA
Wound healing
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
26 May 2023
26 May 2023
Historique:
received:
21
02
2023
accepted:
09
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
26
5
2023
Statut:
epublish
Résumé
Along with the recognized therapeutic outcomes of regenerative medicine, extracellular vesicles and their exosome subsets have become an alternative option for wound healing. Periplaneta americana L. (PA), an ancient and traditional medicinal insect, has been around for 300 million years, and displays magic formidable vitality and environmental adaptive ability. The linkage between intrinsic amputation regeneration feature and the acknowledged wound healing medicinal benefit of PA has never been revealed. Herein, inspired by the ability of exosomes to participate in the interkingdom communication, we explored whether this effect was ascribed to PA derived exosome-like nanoparticles (PA-ELNs). PA-ELNs were extracted by differential velocity centrifugation approach and characterized by DLS, NTA and TEM. Their cargoes were analyzed by LC-MS/MS proteomics and small RNA-seq analysis. The wound healing activity was verified in vivo and in vitro. PA-ELNs with a concentration of 2.33x10
Identifiants
pubmed: 37237376
doi: 10.1186/s12951-023-01923-1
pii: 10.1186/s12951-023-01923-1
pmc: PMC10214631
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
169Subventions
Organisme : the Scientific and technological innovation project of China Academy of Chinese Medical Sciences
ID : CI2021A04305
Organisme : the Fundamental Research Funds for the Central Public Welfare Research Institutes
ID : ZZ13-YQ-041, ZXKT21013
Organisme : the National Interdisciplinary Innovation Team of Traditional Chinese Medicine
ID : ZYYCXTD-D-202209
Informations de copyright
© 2023. The Author(s).
Références
Bioact Mater. 2021 Jun 23;8:341-354
pubmed: 34541405
Burns Trauma. 2022 Feb 16;10:tkac003
pubmed: 35187180
Diabetes Res Clin Pract. 2022 Jan;183:109126
pubmed: 34742784
Int J Mol Sci. 2019 Oct 05;20(19):
pubmed: 31590392
Biomed Pharmacother. 2020 Aug;128:110278
pubmed: 32480223
J Ethnopharmacol. 2023 Mar 25;304:116052
pubmed: 36529246
Nat Commun. 2018 Mar 20;9(1):1008
pubmed: 29559629
Int J Nanomedicine. 2019 Nov 01;14:8603-8610
pubmed: 31802872
Biomolecules. 2020 May 10;10(5):
pubmed: 32397678
Int J Nanomedicine. 2021 Jul 20;16:4891-4900
pubmed: 34321877
Acta Biomater. 2022 Mar 1;140:206-218
pubmed: 34879294
Theranostics. 2019 Jan 1;9(1):65-76
pubmed: 30662554
Autophagy. 2021 Sep;17(9):2128-2143
pubmed: 32866426
Stem Cells Int. 2019 Sep 9;2019:7132708
pubmed: 31582986
J Zhejiang Univ Sci B. 2022 Jul 15;23(7):547-563
pubmed: 35794685
J Nanobiotechnology. 2022 Mar 19;20(1):147
pubmed: 35305648
Appl Microbiol Biotechnol. 2016 Jul;100(14):6165-6181
pubmed: 27245678
Hepatol Commun. 2021 Feb 05;5(5):846-864
pubmed: 34027273
Mater Sci Eng C Mater Biol Appl. 2021 Aug;127:112245
pubmed: 34225884
Biomed Pharmacother. 2020 Sep;129:110287
pubmed: 32540643
J Ethnopharmacol. 2021 Jan 10;264:113052
pubmed: 32535239
J Nanobiotechnology. 2021 May 5;19(1):130
pubmed: 33952251
Acta Biomater. 2022 Jul 15;147:342-355
pubmed: 35580827
Biomed Pharmacother. 2019 Jun;114:108858
pubmed: 30986622
J Pharm Biomed Anal. 2020 Nov 30;191:113609
pubmed: 32966940
Int J Mol Sci. 2018 Oct 11;19(10):
pubmed: 30314356
J Extracell Vesicles. 2020 Aug 26;9(1):1809064
pubmed: 32944193
Int J Nanomedicine. 2021 Feb 26;16:1575-1586
pubmed: 33664572
Mech Ageing Dev. 2018 Jun;172:51-58
pubmed: 29132871
Chin Med. 2021 Jun 19;16(1):45
pubmed: 34147112
Int J Biol Macromol. 2022 Jun 1;209(Pt B):2130-2141
pubmed: 35500775
Evid Based Complement Alternat Med. 2021 Jun 3;2021:1334255
pubmed: 34122591
Asian J Pharm Sci. 2022 Mar;17(2):206-218
pubmed: 35582637
Cell Host Microbe. 2018 Nov 14;24(5):637-652.e8
pubmed: 30449315
Diabetes Res Clin Pract. 2022 Apr;186:109831
pubmed: 35306046
Theranostics. 2018 Jan 1;8(1):237-255
pubmed: 29290805
Biomaterials. 2021 Aug;275:120963
pubmed: 34153785
Nat Commun. 2019 Feb 27;10(1):959
pubmed: 30814518
Int J Mol Sci. 2017 Jul 03;18(7):
pubmed: 28671607
Pharmacol Res. 2021 Aug;170:105749
pubmed: 34214630
Int J Biol Macromol. 2020 Dec 1;164:3846-3857
pubmed: 32841667
Transl Androl Urol. 2022 Feb;11(2):202-212
pubmed: 35280667
J Nanobiotechnology. 2018 Oct 16;16(1):81
pubmed: 30326899
Sci Transl Med. 2021 Mar 17;13(585):
pubmed: 33731435
Burns. 2022 May;48(3):639-648
pubmed: 34716043
PLoS One. 2021 Sep 30;16(9):e0257633
pubmed: 34591894
Chin Med. 2019 Sep 18;14:33
pubmed: 31548851
J Ethnopharmacol. 2022 Jun 12;291:114884
pubmed: 34999145
Diabetes Res Clin Pract. 2022 May;187:109882
pubmed: 35487341
Oral Dis. 2013 Sep;19(6):551-8
pubmed: 23379329
Evid Based Complement Alternat Med. 2019 Dec 30;2019:3678714
pubmed: 31975998
Parasit Vectors. 2020 Jun 19;13(1):318
pubmed: 32560736
J Nanobiotechnology. 2022 Apr 29;20(1):206
pubmed: 35488343
Bioact Mater. 2022 Jul 01;20:561-573
pubmed: 35846841
Pharmacol Res. 2021 Dec;174:105841
pubmed: 34419563
PLoS One. 2019 Jun 12;14(6):e0217760
pubmed: 31188849
Acta Biochim Biophys Sin (Shanghai). 2018 May 1;50(5):491-498
pubmed: 29538616
Diabetes Res Clin Pract. 2023 Jan;195:110201
pubmed: 36493913
Theranostics. 2020 Apr 27;10(13):5914-5931
pubmed: 32483427
Exp Cell Res. 2017 Jun 15;355(2):83-94
pubmed: 28363830
Hum Cell. 2022 Sep;35(5):1375-1390
pubmed: 35751795
Acta Pharmacol Sin. 2022 Mar;43(3):645-658
pubmed: 33990765