Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI.
ALADDIN
Flow velocity
Magnetic resonance imaging
Meningeal lymphatic vessel
Non-invasive
Parasagittal
Perfusion imaging
Journal
Fluids and barriers of the CNS
ISSN: 2045-8118
Titre abrégé: Fluids Barriers CNS
Pays: England
ID NLM: 101553157
Informations de publication
Date de publication:
26 May 2023
26 May 2023
Historique:
received:
14
11
2022
accepted:
21
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
26
5
2023
Statut:
epublish
Résumé
The clearance pathways of brain waste products in humans are still under debate in part due to the lack of noninvasive imaging techniques for meningeal lymphatic vessels (mLVs). In this study, we propose a new noninvasive mLVs imaging technique based on an inter-slice blood perfusion MRI called alternate ascending/descending directional navigation (ALADDIN). ALADDIN with inversion recovery (IR) at single inversion time of 2300 ms (single-TI IR-ALADDIN) clearly demonstrated parasagittal mLVs around the human superior sagittal sinus (SSS) with better detectability and specificity than the previously suggested noninvasive imaging techniques. While in many studies it has been difficult to detect mLVs and confirm their signal source noninvasively, the detection of mLVs in this study was confirmed by their posterior to anterior flow direction and their velocities and morphological features, which were consistent with those from the literature. In addition, IR-ALADDIN was compared with contrast-enhanced black blood imaging to confirm the detection of mLVs and its similarity. For the quantification of flow velocity of mLVs, IR-ALADDIN was performed at three inversion times of 2000, 2300, and 2600 ms (three-TI IR-ALADDIN) for both a flow phantom and humans. For this preliminary result, the flow velocity of the dorsal mLVs in humans ranged between 2.2 and 2.7 mm/s. Overall, (i) the single-TI IR-ALADDIN can be used as a novel non-invasive method to visualize mLVs in the whole brain with scan time of ~ 17 min and (ii) the multi-TI IR-ALADDIN can be used as a way to quantify the flow velocity of mLVs with a scan time of ~ 10 min (or shorter) in a limited coverage. Accordingly, the suggested approach can be applied to noninvasively studying meningeal lymphatic flows in general and also understanding the clearance pathways of waste production through mLVs in humans, which warrants further investigation.
Identifiants
pubmed: 37237402
doi: 10.1186/s12987-023-00446-z
pii: 10.1186/s12987-023-00446-z
pmc: PMC10224581
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
37Subventions
Organisme : National Research Foundation of Korea
ID : RS-2023-00207783
Organisme : National Research Foundation of Korea
ID : RS-2023-00207783
Organisme : Korea Medical Device Development Fund
ID : RS-2020-KD000062
Informations de copyright
© 2023. The Author(s).
Références
J Digit Imaging. 2018 Jun;31(3):290-303
pubmed: 29181613
Nat Commun. 2022 Jan 11;13(1):203
pubmed: 35017525
J Neurosurg. 2014 Jan;120(1):218-27
pubmed: 23930855
Sci Rep. 2020 Sep 11;10(1):14974
pubmed: 32917953
Am J Physiol. 1996 Jan;270(1 Pt 2):H358-63
pubmed: 8769772
J Magn Reson Imaging. 1994 Jan-Feb;4(1):25-8
pubmed: 8148552
Biomolecules. 2022 May 25;12(6):
pubmed: 35740873
J Magn Reson Imaging. 2005 Jul;22(1):13-22
pubmed: 15971174
Brain Behav Immun. 2018 Oct;73:34-40
pubmed: 30055243
Cell Mol Life Sci. 2021 Mar;78(6):2429-2457
pubmed: 33427948
Front Pharmacol. 2021 Apr 28;12:655052
pubmed: 33995074
Magn Reson Med. 2004 Sep;52(3):679-82
pubmed: 15334591
Tomography. 2018 Sep;4(3):99-104
pubmed: 30320209
Microcirculation. 2006 Oct-Nov;13(7):597-610
pubmed: 16990218
J Exp Med. 2022 Aug 1;219(8):
pubmed: 35776089
Elife. 2022 Apr 29;11:
pubmed: 35486089
Fluids Barriers CNS. 2022 Mar 21;19(1):24
pubmed: 35313906
Elife. 2017 Oct 03;6:
pubmed: 28971799
Cells. 2021 Dec 01;10(12):
pubmed: 34943894
Front Hum Neurosci. 2022 Jan 21;15:737217
pubmed: 35126070
Radiology. 2008 Nov;249(2):644-52
pubmed: 18936318
Cell Res. 2020 Mar;30(3):229-243
pubmed: 32094452
J Clin Med. 2020 Oct 19;9(10):
pubmed: 33086702
J Clin Invest. 2017 Sep 1;127(9):3210-3219
pubmed: 28862640
Nature. 2015 Jul 16;523(7560):337-41
pubmed: 26030524
Nat Commun. 2020 Jan 17;11(1):354
pubmed: 31953399
Neuroscience. 2019 Aug 21;414:28-48
pubmed: 31279048
Breast Cancer. 2022 Sep;29(5):835-843
pubmed: 35553019
Magn Reson Med. 2012 Jan;67(1):42-9
pubmed: 21590721
J Magn Reson. 2005 Mar;173(1):97-115
pubmed: 15705518
Nature. 2019 Aug;572(7767):62-66
pubmed: 31341278
MAGMA. 2018 Jun;31(3):415-424
pubmed: 29110239
Neuroimage. 2006 Jul 1;31(3):1116-28
pubmed: 16545965
Magn Reson Med. 2008 Jul;60(1):213-9
pubmed: 18581383
Fluids Barriers CNS. 2020 Nov 30;17(1):71
pubmed: 33256800
Neuron. 2018 Oct 24;100(2):375-388
pubmed: 30359603
Nucl Med Mol Imaging. 2020 Oct;54(5):207-223
pubmed: 33088350
Magn Reson Med. 2011 Jun;65(6):1578-91
pubmed: 20860002
J Exp Med. 2015 Jun 29;212(7):991-9
pubmed: 26077718
Radiology. 2013 Dec;269(3):893-902
pubmed: 23864103
Magn Reson Med. 2012 Nov;68(5):1600-6
pubmed: 22287275