The role of the oral microbiome in obesity and metabolic disease: potential systemic implications and effects on taste perception.
Inflammation
Metabolic disease
Obesity
Oral microbiome
Taste perception
Journal
Nutrition journal
ISSN: 1475-2891
Titre abrégé: Nutr J
Pays: England
ID NLM: 101152213
Informations de publication
Date de publication:
27 05 2023
27 05 2023
Historique:
received:
03
03
2023
accepted:
10
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
26
5
2023
Statut:
epublish
Résumé
Obesity and its metabolic sequelae still comprise a challenge when it comes to understanding mechanisms, which drive these pandemic diseases. The human microbiome as a potential key player has attracted the attention of broader research for the past decade. Most of it focused on the gut microbiome while the oral microbiome has received less attention. As the second largest niche, the oral microbiome is associated with a multitude of mechanisms, which are potentially involved in the complex etiology of obesity and associated metabolic diseases. These mechanisms include local effects of oral bacteria on taste perception and subsequent food preference as well as systemic effects on adipose tissue function, the gut microbiome and systemic inflammation. This review summarizes a growing body of research, pointing towards a more prominent role of the oral microbiome in obesity and associated metabolic diseases than expected. Ultimately, our knowledge on the oral microbiome may support the development of new patient oriented therapeutic approaches inevitable to relieve the health burden of metabolic diseases and to reach long-term benefits in patients´ lives.
Identifiants
pubmed: 37237407
doi: 10.1186/s12937-023-00856-7
pii: 10.1186/s12937-023-00856-7
pmc: PMC10223863
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
28Informations de copyright
© 2023. The Author(s).
Références
Gut. 2016 May;65(5):740-8
pubmed: 26657899
Diabetes Metab J. 2020 Aug;44(4):509-528
pubmed: 32431111
Int J Obes (Lond). 2020 Mar;44(3):739-743
pubmed: 31388094
Front Cell Infect Microbiol. 2021 Jan 19;10:580577
pubmed: 33542905
Front Cell Infect Microbiol. 2020 Nov 23;10:600884
pubmed: 33330141
J Dent Res. 2020 Sep;99(10):1131-1139
pubmed: 32459164
PLoS One. 2012;7(5):e36557
pubmed: 22570725
Foods. 2021 Aug 26;10(9):
pubmed: 34574116
Sci Rep. 2018 Sep 19;8(1):14030
pubmed: 30232389
Eur J Pharmacol. 2004 Apr 12;489(3):139-49
pubmed: 15087236
Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E229-38
pubmed: 26627720
FEMS Microbiol Ecol. 2013 Aug;85(2):376-88
pubmed: 23614882
Cancers (Basel). 2021 Apr 28;13(9):
pubmed: 33924899
J Oral Maxillofac Pathol. 2019 Jan-Apr;23(1):122-128
pubmed: 31110428
mSphere. 2018 Oct 17;3(5):
pubmed: 30333180
J Periodontal Res. 2017 Jun;52(3):636-643
pubmed: 28177125
Nat Commun. 2020 Jan 17;11(1):362
pubmed: 31953381
Nature. 2014 Sep 4;513(7516):59-64
pubmed: 25079328
Crit Rev Oral Biol Med. 2000;11(2):216-29
pubmed: 12002816
Biomedicines. 2022 Dec 20;11(1):
pubmed: 36672511
Nat Rev Cardiol. 2023 Apr;20(4):217-235
pubmed: 36241728
BMC Neurosci. 2010 Jun 10;11:72
pubmed: 20537148
Spec Care Dentist. 2014 Jan-Feb;34(1):34-40
pubmed: 24382369
Diagnostics (Basel). 2021 Jul 16;11(7):
pubmed: 34359364
Sci Rep. 2018 Apr 30;8(1):6742
pubmed: 29713004
PLoS One. 2014 Jan 22;9(1):e85611
pubmed: 24465618
Nat Rev Neurosci. 2017 Aug;18(8):485-497
pubmed: 28655883
PLoS One. 2012;7(6):e39748
pubmed: 22768116
Annu Rev Immunol. 2011;29:415-45
pubmed: 21219177
Sci Rep. 2020 Feb 7;10(1):2133
pubmed: 32034250
Cureus. 2022 Feb 28;14(2):e22711
pubmed: 35386146
Front Pharmacol. 2019 May 22;10:572
pubmed: 31191312
Elife. 2019 Feb 12;8:
pubmed: 30747106
NPJ Biofilms Microbiomes. 2017 Jan 26;3:2
pubmed: 28649403
Periodontol 2000. 2021 Oct;87(1):107-131
pubmed: 34463991
Crit Rev Food Sci Nutr. 2022 Nov 3;:1-11
pubmed: 36419361
J Oral Microbiol. 2019 Aug 9;11(1):1650597
pubmed: 31489128
J Dent Res. 2013 Jun;92(6):485-91
pubmed: 23625375
J Dent Res. 2015 Dec;94(12):1628-37
pubmed: 26377570
Sci Rep. 2018 Jan 30;8(1):1902
pubmed: 29382867
Nature. 2006 Dec 21;444(7122):1022-3
pubmed: 17183309
J Clin Med. 2020 Aug 02;9(8):
pubmed: 32748883
J Alzheimers Dis. 2015;43(1):67-80
pubmed: 25061055
Gut. 2020 Oct;69(10):1796-1806
pubmed: 32317332
Periodontol 2000. 2002;28:12-55
pubmed: 12013340
J Clin Periodontol. 2009 Feb;36(2):89-99
pubmed: 19207883
Diabetes Care. 2004 Jan;27(1):47-52
pubmed: 14693965
J Clin Periodontol. 2013 Apr;40 Suppl 14:S30-50
pubmed: 23627333
J Oral Microbiol. 2019 Mar 18;11(1):1586422
pubmed: 30911359
J Periodontol. 2018 Feb;89(2):186-194
pubmed: 29520825
Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G824-G837
pubmed: 30118351
Microbes Infect. 2016 Dec;18(12):804-812
pubmed: 27565999
PeerJ. 2018 Mar 16;6:e4458
pubmed: 29576948
Int J Gen Med. 2013 May 24;6:383-6
pubmed: 23737674
Genome Biol. 2012 Jun 14;13(6):R42
pubmed: 22698087
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2365-70
pubmed: 19164560
J Oral Sci. 2017 Dec 27;59(4):549-555
pubmed: 28993578
Science. 2017 Oct 20;358(6361):359-365
pubmed: 29051379
mSphere. 2020 Sep 30;5(5):
pubmed: 32999079
Biomed Res Int. 2018 Jun 14;2018:2838052
pubmed: 30013981
J Child Obes. 2019;4(1):
pubmed: 31535093
Nature. 2006 Aug 24;442(7105):934-8
pubmed: 16929298
J Periodontol. 2000 Oct;71(10):1554-60
pubmed: 11063387
J Nutr Health Aging. 2018;22(7):802-804
pubmed: 30080223
Obesity (Silver Spring). 2012 Jan;20(1):157-64
pubmed: 21996660
J Clin Invest. 2012 Nov;122(11):4145-59
pubmed: 23041624
Physiol Rep. 2022 Apr;10(7):e15254
pubmed: 35384379
J Gastrointest Surg. 2010 Mar;14(3):449-61
pubmed: 20033346
J Dent Res. 2009 Jun;88(6):519-23
pubmed: 19587155
Nutrients. 2023 Feb 06;15(4):
pubmed: 36839184
Front Cell Infect Microbiol. 2014 Jul 29;4:98
pubmed: 25120956
Physiol Rev. 2016 Jan;96(1):151-76
pubmed: 26631596
J Vasc Res. 2005 Nov-Dec;42(6):517-25
pubmed: 16155368
FEMS Microbiol Rev. 2019 Jan 1;43(1):1-18
pubmed: 30219863
J Periodontol. 2013 Nov;84(11):1617-26
pubmed: 23289867
Int J Dent Hyg. 2003 Aug;1(3):151-8
pubmed: 16451515
Mol Immunol. 2015 Dec;68(2 Pt C):663-70
pubmed: 26552761
Front Oral Health. 2021 Sep 09;2:697428
pubmed: 35048037
Nutrients. 2019 May 24;11(5):
pubmed: 31137674
Sci Rep. 2019 Mar 5;9(1):3549
pubmed: 30837660
J Clin Periodontol. 2004 Jul;31(7):506-10
pubmed: 15191584
Front Immunol. 2019 Jun 25;10:1403
pubmed: 31293577
J Oral Microbiol. 2019 Apr 23;11(1):1605789
pubmed: 31069021
Diabetes Care. 2012 Aug;35(8):1654-62
pubmed: 22699287
BMC Gastroenterol. 2012 Feb 16;12:16
pubmed: 22340817
J Dent Res. 2020 Jun;99(6):739-745
pubmed: 32432524
Pediatrics. 2009 Apr;123(4):1177-83
pubmed: 19336378
J Oral Microbiol. 2010 Dec 21;2:
pubmed: 21523215
Front Nutr. 2023 Jan 11;9:1046454
pubmed: 36712531
Sci Rep. 2014 May 06;4:4828
pubmed: 24797416
PLoS One. 2018 Oct 1;13(10):e0204724
pubmed: 30273364
J Rheumatol. 2010 Jun;37(6):1105-12
pubmed: 20436074
J Neurosci. 2007 Oct 3;27(40):10840-8
pubmed: 17913917
Br J Nutr. 2012 Mar;107(5):621-30
pubmed: 21781379
Oral Microbiol Immunol. 2002 Apr;17(2):113-8
pubmed: 11929559
Malays Fam Physician. 2021 Sep 24;16(3):36-43
pubmed: 34938391
Cell Rep. 2020 Mar 24;30(12):4003-4015.e3
pubmed: 32209464
J Oral Microbiol. 2017 Jan 17;9(1):1270602
pubmed: 28326151
Sci Rep. 2017 Sep 18;7(1):11773
pubmed: 28924229
Beijing Da Xue Xue Bao Yi Xue Ban. 2018 Feb 18;50(1):5-12
pubmed: 29483715
Geriatr Nurs. 2016 Mar-Apr;37(2):128-36
pubmed: 26747405
Acta Diabetol. 2020 Dec;57(12):1445-1451
pubmed: 32676702
Inflamm Bowel Dis. 2011 Sep;17(9):1971-8
pubmed: 21830275
Trends Microbiol. 2005 Dec;13(12):589-95
pubmed: 16214341
Nature. 2017 Aug 17;548(7667):330-333
pubmed: 28792937
Bioessays. 2014 Oct;36(10):940-9
pubmed: 25103109
Diabetes Metab J. 2015 Jun;39(3):198-203
pubmed: 26124989
J Periodontol. 2010 Apr;81(4):520-6
pubmed: 20367095
Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):e17-8
pubmed: 15662025
J Oral Microbiol. 2012;4:
pubmed: 23119124
Genome Med. 2021 Jun 22;13(1):105
pubmed: 34158092
Genome Res. 2009 Dec;19(12):2317-23
pubmed: 19819907
Complement Med Res. 2018;25(3):191-197
pubmed: 28957816
Front Immunol. 2020 Oct 16;11:571731
pubmed: 33178196
Int J Oral Sci. 2019 Mar 5;11(1):10
pubmed: 30833566
Front Nutr. 2022 Jul 06;9:914715
pubmed: 35873415
J Med Dent Sci. 2003 Mar;50(1):101-7
pubmed: 12715926
Oral Dis. 2017 Apr;23(3):276-286
pubmed: 27219464
Periodontol 2000. 2021 Oct;87(1):299-314
pubmed: 34463987
Cell Mol Life Sci. 2015 Jan;72(2):217-36
pubmed: 25323130
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4592-8
pubmed: 20937873
Malays J Pathol. 2017 Apr;39(1):1-15
pubmed: 28413200
Cell Host Microbe. 2017 Jul 12;22(1):120-128.e4
pubmed: 28704648
Front Microbiol. 2018 Oct 24;9:2470
pubmed: 30405551
Environ Microbiol. 2011 Dec;13(12):3077-87
pubmed: 21906224
PLoS One. 2019 Sep 11;14(9):e0221656
pubmed: 31509575
Nat Commun. 2019 Mar 5;10(1):1048
pubmed: 30837463
Br Dent J. 2018 Mar 23;224(6):447-455
pubmed: 29569607
Medicina (Kaunas). 2021 Jun 30;57(7):
pubmed: 34209298
Lancet Gastroenterol Hepatol. 2021 Jun;6(6):411
pubmed: 34015350
Anaerobe. 2021 Aug;70:102248
pubmed: 32805390
PLoS Biol. 2018 Mar 20;16(3):e2001959
pubmed: 29558472
Int Immunopharmacol. 2009 Jan;9(1):38-42
pubmed: 18848647
J Formos Med Assoc. 2019 Mar;118 Suppl 1:S3-S9
pubmed: 30057153