Aminoglycosides for the Treatment of Severe Infection Due to Resistant Gram-Negative Pathogens.
aminoglycosides
gram-negative infections
multidrug-resistant
nebulization
pharmacokinetics
toxicity
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
06 May 2023
06 May 2023
Historique:
received:
30
03
2023
revised:
01
05
2023
accepted:
04
05
2023
medline:
27
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Aminoglycosides are a family of rapidly bactericidal antibiotics that often remain active against resistant Gram-negative bacterial infections. Over the past decade, their use in critically ill patients has been refined; however, due to their renal and cochleovestibular toxicity, their indications in the treatment of sepsis and septic shock have been gradually reduced. This article reviews the spectrum of activity, mode of action, and methods for optimizing the efficacy of aminoglycosides. We discuss the current indications for aminoglycosides, with an emphasis on multidrug-resistant Gram-negative bacteria, such as extended-spectrum β-lactamase-producing
Identifiants
pubmed: 37237763
pii: antibiotics12050860
doi: 10.3390/antibiotics12050860
pmc: PMC10215420
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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