Mangiferin Affects Melanin Synthesis by an Influence on Tyrosinase: Inhibition, Mechanism of Action and Molecular Docking Studies.
L-DOPA
active center
antioxidant
complex formation
enzyme inhibition
food browning
peripheral site
pigment
xanthone
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
28 Apr 2023
28 Apr 2023
Historique:
received:
05
03
2023
revised:
24
04
2023
accepted:
26
04
2023
medline:
27
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Mangiferin is a strong antioxidant that presents a wide range of biological activities. The aim of this study was to evaluate, for the first time, the influence of mangiferin on tyrosinase, an enzyme responsible for melanin synthesis and the unwanted browning process of food. The research included both the kinetics and molecular interactions between tyrosinase and mangiferin. The research proved that mangiferin inhibits tyrosinase activity in a dose-dependent manner with IC
Identifiants
pubmed: 37237882
pii: antiox12051016
doi: 10.3390/antiox12051016
pmc: PMC10215643
pii:
doi:
Types de publication
Journal Article
Langues
eng
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