Apolipoprotein D in Oxidative Stress and Inflammation.
4-hydroxynonenal
alzheimer
arachidonic acid
high density lipoprotein
lipid peroxidation
malondialdehyde
metabolism
obesity
polyunsaturated fatty acid
prostaglandins
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
28 Apr 2023
28 Apr 2023
Historique:
received:
11
04
2023
revised:
24
04
2023
accepted:
27
04
2023
medline:
27
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Apolipoprotein D (ApoD) is lipocalin able to bind hydrophobic ligands. The APOD gene is upregulated in a number of pathologies, including Alzheimer's disease, Parkinson's disease, cancer, and hypothyroidism. Upregulation of ApoD is linked to decreased oxidative stress and inflammation in several models, including humans, mice, Drosophila melanogaster and plants. Studies suggest that the mechanism through which ApoD modulates oxidative stress and regulate inflammation is via its capacity to bind arachidonic acid (ARA). This polyunsaturated omega-6 fatty acid can be metabolised to generate large variety of pro-inflammatory mediators. ApoD serves as a sequester, blocking and/or altering arachidonic metabolism. In recent studies of diet-induced obesity, ApoD has been shown to modulate lipid mediators derived from ARA, but also from eicosapentaenoic acid and docosahexaenoic acid in an anti-inflammatory way. High levels of ApoD have also been linked to better metabolic health and inflammatory state in the round ligament of morbidly obese women. Since ApoD expression is upregulated in numerous diseases, it might serve as a therapeutic agent against pathologies aggravated by OS and inflammation such as many obesity comorbidities. This review will present the most recent findings underlying the central role of ApoD in the modulation of both OS and inflammation.
Identifiants
pubmed: 37237893
pii: antiox12051027
doi: 10.3390/antiox12051027
pmc: PMC10215970
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Natural Sciences and Engineering Research Council
ID : RGPIN-2019-06738
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