Is Cancer Reversible? Rethinking Carcinogenesis Models-A New Epistemological Tool.
biological network
embryo development
microenvironment
morphogenesis
systems biology
tumor reversion
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
24 04 2023
24 04 2023
Historique:
received:
24
02
2023
revised:
17
04
2023
accepted:
19
04
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
A growing number of studies shows that it is possible to induce a phenotypic transformation of cancer cells from malignant to benign. This process is currently known as "tumor reversion". However, the concept of reversibility hardly fits the current cancer models, according to which gene mutations are considered the primary cause of cancer. Indeed, if gene mutations are causative carcinogenic factors, and if gene mutations are irreversible, how long should cancer be considered as an irreversible process? In fact, there is some evidence that intrinsic plasticity of cancerous cells may be therapeutically exploited to promote a phenotypic reprogramming, both in vitro and in vivo. Not only are studies on tumor reversion highlighting a new, exciting research approach, but they are also pushing science to look for new epistemological tools capable of better modeling cancer.
Identifiants
pubmed: 37238604
pii: biom13050733
doi: 10.3390/biom13050733
pmc: PMC10216038
pii:
doi:
Substances chimiques
Carcinogens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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