Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities.


Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
14 05 2023
Historique:
received: 09 03 2023
revised: 05 05 2023
accepted: 10 05 2023
medline: 29 5 2023
pubmed: 27 5 2023
entrez: 27 5 2023
Statut: epublish

Résumé

The 4-aminoquinoline drugs, such as chloroquine (CQ), amodiaquine or piperaquine, are still commonly used for malaria treatment, either alone (CQ) or in combination with artemisinin derivatives. We previously described the excellent in vitro activity of a novel pyrrolizidinylmethyl derivative of 4-amino-7-chloroquinoline, named

Identifiants

pubmed: 37238706
pii: biom13050836
doi: 10.3390/biom13050836
pmc: PMC10216263
pii:
doi:

Substances chimiques

Antimalarials 0
Chloroquine 886U3H6UFF
Quinolines 0
Artemisinins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

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Auteurs

Nicoletta Basilico (N)

Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche (DiSBIOC), Università Degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy.

Silvia Parapini (S)

Dipartimento di Scienze Biomediche per la Salute, Università Degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy.

Sarah D'Alessandro (S)

Dipartimento di Scienze Farmacologiche e Biomolecolari (DISFEB), Università Degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy.

Paola Misiano (P)

Dipartimento di Scienze Farmacologiche e Biomolecolari (DISFEB), Università Degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy.

Sergio Romeo (S)

Dipartimento di Scienze Farmaceutiche (DISFARM), Università Degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.

Giulio Dondio (G)

Aphad Srl, Via della Resistenza 65, Buccinasco, 20090 Milan, Italy.

Vanessa Yardley (V)

Department of Immunology Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, London WC1E 7HT, UK.

Livia Vivas (L)

Department of Immunology Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, London WC1E 7HT, UK.

Shereen Nasser (S)

Department of Immunology Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, London WC1E 7HT, UK.

Laurent Rénia (L)

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
A*STAR Infectious Diseases Labs, Agency for Science, Technology, and Research, Singapore 138648, Singapore.

Bruce M Russell (BM)

Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand.

Rossarin Suwanarusk (R)

Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand.

François Nosten (F)

Shoklo Malaria Research Unit, Mahidol-Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot 63110, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

Anna Sparatore (A)

Dipartimento di Scienze Farmaceutiche (DISFARM), Università Degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.

Donatella Taramelli (D)

Dipartimento di Scienze Farmacologiche e Biomolecolari (DISFEB), Università Degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy.

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Classifications MeSH