Nicotine Administration Augments Abdominal Aortic Aneurysm Progression in Rats.
alpha7 nicotinic acetylcholine receptor
animal model
aortic aneurysm
inflammation
nicotine
therapeutic strategy
vascular remodeling
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
10 May 2023
10 May 2023
Historique:
received:
01
03
2023
revised:
30
04
2023
accepted:
05
05
2023
medline:
27
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Inflammation and elastin degradation are key hallmarks in the pathogenesis of abdominal aortic aneurysms (AAAs). It has been acknowledged that activation of alpha7 nicotinic acetylcholine receptors (α7nAChRs) attenuates inflammation, termed the cholinergic anti-inflammatory pathway (CAP). Thus, we hypothesize that low-dose nicotine impairs the progression of elastase-induced AAAs in rats by exerting anti-inflammatory and anti-oxidative stress properties. Male Sprague-Dawley rats underwent surgical AAA induction with intraluminal elastase infusion. We compared vehicle rats with rats treated with nicotine (1.25 mg/kg/day), and aneurysm progression was monitored by weekly ultrasound images for 28 days. Nicotine treatment significantly promoted AAA progression (
Identifiants
pubmed: 37239088
pii: biomedicines11051417
doi: 10.3390/biomedicines11051417
pmc: PMC10216524
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : The Region of Southern Denmark
ID : 19/25225
Organisme : A .P. Møllers Fond
ID : 20-L-0105
Références
J Cell Physiol. 2019 Sep;234(9):14507-14518
pubmed: 30585623
Nat Rev Dis Primers. 2018 Oct 18;4(1):34
pubmed: 30337540
J Clin Med. 2019 Apr 11;8(4):
pubmed: 30979062
J Neurosci. 2018 Nov 28;38(48):10271-10285
pubmed: 30301754
Cochrane Database Syst Rev. 2020 Jul 1;7:CD001835
pubmed: 32609382
J Am Heart Assoc. 2015 Oct 08;4(10):e002255
pubmed: 26450120
Br J Pharmacol. 2018 Apr;175(8):1279-1292
pubmed: 28430357
Circulation. 2012 Sep 11;126(11 Suppl 1):S38-45
pubmed: 22965992
Scand J Immunol. 2007 Nov;66(5):538-45
pubmed: 17953529
Neuropharmacology. 2010 Jun;58(7):1054-66
pubmed: 20114055
Clin Exp Immunol. 2006 Oct;146(1):116-23
pubmed: 16968406
Inflammation. 2021 Jun;44(3):821-834
pubmed: 33405021
J Immunol. 2016 Jun 1;196(11):4536-43
pubmed: 27183603
Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2116-22
pubmed: 15331435
Trends Cardiovasc Med. 2016 Aug;26(6):515-23
pubmed: 27079891
J Neuroimmune Pharmacol. 2015 Sep;10(3):468-76
pubmed: 25870122
J Neuroimmunol. 2010 Oct 8;227(1-2):44-51
pubmed: 20615555
Tob Control. 2011 May;20 Suppl 1:i17-20
pubmed: 21504918
J Vasc Surg. 2019 Dec;70(6):2021-2031.e1
pubmed: 30929966
Innovation (Camb). 2021 Jul 01;2(3):100141
pubmed: 34557778
Atherosclerosis. 2014 Dec;237(2):464-70
pubmed: 25463075
Biomedicines. 2022 Feb 02;10(2):
pubmed: 35203568
Front Immunol. 2021 Apr 28;12:642071
pubmed: 33995360
PLoS One. 2017 Dec 13;12(12):e0188439
pubmed: 29236702
Abdom Radiol (NY). 2018 May;43(5):1032-1043
pubmed: 29313113
Cell Res. 2013 Nov;23(11):1270-83
pubmed: 23979021
Atherosclerosis. 2019 Aug;287:122-133
pubmed: 31260875
J Immunol. 2019 Jul 15;203(2):485-492
pubmed: 31152077
Circulation. 2017 Aug 29;136(9):787-797
pubmed: 28720724
Nat Rev Cardiol. 2019 Apr;16(4):225-242
pubmed: 30443031
Glob Heart. 2021 May 04;16(1):35
pubmed: 34040948
Mediators Inflamm. 2012;2012:103120
pubmed: 22529515
Food Chem Toxicol. 2021 May;151:112154
pubmed: 33774093
Cell Mol Life Sci. 2011 Mar;68(6):931-49
pubmed: 20953658
Br J Pharmacol. 2007 Aug;151(7):915-29
pubmed: 17502850
Atherosclerosis. 2016 Jan;244:113-20
pubmed: 26613536
Psychopharmacology (Berl). 2007 Feb;190(3):269-319
pubmed: 16896961
Eur J Vasc Endovasc Surg. 2019 Jan;57(1):8-93
pubmed: 30528142
Front Immunol. 2021 Feb 08;11:595342
pubmed: 33633726
J Basic Clin Pharm. 2016 Mar;7(2):27-31
pubmed: 27057123
Acta Cardiol Sin. 2014 Mar;30(2):108-13
pubmed: 27122776
Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):401-410
pubmed: 28062500
Br J Pharmacol. 2010 Aug;160(7):1577-9
pubmed: 20649561
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):817-28
pubmed: 25614278
Eur J Vasc Endovasc Surg. 2016 Oct;52(4):487-499
pubmed: 27543385
Expert Rev Cardiovasc Ther. 2015;13(9):975-87
pubmed: 26308600
Vascular. 2012 Oct;20(5):278-83
pubmed: 23091264
Front Physiol. 2018 Oct 31;9:1459
pubmed: 30429794
J Pharmacol Exp Ther. 2012 Jun;341(3):756-63
pubmed: 22427701
Atherosclerosis. 2020 Oct;311:73-83
pubmed: 32949946
Front Immunol. 2021 Feb 03;11:609161
pubmed: 33613530
J Am Heart Assoc. 2015 Aug 19;4(8):e001926
pubmed: 26289347
Angiogenesis. 2013 Oct;16(4):795-807
pubmed: 23709172
Eur J Pharmacol. 2013 May 5;707(1-3):61-70
pubmed: 23535606
Arthritis Rheum. 2009 Jan;60(1):114-22
pubmed: 19116908
J Am Coll Cardiol. 2021 Jul 20;78(3):201-211
pubmed: 34266574
Eur J Vasc Endovasc Surg. 2017 Jan;53(1):123-131
pubmed: 27890524
N Engl J Med. 2014 Nov 27;371(22):2101-8
pubmed: 25427112
Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552
pubmed: 34723319
Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H652-H670
pubmed: 32083977
Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):53-65
pubmed: 27834689
Sci Rep. 2021 Jun 18;11(1):12903
pubmed: 34145342
Front Physiol. 2020 Dec 23;11:621769
pubmed: 33424644
Clin Sci (Lond). 2016 Mar;130(5):301-15
pubmed: 26814202
Vascul Pharmacol. 2014 May-Jun;61(2-3):49-55
pubmed: 24685818
Regul Pept. 2005 May 15;128(1):43-50
pubmed: 15721486
Mol Med. 2008 Sep-Oct;14(9-10):567-74
pubmed: 18584048
Acta Pharmacol Sin. 2022 Oct;43(10):2585-2595
pubmed: 35217818
Lab Anim. 2012 Oct;46(4):349-51
pubmed: 22969145
Kidney Int. 2008 Jul;74(1):62-9
pubmed: 18401335
J Vasc Surg. 2015 Jun;61(6):1565-74.e1-4
pubmed: 24582702