Mesenchymal Stem Cell in Pancreatic Islet Transplantation.
exosomes
immunomodulation
mesenchymal stem cells
nanotubes
pancreatic islets
transplantation
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
11 May 2023
11 May 2023
Historique:
received:
04
04
2023
revised:
02
05
2023
accepted:
08
05
2023
medline:
27
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Pancreatic islet transplantation is a therapeutic option for achieving physiologic regulation of plasma glucose in Type 1 diabetic patients. At the same time, mesenchymal stem cells (MSCs) have demonstrated their potential in controlling graft rejection, the most fearsome complication in organ/tissue transplantation. MSCs can interact with innate and adaptive immune system cells either through direct cell-cell contact or through their secretome including exosomes. In this review, we discuss current findings regarding the graft microenvironment of pancreatic islet recipient patients and the crucial role of MSCs operation as cell managers able to control the immune system to prevent rejection and promote endogenous repair. We also discuss how challenging stressors, such as oxidative stress and impaired vasculogenesis, may jeopardize graft outcomes. In order to face these adverse conditions, we consider either hypoxia-exposure preconditioning of MSCs or human stem cells with angiogenic potential in organoids to overcome islets' lack of vasculature. Along with the shepherding of carbon nanotubes-loaded MSCs to the transplantation site by a magnetic field, these studies look forward to exploiting MSCs stemness and their immunomodulatory properties in pancreatic islet transplantation.
Identifiants
pubmed: 37239097
pii: biomedicines11051426
doi: 10.3390/biomedicines11051426
pmc: PMC10216083
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Nanomedicine (Lond). 2011 Jan;6(1):43-54
pubmed: 21182417
Front Cell Dev Biol. 2016 Oct 17;4:114
pubmed: 27800477
Curr Med Chem. 2012;19(1):90-7
pubmed: 22300081
J Mol Cell Cardiol. 2007 Jun;42(6):1036-44
pubmed: 17498737
Stem Cell Res Ther. 2016 Feb 06;7:24
pubmed: 26852014
Cytotherapy. 2013 Feb;15(2):154-62
pubmed: 23321327
PLoS One. 2013 May 28;8(5):e63638
pubmed: 23723991
Cell Transplant. 2018 Nov;27(11):1657-1683
pubmed: 30311501
Stem Cell Res Ther. 2021 Oct 30;12(1):561
pubmed: 34717769
Curr Pharm Des. 2019;25(42):4510-4522
pubmed: 31724509
Mol Cell Endocrinol. 2016 Dec 5;437:1-10
pubmed: 27496642
Cell Prolif. 2018 Apr;51(2):e12434
pubmed: 29341316
Mol Med Rep. 2012 Nov;6(5):1183-9
pubmed: 22923041
Stem Cells Dev. 2015 Jul 15;24(14):1635-47
pubmed: 25867197
World J Gastroenterol. 2003 Oct;9(10):2274-7
pubmed: 14562392
Stem Cell Res Ther. 2021 Mar 18;12(1):192
pubmed: 33736695
Cancers (Basel). 2022 May 24;14(11):
pubmed: 35681572
Diabetologia. 2016 Oct;59(10):2125-33
pubmed: 27460666
Trends Pharmacol Sci. 2020 Sep;41(9):653-664
pubmed: 32709406
Curr Pharm Des. 2011;17(29):3229-42
pubmed: 21864271
J Embryol Exp Morphol. 1966 Dec;16(3):381-90
pubmed: 5336210
Exp Biol Med (Maywood). 2013 Jun;238(6):687-95
pubmed: 23918880
Stem Cells Transl Med. 2016 Nov;5(11):1485-1495
pubmed: 27412884
J Cell Mol Med. 2018 Mar;22(3):1428-1442
pubmed: 29392844
Cell Transplant. 2012;21(5):889-900
pubmed: 22182941
Nat Med. 1998 May;4(5):594-600
pubmed: 9585234
Front Cell Dev Biol. 2021 Jul 05;9:669381
pubmed: 34291045
Transplant Rev (Orlando). 2013 Jan;27(1):21-9
pubmed: 23290684
Gastroenterology. 2011 Mar;140(3):998-1008
pubmed: 21130088
Leukemia. 2014 Apr;28(4):970-3
pubmed: 24445866
Vet World. 2021 Aug;14(8):2109-2117
pubmed: 34566328
Stem Cell Res Ther. 2018 Dec 29;9(1):355
pubmed: 30594258
iScience. 2019 May 31;15:421-438
pubmed: 31121468
J Biol Regul Homeost Agents. 2020 Sep-Oct;34(5 Suppl. 1):33-38. IORS Special Issue on Orthopedics
pubmed: 33739002
Circ Res. 2011 Sep 16;109(7):724-8
pubmed: 21835908
Lancet Diabetes Endocrinol. 2018 Jul;6(7):527-537
pubmed: 29776895
Cell Commun Signal. 2011 May 14;9:12
pubmed: 21569606
Cell Transplant. 2013;22(2):253-66
pubmed: 22710383
Ann Biomed Eng. 2022 Oct;50(10):1177-1186
pubmed: 35804253
PLoS One. 2013;8(2):e56924
pubmed: 23437272
Acta Diabetol. 2014 Oct;51(5):833-43
pubmed: 25034311
Cell Stem Cell. 2013 Oct 3;13(4):392-402
pubmed: 24094322
J Mol Endocrinol. 2017 Nov;59(4):R155-R165
pubmed: 28835418
Lancet. 2004 May 1;363(9419):1439-41
pubmed: 15121408
Cytotherapy. 2013 Sep;15(9):1054-61
pubmed: 23602578
Ann N Y Acad Sci. 2009 Sep;1176:101-17
pubmed: 19796238
Stem Cells Dev. 2016 May 1;25(9):661-73
pubmed: 26975798
Stem Cells Transl Med. 2014 Dec;3(12):1484-94
pubmed: 25313200
Cell Transplant. 2015;24(8):1555-70
pubmed: 25198179
Stem Cells Int. 2020 Mar 9;2020:4356359
pubmed: 32215017
Cytokine Growth Factor Rev. 2019 Jun;47:32-42
pubmed: 31129018
Ann N Y Acad Sci. 2012 Aug;1266:107-17
pubmed: 22901262
Diabetes. 2005 Jul;54(7):2060-9
pubmed: 15983207
Cell Death Dis. 2018 Mar 7;9(3):386
pubmed: 29515165
Nat Biotechnol. 2014 Mar;32(3):252-60
pubmed: 24561556
Stem Cell Rev Rep. 2023 Apr 14;:
pubmed: 37058201
Sci Rep. 2019 Aug 12;9(1):11701
pubmed: 31406275
Ann N Y Acad Sci. 2008 Dec;1150:213-6
pubmed: 19120298
J Vis Exp. 2016 Jul 15;(113):
pubmed: 27500428
Front Cell Dev Biol. 2022 Nov 02;10:1005926
pubmed: 36407112
Stem Cells Transl Med. 2015 May;4(5):513-22
pubmed: 25824139
J Clin Pathol. 2004 Oct;57(10):1009-14
pubmed: 15452150
Cell Mol Life Sci. 2020 Jul;77(14):2771-2794
pubmed: 31965214
J Mol Med (Berl). 2014 Apr;92(4):387-97
pubmed: 24337504
Stem Cells. 2019 Jun;37(6):813-827
pubmed: 30835892
Stem Cells Dev. 2017 May 1;26(9):617-631
pubmed: 28186467
Stem Cells Int. 2021 Jul 28;2021:6663467
pubmed: 34367293
J Clin Med. 2020 Feb 06;9(2):
pubmed: 32041213
N Engl J Med. 2011 Feb 17;364(7):656-65
pubmed: 21323543
Stem Cells. 2008 May;26(5):1275-87
pubmed: 18292209
Int J Immunopathol Pharmacol. 2012 Jan-Mar;25(1):75-85
pubmed: 22507320
Front Cell Dev Biol. 2020 Dec 08;8:596452
pubmed: 33364234
N Engl J Med. 2000 Jul 27;343(4):230-8
pubmed: 10911004
J Control Release. 2016 Sep 28;238:166-175
pubmed: 27475298
Stem Cells. 2006 Feb;24(2):386-98
pubmed: 16123384
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Cell Physiol Biochem. 2015;37(6):2415-24
pubmed: 26646808
Cell Transplant. 2012;21(6):1305-20
pubmed: 22455973
Cells. 2022 Aug 30;11(17):
pubmed: 36078106
World J Gastroenterol. 2012 May 14;18(18):2270-9
pubmed: 22611322
Int J Nanomedicine. 2019 Jul 24;14:5679-5690
pubmed: 31413568
Biomark Res. 2019 Mar 18;7:6
pubmed: 30923617
Stem Cell Res Ther. 2017 May 2;8(1):106
pubmed: 28464921
PLoS One. 2010 Apr 26;5(4):e10088
pubmed: 20436665
Diabetes Technol Ther. 2010 Jun;12(6):435-46
pubmed: 20470228
Biomed Pharmacother. 2021 Oct;142:112042
pubmed: 34403963
Immunol Lett. 2020 Mar;219:34-45
pubmed: 31917251
PLoS One. 2018 May 3;13(5):e0196570
pubmed: 29723228
Oxid Med Cell Longev. 2017;2017:3839756
pubmed: 28386307
Cell Transplant. 2016;25(3):531-8
pubmed: 26177261
J Anat. 2017 Mar;230(3):381-388
pubmed: 27861845
Cell Death Discov. 2015 Aug 24;1:15007
pubmed: 27551443
Int J Clin Exp Pathol. 2015 May 01;8(5):4457-68
pubmed: 26191136
Front Endocrinol (Lausanne). 2022 Feb 09;13:822191
pubmed: 35222280
Am J Transplant. 2009 Dec;9(12):2816-24
pubmed: 19845588
Am J Transplant. 2021 Apr;21(4):1493-1502
pubmed: 32986297