Neuroprotective Effect of a Nutritional Supplement Containing Spearmint Extract, Forskolin, Homotaurine and Group B Vitamins in a Mouse Model of Transient Ocular Hypertension.
apoptosis
dietary supplement
glaucoma
natural products
neuroprotection
nutrients
retinal ganglion cells
retinal ischemia
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
18 May 2023
18 May 2023
Historique:
received:
10
04
2023
revised:
09
05
2023
accepted:
16
05
2023
medline:
27
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Glaucoma is one of the most common sight-threatening eye disorders and one of the main causes of irreversible blindness worldwide. The current therapies focusing on reducing intraocular pressure (IOP) are often insufficient to prevent the progression of the disease, so the therapeutic management of glaucoma remains a challenge. The aim of this study was to evaluate the neuroprotective, IOP-lowering independent effects of a nutritional supplement containing forskolin, homotaurine, spearmint extract and vitamins of the B group in a model of acute glaucoma developed in mice. Glaucoma was induced in adult wild-type C57BL/6J mice by transient elevation of IOP. The dietary supplement, branded as Gangliomix
Identifiants
pubmed: 37239149
pii: biomedicines11051478
doi: 10.3390/biomedicines11051478
pmc: PMC10216629
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fidia Farmaceutici (Italy)
ID : Financial support
Références
N Engl J Med. 2009 Mar 12;360(11):1113-24
pubmed: 19279343
J Pers Med. 2022 Nov 10;12(11):
pubmed: 36579616
J Comp Neurol. 2019 Jan 1;527(1):225-235
pubmed: 28078709
Neuroscience. 2003;116(3):733-42
pubmed: 12573715
FASEB J. 2008 Mar;22(3):659-61
pubmed: 17942826
Neural Regen Res. 2019 Mar;14(3):391-394
pubmed: 30539803
Oxid Med Cell Longev. 2020 May 9;2020:2692794
pubmed: 32454935
Neuron. 1995 Oct;15(4):805-19
pubmed: 7576630
Yan Ke Xue Bao. 1995 Sep;11(3):173-6
pubmed: 8758848
Methods. 2015 Mar;75:79-86
pubmed: 25644445
Cureus. 2020 Nov 24;12(11):e11686
pubmed: 33391921
Lancet. 1983 Apr 30;1(8331):958-60
pubmed: 6132271
Cell Death Discov. 2017 Jul 03;3:17032
pubmed: 29675270
Curr Opin Pharmacol. 2022 Feb;62:137-144
pubmed: 34995895
Glia. 2013 Aug;61(8):1218-35
pubmed: 23650091
Curr Opin Pharmacol. 2013 Feb;13(1):128-33
pubmed: 22981808
Cell J. 2011 Summer;13(2):65-72
pubmed: 23507938
Eye (Lond). 2020 Sep;34(9):1546-1553
pubmed: 32152519
Aging Clin Exp Res. 2012 Dec;24(6):580-7
pubmed: 22961121
Exp Eye Res. 1984 Jul;39(1):47-50
pubmed: 6541150
Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2509-2514
pubmed: 31185090
Mitochondrion. 2017 Jul;35:44-53
pubmed: 28499981
Invest Ophthalmol Vis Sci. 2011 Jan 25;52(1):504-18
pubmed: 20847120
Clin Exp Ophthalmol. 2012 May-Jun;40(4):341-9
pubmed: 22356435
J Ophthalmol. 2019 Jan 15;2019:1803619
pubmed: 30766729
Saudi J Ophthalmol. 2015 Jul-Sep;29(3):197-200
pubmed: 26155078
Nature. 1994 Sep 22;371(6495):346-7
pubmed: 8090205
Cell Death Dis. 2011 Apr 14;2:e144
pubmed: 21490676
Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2697-705
pubmed: 10509668
J Clin Invest. 2011 Apr;121(4):1429-44
pubmed: 21383504
Invest Ophthalmol Vis Sci. 1996 Sep;37(10):2002-14
pubmed: 8814140
Int Rev Neurobiol. 2009;85:407-23
pubmed: 19607984
Graefes Arch Clin Exp Ophthalmol. 2015 Nov;253(11):1841-50
pubmed: 26340868
Prog Brain Res. 2020;257:141-154
pubmed: 32988469
J Exp Pharmacol. 2020 Nov 20;12:539-548
pubmed: 33244278
Int J Mol Sci. 2019 Feb 23;20(4):
pubmed: 30813414
Surv Ophthalmol. 2008 Mar-Apr;53(2):150-63
pubmed: 18348880
Cold Spring Harb Perspect Med. 2014 Jun 02;4(6):
pubmed: 24890835
J Int Soc Sports Nutr. 2018 Dec 12;15(1):58
pubmed: 30541572
Mol Vis. 2015 Jun 29;21:718-29
pubmed: 26167113
Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3860-8
pubmed: 19264888
Prog Brain Res. 2015;220:87-105
pubmed: 26497786
Biomed Pharmacother. 2022 May;149:112911
pubmed: 36068774
Redox Biol. 2021 Jul;43:101988
pubmed: 33932867
Front Neurol. 2020 Jul 07;11:614
pubmed: 32733362
J Ocul Pharmacol Ther. 2014 Jun;30(5):419-28
pubmed: 24660785
Nutrients. 2020 Apr 23;12(4):
pubmed: 32340314
Cold Spring Harb Perspect Med. 2014 Jul 03;4(8):
pubmed: 24993677
Prog Retin Eye Res. 2012 Mar;31(2):152-81
pubmed: 22155051
Eur J Pharmacol. 2013 Mar 15;704(1-3):70-7
pubmed: 23461850
Science. 2017 Feb 17;355(6326):756-760
pubmed: 28209901
JAMA. 2014 May 14;311(18):1901-11
pubmed: 24825645
J Pharmacol Exp Ther. 2002 Mar;300(3):717-23
pubmed: 11861773
Free Radic Res. 2006 Feb;40(2):223-31
pubmed: 16390832
Br J Pharmacol. 2009 Jul;157(6):1072-84
pubmed: 19466982
Clin Exp Ophthalmol. 2020 Sep;48(7):903-914
pubmed: 32721104
J Ophthalmic Vis Res. 2016 Apr-Jun;11(2):204-8
pubmed: 27413503
Basic Clin Pharmacol Toxicol. 2015 May;116(5):398-413
pubmed: 25287116
Biomedicines. 2021 Sep 07;9(9):
pubmed: 34572363
Int J Mol Sci. 2020 Mar 25;21(7):
pubmed: 32218163
J Photochem Photobiol B. 2019 Jan;190:172-178
pubmed: 30268421
ISRN Ophthalmol. 2013 Jul 16;2013:261386
pubmed: 24558600
Prog Brain Res. 2015;221:49-65
pubmed: 26518072
Cell Death Dis. 2018 Sep 24;9(10):981
pubmed: 30250019
Exp Eye Res. 2015 Jan;130:29-37
pubmed: 25450059
Neuropharmacology. 2014 Aug;83:107-17
pubmed: 24769446
Oxid Med Cell Longev. 2017;2017:2825703
pubmed: 29163753
Curr Eye Res. 2000 Jul;21(1):571-80
pubmed: 11035539
Trends Neurosci. 2000 Jan;23(1):20-6
pubmed: 10631785
Exp Eye Res. 1984 Dec;39(6):745-9
pubmed: 6542866
Nutrients. 2019 Dec 03;11(12):
pubmed: 31816880
Surv Ophthalmol. 2019 Mar - Apr;64(2):195-216
pubmed: 30296451
Oxid Med Cell Longev. 2019 Feb 12;2019:9783429
pubmed: 30891116
Nutrients. 2020 Oct 16;12(10):
pubmed: 33081127
FEBS Lett. 2013 Jun 27;587(13):2008-17
pubmed: 23684651